公开(公告)号：EP4440735A1

公开(公告)日：2024-10-09

申请号：EP22830405.1

申请日：2022-12-01

申请人： Vilnius University

发明人： MAZUTIS, Linas ,  LEONAVICIENE, Greta

IPC分类号： B01J13/04 ,  B01J13/14

CPC分类号： B01J13/046 ,  B01J13/14 ,  A61K2035/1120130101 ,  C12N5/0012 ,  C12N2533/5420130101 ,  C12N2533/4020130101 ,  C12N2513/0020130101 ,  C12N15/88 ,  C12N11/04 ,  C12N11/02 ,  C12N1/04 ,  A61K9/5057 ,  A61K9/5036 ,  A61K47/42 ,  A61K47/32 ,  A61K47/10

公开(公告)号：EP4402247A1

公开(公告)日：2024-07-24

申请号：EP22789868.1

申请日：2022-09-13

申请人： The University Court Of The University Of Glasgow ,  Imperial College Innovations Limited ,  CELLINK Bioprinting AB

发明人： DOBRE, Oana ,  TRUJILLO-MUÑOZ, Sara ,  DALBY, Matthew John ,  SALMERON-SANCHEZ, Manuel ,  OUYANG, Liliang ,  STEVENS, Molly ,  REDWAN, Adel Itedal Namro ,  KUZMENKO, Volodymyr ,  GATENHOLM, Erik ,  MARTÍNEZ, Héctor

IPC分类号： C12N5/00

CPC分类号： C12N5/0068 ,  C12N2533/5420130101 ,  C12N2533/5220130101

公开(公告)号：EP4397751A1

公开(公告)日：2024-07-10

申请号：EP23305007.9

申请日：2023-01-04

申请人： Centre d'Etude des Cellules Souches (CECS)

发明人： The designation of the inventor has not yet been filed

IPC分类号： C12N5/071

CPC分类号： C12N5/0626 ,  C12N2506/0220130101 ,  C12N2506/4520130101 ,  C12N2533/9020130101 ,  C12N2533/5420130101 ,  C12N2501/12520130101 ,  C12N2501/15520130101 ,  C12N2501/36520130101 ,  C12N2501/41520130101 ,  C12N2501/72720130101

摘要： The present invention pertains to in vitro methods for obtaining a population of mature and functional human melanocytes from human pluripotent stem cells (hPSC) and to uses of said population. The method according to the present invention comprises a differentiation step wherein neural crest cells are cultured in presence of a GSK3 inhibitor such as CHIR99021 or WNT3A, BMP4, AA, SCF and EDN3.

公开(公告)号：EP4377442A1

公开(公告)日：2024-06-05

申请号：EP22847766.7

申请日：2022-07-29

申请人： Spiderwort Inc.

发明人： PELLING, Andrew E. ,  CANTO, Anna ,  LOURENCO, Matthew ,  DE SOUSA FARIA TISCHER, Paula Cristina ,  SALAMUN, Joshua ,  HICKEY, Ryan ,  RUSSELL, Colin

IPC分类号： C12N5/00 ,  A23J3/22 ,  A23L5/00 ,  A23L11/00

CPC分类号： A23L11/00 ,  A23L13/00 ,  C12N5/0658 ,  C12N2533/7420130101 ,  C12N2533/5420130101 ,  C12N2537/1020130101 ,  C12N2501/7220130101 ,  C12N2521/0020130101 ,  A23J3/227

公开(公告)号：EP4367218A2

公开(公告)日：2024-05-15

申请号：EP22838158.8

申请日：2022-06-30

申请人： Yeditepe Universitesi

发明人： DOGAN, Aysegul ,  SAGRAC, Derya ,  SENKAL, Selinay ,  HAYAL, Taha Bartu ,  SAHIN, Fikrettin

IPC分类号： C12N5/00 ,  C12N5/0775

CPC分类号： C12N2501/72720130101 ,  C12N2501/11520130101 ,  C12N2533/5420130101 ,  C12N2533/5220130101 ,  C12N2506/0220130101 ,  C12N2533/9020130101 ,  C12N5/0662

公开(公告)号：EP4421158A1

公开(公告)日：2024-08-28

申请号：EP23305244.8

申请日：2023-02-23

申请人： SARTORIUS STEDIM FMT SAS ,  UNIVERSITE CLAUDE BERNARD - LYON 1 ,  Institut National des Sciences Appliquées de Lyon ,  Ecole Superieure de Chimie Physique Electronique de Lyon ,  Centre National de la Recherche Scientifique

发明人： Petiot, Emma ,  Chocarro ,  Courtial, Edwin-Joffrey

IPC分类号： C12M1/12 ,  C12M1/26 ,  C12N5/00 ,  C12N11/04 ,  B29C64/112

CPC分类号： C12M25/16 ,  C12M27/02 ,  C12M33/00 ,  C12N5/0075 ,  C12N11/04 ,  B29C64/112 ,  B33Y80/00 ,  C12N5/0667 ,  C12N2533/5420130101 ,  C12N2533/7420130101 ,  C12N2533/8020130101 ,  C12N2537/1020130101

摘要： Methods for producing microcarriers by ink jetting, comprising propelling a droplet of a solution comprising one or more biomaterials capable of forming a hydrogel and one or more cells, into a liquid medium. Microcarriers produced by such methods, methods in which such microcarriers are used to culture a cell population in a bioreactor and a system for producing microcarriers by ink jetting are also disclosed.

公开(公告)号：EP3431586B1

公开(公告)日：2024-07-10

申请号：EP17759829.9

申请日：2017-02-24

IPC分类号： C12N5/10

CPC分类号： A61K31/573 ,  C12N5/0696 ,  C12N2506/4520130101 ,  C12N5/067 ,  C12N2533/5420130101 ,  C12N5/0671 ,  C12N2501/1220130101 ,  C12N2501/11520130101 ,  C12N2501/15520130101

公开(公告)号：EP4377445A1

公开(公告)日：2024-06-05

申请号：EP22757431.6

申请日：2022-07-27

申请人： Lineage Cell Therapeutics, Inc.

发明人： HAYOUN NEEMAN, Dana ,  WISER, Ofer ,  TIKOTZKI, Ravid ,  ALON, Lilach

IPC分类号： C12N5/0735 ,  C12N5/079

CPC分类号： C12N5/0621 ,  C12N2506/0220130101 ,  C12N2501/1620130101 ,  C12N2500/0220130101 ,  C12N2531/0020130101 ,  C12N2500/3820130101 ,  C12N2533/5220130101 ,  C12N2533/5420130101 ,  C12N2533/9020130101 ,  C12N2501/1520130101 ,  A61K35/30 ,  A61P27/02

公开(公告)号：EP4377444A1

公开(公告)日：2024-06-05

申请号：EP22848834.2

申请日：2022-07-28

申请人： Ramot at Tel-Aviv University Ltd.

发明人： SATCHI-FAINARO, Ronit ,  NEUFELD, Lena

IPC分类号： C12N5/071 ,  C12M1/00 ,  C12N5/079 ,  C12N5/09 ,  G01N33/50 ,  C12M3/06 ,  A61L27/38 ,  C12N5/00 ,  G09B23/00 ,  B29C64/00 ,  A61F2/04 ,  A61L27/36

CPC分类号： G01N33/5011 ,  G01N33/5082 ,  G01N2800/5220130101 ,  C12M29/10 ,  C12M25/14 ,  B33Y10/00 ,  C12N2533/5620130101 ,  C12N2533/5420130101 ,  C12N5/0693 ,  C12N2502/08620130101 ,  C12N2502/2820130101 ,  C12N2503/0220130101 ,  C12N2501/11520130101 ,  C12N2537/1020130101 ,  G09B23/30 ,  G01N33/5058 ,  C12N2513/0020130101

公开(公告)号：EP4299721A3

公开(公告)日：2024-04-24

申请号：EP23208039.0

申请日：2014-05-08

申请人： ProKidney

发明人： BASU, Joydeep ,  BRUCE, Andrew ,  KELLEY, Rusty ,  GUTHRIE, Kelly

IPC分类号： C12N5/071

CPC分类号： C12N5/0697 ,  C12N2513/0020130101 ,  C12N2533/5420130101 ,  A61K35/44 ,  C12N2502/25620130101 ,  C12N2502/2820130101 ,  A61K35/22 ,  A61P13/12 ,  A61P43/00

摘要： Described herein are organoids comprising admixtures of selected bioactive primary renal cells and a bioactive cell population, e.g., an endothelial cell population, e.g. HUVEC cells, and methods of treating a subject in need thereof with such organoids. Further, the isolated renal cells, which may include tubular and erythropoietin (EPO)-producing kidney cell populations, and/or the endothelial cell populations may be of autologous, syngeneic, allogeneic or xenogeneic origin, or any combination thereof. Further provided are methods of treating a subject in need with the organoids.