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    TABLETS COMPRISING A HIGH LOAD OF STRONTIUM
    2.
    发明公开
    TABLETS COMPRISING A HIGH LOAD OF STRONTIUM 审中-公开
    具有高载片剂锶

    公开(公告)号：EP1855654A1

    公开(公告)日：2007-11-21

    申请号：EP05799508.6

    申请日：2005-11-07

    申请人： Osteologix A/S

    发明人： CHRISTGAU, Stephan

    IPC分类号： A61K9/20 ,  A61K33/24 ,  A61K31/28

    CPC分类号： A61K33/24 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/28

    摘要： Tablets comprising strontium in the form of a strontium salt such as strontium malonate. The tablets are designed to contain a very high load of the strontium salt (75% w/w or more), which is especially advantageous due to the fact that strontium must be administered in relative high amounts for therapeutic use. Furthermore, the tablets provided by the present invention lead to an improved bioavailability and presents a therapeutic advantage.

    TREATMENTS COMPRISING STRONTIUM FOR RHEUMATIC AND ARTHRITIC DISEASES AND PAIN
    4.
    发明公开
    TREATMENTS COMPRISING STRONTIUM FOR RHEUMATIC AND ARTHRITIC DISEASES AND PAIN 审中-公开
    BEHANDLUNGEN MIT STRONTIUM BEI RHEUMATISCHEN UND ARTHRITISCHEN ERKRANKUNGEN UND SCHMERZEN

    公开(公告)号：EP1758653A2

    公开(公告)日：2007-03-07

    申请号：EP05748542.7

    申请日：2005-06-17

    申请人： Osteologix A/S

    发明人： CHRISTGAU, Stephan ,  HANSEN, Christian ,  NILSSON, Henrik

    IPC分类号： A61P29/00 ,  A61P29/02 ,  A61K31/65 ,  A61K33/24 ,  A61K31/663 ,  A61K31/737 ,  A61K31/519 ,  A61K45/06 ,  A61K31/7008 ,  A61K31/573 ,  A61K31/28

    CPC分类号： A61K31/519 ,  A61K31/28 ,  A61K31/403 ,  A61K31/573 ,  A61K31/65 ,  A61K31/663 ,  A61K31/7008 ,  A61K31/737 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

    摘要： Improved treatments of joint diseases, such as, e.g. osteoarthritis and rheumatoid arthritis, and pain, wherein a strontium-containing compound is administered alone or in combination with one or more second therapeutically and/or prophylactically active substances, selected from the group consisting of bisphosphonates, glucosamine, pallitative agents, analgesic agents, disease modifying anti-rheumatic compounds (DMARDs), selective estrogen receptor modulators (SERMs), aromatase inhibitors, non-steroidal anti-inflammatory agents (NSAIDs), COX-2 inhibitors, COX-3 inhibitors, opioids, inhibitors/antagonists of IL-1, inhibitors/antagonists of TNF-α, inhibitors of matrix metallo-proteinases (MMPs), cathepsin K inhibitors, inhibitors/antagonists of RANK-ligand, statins, glucocorticoids, chondroitin sulphate, NMDA receptor antagonists, inhibitors of interleukin-I converting enzyme, Calcitonin gene related peptide antagonists, glycine antagonists, vanilloid receptor antagonists, inhibitors of inducible nitric oxide synthetase (iNOS), N-acetylcholine receptor agonists, neurokinin antagonists, neuroleptic agents, PAR2 receptor antagonists and anabolic growth factors acting on joint tissue components. Pharmaceutical compositions comprising a strontium-containing compound and a second therapeutically and/or prophylactically active substance as defined above.

    摘要翻译： 改善关节疾病的治疗，例如， 骨关节炎和类风湿性关节炎以及疼痛，其中单独或与一种或多种第二治疗和/或预防活性物质一起施用含锶化合物，所述第二治疗和/或预防活性物质选自二膦酸盐，葡糖胺，缓释剂，止痛剂，疾病 修饰抗风湿化合物（DMARD），选择性雌激素受体调节剂（SERM），芳香酶抑制剂，非甾体抗炎药（NSAID），COX-2抑制剂，COX-3抑制剂，阿片样物质，IL-1抑制剂/拮抗剂 ，TNF-α的抑制剂/拮抗剂，基质金属蛋白酶（MMPs）的抑制剂，组织蛋白酶K抑制剂，RANK-配体的抑制剂/拮抗剂，他汀类，糖皮质激素，硫酸软骨素，NMDA受体拮抗剂，白细胞介素-I转换酶抑制剂， 降钙素基因相关肽拮抗剂，甘氨酸拮抗剂，香草素受体拮抗剂，诱导型一氧化氮合成酶抑制剂（iNOS），N-乙酰 哌啶受体激动剂，神经激肽拮抗剂，精神抑制剂，PAR2受体拮抗剂和作用于关节组织成分的合成代谢生长因子。 包含含锶化合物和如上定义的第二治疗和/或预防活性物质的药物组合物。

    Treating cartilage/bone conditions with water-soluble strontium salts
    6.
    发明公开
    Treating cartilage/bone conditions with water-soluble strontium salts 有权
    on zen zen zen zen zen zen zen zen zen zen zen zen zen zen zen zen zen

    公开(公告)号：EP1745791A2

    公开(公告)日：2007-01-24

    申请号：EP06021612.4

    申请日：2004-05-06

    申请人： Osteologix A/S

    发明人： Hansen, Christian ,  Nilsson, Henrik ,  Andersen, Jens, E. T. ,  Christgau, Stephan

    IPC分类号： A61K33/24 ,  A61P19/08

    CPC分类号： A61K33/24 ,  C07C55/08 ,  C07C55/10 ,  C07C57/145 ,  C07C59/08 ,  C07C59/19 ,  C07C59/347

    摘要： Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such conditions. The compounds are salts of strontium that have a water-solubility of from about 1 g/l to about 100 g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate.
    The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.

    摘要翻译： 用于治疗和/或预防软骨和/或骨骼状况的化合物和药物组合物以及治疗这些病症的方法。 这些化合物是在室温下具有约1g / l至约100g / l水溶性的锶盐，特别是锶的锶或二羧酸盐的氨基酸盐。 新的水溶性锶盐的实例是例如。 谷氨酸锶和α-酮戊二酸锶。 本发明还涉及一种制备谷氨酸锶盐的改进方法。