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1.发明授权
公开(公告)号：EP3638774B1
公开(公告)日：2024-08-07
申请号：EP18736809.7
申请日：2018-06-14
IPC分类号： C12N5/071
CPC分类号： C12N5/0678 , C12N2501/41520130101 , C12N2501/59920130101 , C12N2506/0220130101 , C12N2506/4520130101 , C12N2500/3820130101 , C12N2501/11920130101 , C12N2501/1620130101 , C12N2501/38520130101 , C12N2500/2520130101 , C12N2501/72720130101 , C12N2501/4120130101 , C12N2501/9120130101 , C12N2500/2220130101
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公开(公告)号：EP4392547A1
公开(公告)日：2024-07-03
申请号：EP22772804.5
申请日：2022-08-26
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3.发明公开
公开(公告)号：EP4380594A1
公开(公告)日：2024-06-12
申请号：EP22761148.0
申请日：2022-08-03
发明人： VON MUTIUS, Erika , RANKL, Bettina , BRACHER, Franz , MÜLLER, Christoph , WALKER, Alesia , HAUCK, Stefanie , MERL-PHAM, Juliane , ADLER, Heiko , YILDIRIM, Ali Önder , SATTLER, Michael , SANTOS DIAS MOURÃO, André , BORGGRÄFE, Jan , O'CONNOR, Patrick David , PLETTENBURG, Oliver
CPC分类号： A61K38/1709 , A61K38/168 , A61K38/385 , A61P37/00 , A61P37/08
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公开(公告)号：EP4351553A1
公开(公告)日：2024-04-17
申请号：EP22735103.8
申请日：2022-06-09
发明人： BURGSTALLER, Gerald , GERCKENS, Michael , PLETTENBURG, Oliver , YILDIRIM, Ali Önder , HUILONG, Ma
IPC分类号： A61K31/167 , A61P17/00 , C07D311/00 , A61K31/42 , A61P35/00 , C07D319/00 , A61P9/00 , C07C233/00 , A61K31/357 , A61P11/00 , C07D213/00 , A61K31/36 , A61P13/12 , C07D249/00 , A61K31/4192
CPC分类号： A61K31/167 , A61K31/42 , A61P35/00 , A61P17/00 , A61P13/12 , A61P9/00 , A61P11/00 , C07C2601/0220170501 , C07C235/38 , C07D213/75 , C07D307/81 , C07D317/60 , C07D311/14 , C07D213/643 , C07D231/20 , A61K31/4192 , A61K31/36 , A61K31/357 , A61P29/00
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公开(公告)号：EP4306169A3
公开(公告)日：2024-04-17
申请号：EP23191359.1
申请日：2016-04-28
CPC分类号： C12N2501/0120130101 , C12N2501/72720130101 , C12N2513/0020130101 , C12N2533/5420130101 , C12N5/0631 , A61P35/00
摘要： The present invention is in the field of stem cell biology, in particular in the field of developmental and regenerative biology. The invention generally relates to a method of generating cells capable of differentiating to a multicellular organoid unit that morphologically and/or functionally resembles the terminal ductal-lobular unit. More precisely, said cells are generated by dissociating mammary epithelial tissue, thereby gaining cells and culturing said cells in presence of a compound which elevates cAMP levels in a collagen gel. Under said culturing conditions said cells form a multicellular organoid unit facilitating to obtain a breast stem cell by isolating a single cell from said multicellular organoid unit. The present invention also relates to enriching said cells and differentiating them to a multicellular organoid that morphologically and/or functionally resembles the terminal ductal-lobular unit and use of said cells or said multicellular organoid in testing a compound. Furthermore, the present invention relates to a composition comprising said breast stem cells or the multicellular organoid.
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公开(公告)号：EP3433269B1
公开(公告)日：2023-09-27
申请号：EP17713250.3
申请日：2017-03-23
IPC分类号： C07K14/705 , C12N15/62
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公开(公告)号：EP3641622B1
公开(公告)日：2022-04-06
申请号：EP18732094.0
申请日：2018-06-22
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公开(公告)号：EP3394290B1
公开(公告)日：2021-09-29
申请号：EP16829076.5
申请日：2016-12-22
发明人： BELKA, Claus , NIYAZI, Karim-Maximilian , UNGER, Kristian , ZITZELSBERGER, Horst , PITEA, Adriana , MITTELBRONN, Michel
IPC分类号： C12Q1/68
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