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    SYSTEM FOR COMMUNICATING INFORMATION FROM AN ARRAY OF SENSORS
    2.
    发明公开
    SYSTEM FOR COMMUNICATING INFORMATION FROM AN ARRAY OF SENSORS 审中-公开
    系统ZUR KOMMUNIKATION VON INFORMATIONEN AUS EINER SENSORREIHE

    公开(公告)号：EP2668645A4

    公开(公告)日：2017-01-04

    申请号：EP11857055

    申请日：2011-12-12

    申请人： GENIA TECH INC

    发明人： CHEN ROGER

    IPC分类号： G01N33/487

    CPC分类号： G01N27/3278 ,  C12Q1/6874 ,  G01N27/44791 ,  G01N33/48721

    摘要： A system for communicating information from an array of sensors is disclosed. The system comprises a sensor array that includes a plurality of sensors, wherein each sensor senses a physical property of a material that is in communication with the sensor. The system further comprises signal processing circuitry associated with each sensor that integrates the output of the sensor over time and compares the integrated output to a threshold. The system further comprises a communication network coupled to the signal processing circuitry that outputs information indicating that the integrated output corresponding to a given sensor has reached the threshold.

    摘要翻译： 公开了一种用于检测分子复合物的电性能的系统。 该系统包括电耦合到分子复合物的电极，其输出受分子复合物的电特性影响的电信号，其中分子复合物的电特性对电信号的影响的特征在于期望的带宽。 该系统还包括积分放大器电路，其被配置为：从电极接收电信号。 积分放大器电路还被配置为在预定带宽内随时间选择性地放大和积分电信号的一部分，其中至少部分地基于预期带宽来选择预定带宽。

    NANOPORE-BASED SEQUENCING CHIPS USING STACKED WAFER TECHNOLOGY
    4.
    发明公开
    NANOPORE-BASED SEQUENCING CHIPS USING STACKED WAFER TECHNOLOGY 审中-公开
    NANOPORENBASIERTE CHIPSEQUENZIERUNG MIT GESTAPELTER WAFERTECHNOLOGIE

    公开(公告)号：EP3122891A4

    公开(公告)日：2017-09-27

    申请号：EP15769702

    申请日：2015-03-11

    申请人： GENIA TECH INC

    发明人： TIAN HUI

    IPC分类号： C12Q1/00 ,  C12M1/34 ,  C12Q1/68 ,  G01N33/487

    CPC分类号： G01N33/48721

    摘要： A nanopore based sequencing chip is disclosed. The sequencing chip comprises a first portion made from a first wafer. The first portion includes an array of nanopore cells. The first portion further includes a measurement circuit connected to one or more nanopore cells, the measurement circuit producing an output measurement signal. The first portion further includes one or more vias transmitting the output measurement signal. The sequencing chip further includes a second portion made from a second wafer, the second portion comprising one or more corresponding vias receiving the output measurement signal.

    摘要翻译： 公开了一种基于纳米孔的测序芯片。 测序芯片包括由第一晶片制成的第一部分。 第一部分包括纳米孔单元阵列。 第一部分还包括连接到一个或多个纳米孔单元的测量电路，测量电路产生输出测量信号。 第一部分还包括传输输出测量信号的一个或多个通孔。 测序芯片还包括由第二晶片制成的第二部分，第二部分包括接收输出测量信号的一个或多个对应的通孔。

    NON-FARADAIC, CAPACITIVELY COUPLED MEASUREMENT IN A NANOPORE CELL ARRAY
    5.
    发明公开
    NON-FARADAIC, CAPACITIVELY COUPLED MEASUREMENT IN A NANOPORE CELL ARRAY 审中-公开
    KAPAZITIV GEKOPPELTE NICHT-FARADAY-MESSUNG IN EINER NANOPOREN-ZELLENMATRIX

    公开(公告)号：EP3058102A4

    公开(公告)日：2017-08-02

    申请号：EP14853691

    申请日：2014-09-11

    申请人： GENIA TECH INC

    发明人： CHEN ROGER J A

    IPC分类号： C12Q1/68 ,  C40B20/00 ,  C40B20/04 ,  G01N33/487

    CPC分类号： G01N27/44791 ,  G01N27/3278 ,  G01N27/4473 ,  G01N27/44743 ,  G01N33/48721

    摘要： A method of identifying a molecule is disclosed. A molecule is drawn to a nanopore by applying a first voltage signal to a pair of electrodes during a first period, wherein the first voltage signal causes a first ionic current through the nanopore that is indicative of a property of a portion of the molecule proximate to the nanopore. The molecule is released from the nanopore by applying a second voltage signal to the pair of electrodes during a second period, wherein the second voltage signal causes a second ionic current through the nanopore. The first period and the second period are determined based at least in part on a net ionic current through the nanopore comprising the first ionic current and the second ionic current.

    摘要翻译： 公开了一种鉴定分子的方法。 通过在第一时段期间将第一电压信号施加到一对电极而将分子吸引到纳米孔，其中第一电压信号引起通过纳米孔的第一离子电流，所述第一离子电流指示分子的一部分接近 纳米孔。 通过在第二时段期间向该对电极施加第二电压信号而从纳米孔释放分子，其中第二电压信号引起通过纳米孔的第二离子电流。 第一时段和第二时段至少部分地基于通过纳米孔的净离子电流来确定，所述净离子电流包括第一离子电流和第二离子电流。

    TEMPERATURE REGULATION OF MEASUREMENT ARRAYS
    6.
    发明公开
    TEMPERATURE REGULATION OF MEASUREMENT ARRAYS 审中-公开
    TEMPERATUREGELUNG VON MESSARRAYS

    公开(公告)号：EP2668258A4

    公开(公告)日：2017-07-26

    申请号：EP12739380

    申请日：2012-01-10

    申请人： GENIA TECH INC

    发明人： CHEN ROGER

    IPC分类号： G05D23/19 ,  B01J19/00 ,  G05D23/20

    CPC分类号： B01J19/0046 ,  B01J2219/00495 ,  B01J2219/00698 ,  G05D23/1919 ,  G05D23/2034 ,  G05D23/2037

    摘要： A system for regulating a temperature of a measurement array is disclosed. The system includes a measurement array including a plurality of sensors, wherein the plurality of sensors are integrated onto an integrated circuit die. The system includes a thermal sensor integrated onto the integrated circuit die, wherein the thermal sensor senses a temperature associated with the plurality of sensors. The system further includes a heat pump coupled to the integrated circuit die, wherein the heat pump is controlled by a feedback control circuit including the thermal sensor.

    摘要翻译： 公开了一种用于调节测量阵列的温度的系统。 该系统包括包含多个传感器的测量阵列，其中多个传感器被集成到集成电路管芯上。 该系统包括集成到集成电路管芯上的热传感器，其中热传感器感测与多个传感器相关联的温度。 该系统还包括耦合到集成电路管芯的热泵，其中热泵由包括热传感器的反馈控制电路控制。

    HIGH SPEED MOLECULAR SENSING WITH NANOPORES
    8.
    发明公开
    HIGH SPEED MOLECULAR SENSING WITH NANOPORES 审中-公开
    SCHNELLE MOLEKULARE ERFASSUNG MIT NANOPOREN

    公开(公告)号：EP3060918A4

    公开(公告)日：2017-06-07

    申请号：EP14855081

    申请日：2014-10-23

    申请人： GENIA TECH INC

    发明人： DAVIS RANDALL W

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  G01N33/566

    CPC分类号： C12Q1/6869 ,  C12Q1/6816 ,  C12Q2561/125 ,  C12Q2563/143 ,  C12Q2565/631 ,  C12Q2545/114

    摘要： Described herein are methods and devices for capturing and determining the identity of molecules using nanopores. The molecules can be counted, sorted and/or binned rapidly in a parallel manner using a large number of nanopores (e.g., 132,000 nanopores reading 180 million molecules in 1 hour). This fast capture and reading of a molecule can be used to capture probe molecules or other molecules that have been generated to represent an original, hard to detect molecule or portions of an original molecule. Precise counting of sample molecules or surrogates for sample molecules can occur. The methods and devices described herein can, among other things, replace flow cytometers and other counting instruments (e.g., while providing increased precision and throughput relative to a flow cytometer). In some cases, the devices and methods capture and hold particular molecules or surrogates of molecules in the nanopores and then eject them into clean solution to perform a capture, sorting, and binning function similar to flow cytometers.

    摘要翻译： 本文描述了用于使用纳米孔捕获和确定分子的身份的方法和装置。 可以使用大量纳米孔（例如，在1小时内读取1亿8千万个分子的132,000个纳米孔）以平行方式快速对分子进行计数，分选和/或装仓。 这种分子的快速捕获和读取可用于捕获已经产生的探针分子或其他分子，以代表原始的，难以检测的分子或原始分子的部分。 可能会发生样品分子或样品分子替代物的精确计数。 本文所述的方法和装置尤其可替代流式细胞仪和其他计数仪器（例如，相对于流式细胞仪提供增加的精确度和通量）。 在某些情况下，这些装置和方法捕获和保持纳米孔中分子的特定分子或替代物，然后将它们喷射到清洁的溶液中以执行类似于流式细胞仪的捕获，分选和装仓功能。

    NANOPORE ARRAYS
    10.
    发明公开
    NANOPORE ARRAYS 审中-公开
    多孔纳米阵列

    公开(公告)号：EP2954316A4

    公开(公告)日：2017-01-04

    申请号：EP14748849

    申请日：2014-01-28

    申请人： GENIA TECH INC

    发明人： CHEN ROGER J A ,  FULLAGAR DAVID J

    IPC分类号： G01N33/487

    CPC分类号： G01N33/48721

    摘要： A method of analyzing molecules using a nanopore array including a plurality of cells included on a chip is disclosed. Nanopores are caused to be formed in at least a portion of the plurality of the cells. A first physical measurement of the nanopores is evaluated. It is determined whether to cause the molecules to interact with the nanopores. At least a portion of the nanopores is caused to interact with the molecules. A second physical measurement of the nanopores that indicates a property of the molecules is evaluated. It is determined whether to cause the nanopores to be reformed so that the cells may be reused to interact with additional molecules.