METHOD OF ASSAYING GLYCOPROTEIN
    1.
    发明公开
    METHOD OF ASSAYING GLYCOPROTEIN 有权
    VERFAHREN ZUM BESTIMMEN VON GLYKOPROTEINEN

    公开(公告)号:EP1223224A1

    公开(公告)日:2002-07-17

    申请号:EP00963012.0

    申请日:2000-09-29

    IPC分类号: C12Q1/26 C12Q1/37 G01N30/88

    摘要: Based on a principle that is different to that of a conventional enzymatic method, the present invention provides a novel method for assaying a glycated protein by a simple procedure, within a short period of time, and with high accuracy, and a reagent kit for assaying used in the method. The method for assaying a glycated protein in a sample is realized by treating a glycated protein-containing sample with protease to liberate a glycated peptide, preferably an α-glycated peptide, particularly preferably an α-glycated dipeptide, from a glycated protein, allowing an oxidase to react with the liberated glycated peptide, and determining the produced hydrogen peroxide.

    摘要翻译: 基于与常规酶法不同的原理,本发明提供了一种通过简单的方法在短时间内和高精度测定糖化蛋白质的新方法,以及用于测定的试剂盒 用于该方法。 用于测定样品中糖基化蛋白质的方法是通过用蛋白酶处理含糖基化蛋白质的样品来实现的,以从糖基化蛋白质释放糖基化肽,优选α-甘氨酸肽,特别优选α-甘氨酸二肽,允许 氧化酶与释放的糖化肽反应,并测定所产生的过氧化氢。

    GLYCATED HEMOGLOBIN OXIDASE VARIANT AND MEASUREMENT METHOD

    公开(公告)号:EP3677681A1

    公开(公告)日:2020-07-08

    申请号:EP18850676.0

    申请日:2018-08-31

    摘要: Provided is a glycated hemoglobin oxidase with small measurement error or without deviation of the measured value from the true value regarding a sample containing glycated abnormal hemoglobin. Provided are a glycated hemoglobin oxidase comprising an amino acid sequence in which the amino acid at the position corresponding to position 113, 109, 106, or 102 of the amino acid sequence of SEQ ID NO: 1 is substituted with an amino acid other than a positively-charged amino acid, such as glutamic acid, alanine, or aspartic acid as well as a method and a reagent kit for measurement of glycated hemoglobin using such glycated hemoglobin oxidase. The glycated hemoglobin is capable of reacting with various genotypes and enables highly accurate measurement of glycated hemoglobin in a sample containing glycated abnormal hemoglobin.

    DISCHARGE CONTAINER
    7.
    发明公开
    DISCHARGE CONTAINER 审中-公开

    公开(公告)号:EP3608240A1

    公开(公告)日:2020-02-12

    申请号:EP18780688.0

    申请日:2018-04-02

    IPC分类号: B65D1/02 B65D1/32 B65D77/06

    摘要: To provide a container including an inner container that is deformed as content decreases, the container being a dispensing container reusable and excellent in an aroma retaining property. To implement such container, a dispensing container (10) includes a container body (13) including a flexible inner container configured to be filled with content and to deflate as the content decreases, and an outer container encompassing the inner container and having an intake hole through which external air is taken into a space between the inner container and the outer container, a discharge cap (15) including a top surface part having a discharge port through which the content is discharged, the discharge cap (15) being mounted on a mouth portion (13a) of the container body (13), and an external air introduction hole that provides communication between the outside and the intake hole. The inner container and the outer container are made of a polyethylene terephthalate resin.