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    METHOD AND APPARATUS FOR TRAINING A COMPUTER-IMPLEMENTED MACHINE-LEARNING MODEL
    1.
    发明公开
    METHOD AND APPARATUS FOR TRAINING A COMPUTER-IMPLEMENTED MACHINE-LEARNING MODEL 审中-公开

    公开(公告)号：EP4372617A1

    公开(公告)日：2024-05-22

    申请号：EP23169568.5

    申请日：2023-04-24

    申请人： Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin

    发明人： Dey, Sharmita ,  Schilling, Arndt

    IPC分类号： G06N3/045 ,  G06N3/0895 ,  A61F2/48 ,  A61F2/68 ,  G06N3/0464 ,  G06N3/096

    CPC分类号： G06N3/045 ,  G06N3/0895 ,  A61F2/48 ,  A61F2/68 ,  G06N3/0464 ,  G06N3/096

    摘要： A method for training a computer-implemented machine-learning model f for controlling a system by control parameter y, wherein said model has been trained to predict a target variable y = f(x) based on an input feature value X, where X is an input value feature value obtained by one or more sensors and used to generate by said model said target variable y as control parameter to thereby control said system,
    wherein said model f has been trained using a first set of training data (yk, xk) corresponding to k =1... N time points to find the trained machine learning model f*
    wherein a backward model g* has been trained based on at least a part of said first set of training data (yk, xk) to predict an input feature value xk+1 based on its preceding input feature value xk and the corresponding target variable yk, said method comprising:
    using said backward model g* to generate second set of training data, which comprises the future input feature values xk+1 predicted by the backward machine learning model g* and the corresponding ground truth variable yk+1,
    training said model f, which has been trained using said first set of training data, using said replay buffer as said second set of training data.

    Pouch-like structure with paracrine activity and method for its preparation
    5.
    发明公开
    Pouch-like structure with paracrine activity and method for its preparation 审中-公开
    Beutelartige Struktur mitParakrinaktivitätund Verfahren zu deren Herstellung

    公开(公告)号：EP2842581A1

    公开(公告)日：2015-03-04

    申请号：EP13182437.7

    申请日：2013-08-30

    申请人： Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin

    发明人： Zimmermann, Wolfram-Hubertus ,  Soong, PohLoong

    IPC分类号： A61L27/38 ,  A61L27/54 ,  A61F2/24 ,  C12N5/071

    CPC分类号： A61K9/009 ,  A61F2/2481 ,  A61K35/28 ,  A61K35/33 ,  A61K35/34 ,  A61K35/44 ,  A61K45/06 ,  A61L31/005 ,  A61L31/16 ,  A61L2300/414 ,  A61L2430/20 ,  C12N5/0697

    摘要： The present invention relates to a pouch-like structure useful for mechanically preventing distension and/or resisting dilation of the heart and for supporting the hearts function by controllable and paracrine support of a failing heart in a mammal. The pouch-like structure is composed at least partly of engineered tissue comprising genetically engineered cells, like, genetically engineered cells other than cardiac myocytes whereby said genetically engineered cells, like genetically engineered cells other than cardiac myocytes, contain a gene encoding a paracrine factor said gene encoding the paracrine factor being under control of an inducible promoter system or an heterologous promoter system. Further, the present invention relates to a method for the preparation and individual of the pouch-like structure for therapeutic, disease modelling, and drug development applications. In addition, the present invention relates to cells other than cardiac myocytes for use in the preparation of the pouch-like structure as described herein.

    摘要翻译： 本发明涉及一种用于机械地防止心脏膨胀和/或抵抗心脏扩张并且用于通过哺乳动物中失败的心脏的可控和旁分泌支持来支持心脏功能的袋状结构。 袋状结构至少部分地由包含基因工程细胞的工程化组织组成，如心肌细胞以外的遗传工程细胞，其中所述基因工程细胞，如心肌细胞以外的基因工程细胞，含有编码旁分泌因子的基因， 编码旁分泌因子的基因在诱导型启动子系统或异源启动子系统的控制下。 此外，本发明涉及用于治疗，疾病建模和药物开发应用的袋状结构的制备和个体的方法。 此外，本发明涉及用于制备如本文所述的袋状结构的心肌细胞以外的细胞。