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公开(公告)号：EP2095128B1
公开(公告)日：2013-10-02
申请号：EP07846655.4
申请日：2007-11-19
申请人： Friedrich-Alexander-Universität Erlangen-Nürnberg , Georg-August-Universität Göttingen - Stiftung Öffentlichen Rechts/Universitätsmedizin
发明人： BIBL, Mirko , MOLLENHAUER, Brit , WILTFANG, Jens , ESSELMANN, Hermann , LEWCZUK, Piotr , KORNHUBER, Johannes
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2871
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公开(公告)号：EP2095128A1
公开(公告)日：2009-09-02
申请号：EP07846655.4
申请日：2007-11-19
申请人： Friedrich-Alexander-Universität Erlangen-Nürnberg , Georg-August-Universität Göttingen - Stiftung Öffentlichen Rechts/Universitätsmedizin
发明人： BIBL, Mirko , MOLLENHAUER, Brit , WILTFANG, Jens , ESSELMANN, Hermann , LEWCZUK, Piotr , KORNHUBER, Johannes
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2871
摘要： In an ex vivo method of differentially diagnosing dementias which include vascular dementias and/or frontotemporal lobe degenerations at least one carboxy-terminally truncated amyloid β peptide selected from the group consisting of Aβ1 -38, Aβ1-37 and Aβ1-39 is used as a biomarker in a body fluid of a patient.
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公开(公告)号：EP2556375A1
公开(公告)日：2013-02-13
申请号：EP11713692.9
申请日：2011-04-07
申请人： Universität Duisburg-Essen , Friedrich-Alexander-Universität Erlangen-Nürnberg , Zentralinstitut Für Seelische Gesundheit , Universitätsklinikum Erlangen
发明人： ESSELMANN, Hermann , GRÖMER, Teja, W. , KORNHUBER, Johannes , LEWCZUK, Piotr , MALER, Juan, Manuel , WILTFANG, Jens
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709
摘要： The invention relates to the use of at least one quantitative ratio (quotient) of two amyloid beta peptidea (A beta; Aß) which are different from one another in a sample of a bodily fluid of a test subject and/or patient in order to determine the probability (risk) of said test subject and/or patient suffering Alzheimer's disease (Morbus Alzheimer, AD) and/or to determine (diagnose) suffering from an early stage of Alzheimer's disease, wherein the amyloid beta peptides are selected from (a) Aß(1-42), (b) Aß(2-40) and (c) Aß(2-42) and wherein the quantitative ratio of (a) / (b) or vice versa and/or of (a) / (c) or vice versa is formed. The invention also relates to a corresponding method and to a kit for use in this connection.
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公开(公告)号：EP1620733A1
公开(公告)日：2006-02-01
申请号：EP04727542.5
申请日：2004-04-15
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , G01N33/6851 , G01N33/6896 , G01N2800/2821
摘要： A method of diagnosis of Alzheimer's disease comprises the step of determining an amount of at least one species in a body fluid or a tissue homogenate sample which has been obtained from a patient. The at least one species is selected from a group of species having molecular masses in a range of 3870 to 3895 Da (Abeta) , 4520 to 4545 Da (Abeta 34) , 4802 to 4836 Da (Abeta 2-46 or Abeta 1-45) , 4837 to 4871 Da (Abeta 3-47) and 7720 to 7790 Da, respectively.
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