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公开(公告)号：EP1534305B9
公开(公告)日：2007-03-07
申请号：EP04731317.6
申请日：2004-05-06
申请人： Osteologix A/S
CPC分类号： A61K33/24 , C07C55/08 , C07C55/10 , C07C57/145 , C07C59/08 , C07C59/19 , C07C59/347
摘要： Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water-solubility of from about 1g/l to about 100g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.
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公开(公告)号：EP1534305B1
公开(公告)日：2006-10-18
申请号：EP04731317.6
申请日：2004-05-06
申请人： Osteologix A/S
CPC分类号： A61K33/24 , C07C55/08 , C07C55/10 , C07C57/145 , C07C59/08 , C07C59/19 , C07C59/347
摘要： Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water-solubility of from about 1g/l to about 100g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.
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3.发明授权Controlled-release composition containing a strontium salt 有权Strontiumzubereitung mit kontrollierter Freisetzung
公开(公告)号：EP1622629B1
公开(公告)日：2013-07-10
申请号：EP04731307.7
申请日：2004-05-06
申请人： Osteologix A/S
CPC分类号： A61K33/00 , A61K31/28 , A61K31/592 , A61K31/593 , A61K33/24 , A61K45/06 , A61K2300/00
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4.发明公开HIGH YIELD AND RAPID SYNTHESES METHODS FOR PRODUCING METALLO-ORGANIC SALTS 审中-公开具有产量高金属有机盐的生产的快速合成方法
公开(公告)号：EP1744770A2
公开(公告)日：2007-01-24
申请号：EP05734804.7
申请日：2005-05-05
申请人： Osteologix A/S
IPC分类号： A61K33/24 , A61P19/08 , C07C51/41 , C07C55/08 , C07C59/19 , C07C57/15 , C07C57/145 , C07C53/06 , C07C229/08
CPC分类号： C07C227/18 , C07C51/412 , C07C55/08 , C07C53/06 , C07C229/08 , C07C59/347 , C07C59/19 , C07C57/15 , C07C57/145
摘要： A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.
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公开(公告)号：EP1622629A2
公开(公告)日：2006-02-08
申请号：EP04731307.7
申请日：2004-05-06
申请人： Osteologix A/S
CPC分类号： A61K33/00 , A61K31/28 , A61K31/592 , A61K31/593 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： A controlled release pharmaceutical composition comprising a strontium salt. The invention also relates to the use of a strontium salt for treating a male suffering from diseases and conditions affecting metabolism and/or structural integrity of cartilage and/or bone. The invention also relates to the use of a strontium-containing compound for preventing a cartilage and/or bone condition in a subject, and for the treatment and/or prophylaxis of secondary osteoporosis.
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公开(公告)号：EP1534305A2
公开(公告)日：2005-06-01
申请号：EP04731317.6
申请日：2004-05-06
申请人： Osteologix A/S
CPC分类号： A61K33/24 , C07C55/08 , C07C55/10 , C07C57/145 , C07C59/08 , C07C59/19 , C07C59/347
摘要： Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water-solubility of from about 1g/l to about 100g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.
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