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1.发明授权CRYSTALLINE FORMS OF 3-[5-CHLORO-4-[(2,4-DIFLUOROBENZYL) OXY]-6-OXOPYRIMIDIN-1(6H)-YL]-N-(2-HYDROXYETHYL)-4-METHYLBENZAMIDE 有权-N-（2-羟基乙基）-4-甲基苯甲酰胺 - 3 - [[（2,4-二氟苄基）氧基] -6-氧代嘧啶-1（6H） - 基5-氯-4]的结晶形式
公开(公告)号：EP1802589B1
公开(公告)日：2014-04-09
申请号：EP05787468.7
申请日：2005-10-03
发明人： SELBO, Jon, G.
IPC分类号： C07D239/52 , A61K31/513
CPC分类号： C07D239/22 , C07D239/553
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公开(公告)号：EP2281835A3
公开(公告)日：2011-11-23
申请号：EP10181691.6
申请日：2000-04-06
IPC分类号： C07K14/285 , C07K16/12 , A61K39/102 , A61K35/74 , C12N1/21 , C12N15/31 , C12Q1/18
CPC分类号： A61K39/102 , A61K2039/522 , C07K14/285 , C12N1/20
摘要： Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
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公开(公告)号：EP1654283B1
公开(公告)日：2011-07-13
申请号：EP04700825.5
申请日：2004-01-08
发明人： REIFSNYDER, David H., Chiron Corp., IP - R338 , INLOW, Duane, Chiron Corp., IP - R338 , DORIN, Glen, Chiron Corp., IP - R338 , RIQUELME, Patricio T., Chiron Corp., IP - R338 , COWGILL, Cynthia, Chiron Corporation, IP - R338 , BOLESCH, Doug G., Chiron Corporation, IP - R338 , GUSTAFSON, Mark E., Chiron Corporation, IP - R338
CPC分类号： C07K5/1008 , A61K38/00 , C07K5/1013 , C07K14/8114
摘要： Highly purified preparations of TFPI or TFPI analogs can be prepared using a method that generally involves the following steps: (1) expression of TFPI or TFPI analog in E. coli, (2) isolation of refractile bodies, (3) dissolution of the refractile bodies and refolding of the expressed TFPI or TFPI analog, (4) SP-Sepharose fast flow (FF) chromatography, (5) a first concentration and diafiltration step, (6) Q-Sepharose high (HP) performance chromatography, (7) butyl hydrophobic interaction chromatography (HIC), (8) SP-Sepharose HP chromatography, and (9) a second concentration/diafiltration step. Less than about 12% of the TFPI or TFPI analog molecules in such preparations are modified TFPI or TFPI analog species (i.e., oxidized, carbamylated, acetylated, deamidated, aggregated, or misfolded species).
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4.发明公开(S,S) reboxetine for treating age associated learning and mental disorders 审中-公开（S，S）瑞波西汀用于年龄相关的学习和记忆障碍的治疗
公开(公告)号：EP2087892A3
公开(公告)日：2009-09-30
申请号：EP09161069.1
申请日：2000-06-22
发明人： Wong, Erik, H., F. , Saeeduddin, Ahmed , Marshall, Robert, Clyde , Mcarthur, Robert, Clyde , Birgerson, Lars , Taylor, Duncan, P. , Cetera, Pasquale
IPC分类号： A61K31/5375 , A61P25/00 , A61P25/28
CPC分类号： A61K31/5375 , A61K31/00 , A61K31/537
摘要： The invention provides the use of optically pure (S,S)-reboxetine, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment or prevention of age associated learning and mental disorders.
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5.发明公开(S,S) reboxetine for treating age associated learning and mental disorders 审中-公开（S，S）瑞波西汀治疗年龄相关的学习和精神障碍
公开(公告)号：EP2087892A2
公开(公告)日：2009-08-12
申请号：EP09161069.1
申请日：2000-06-22
发明人： Wong, Erik, H., F. , Saeeduddin, Ahmed , Marshall, Robert, Clyde , Mcarthur, Robert, Clyde , Birgerson, Lars , Taylor, Duncan, P. , Cetera, Pasquale
IPC分类号： A61K31/5375 , A61P25/00 , A61P25/28
CPC分类号： A61K31/5375 , A61K31/00 , A61K31/537
摘要： The invention provides the use of optically pure (S,S)-reboxetine, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment or prevention of age associated learning and mental disorders.
摘要翻译： 本发明提供了光学纯的（S，S） - 瑞波西汀或其药学上可接受的盐在制备用于治疗或预防年龄相关的学习和精神障碍的药物中的用途。
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6.发明授权ALZHEIMER'S DISEASE SECRETASE, APP SUBSTRATES THEREFOR, AND USES THEREFOR 有权阿尔茨海默氏病的分泌APP（淀粉样蛋白VORLAÜFER）衬底体和用途
公开(公告)号：EP1224297B1
公开(公告)日：2009-05-13
申请号：EP00965338.7
申请日：2000-09-22
CPC分类号： C07K14/4711 , C12N9/6478 , C12N2799/026 , C12Q1/37 , G01N2333/96472
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and isolates and assays. An enzyme that cleaves the α-secretase site of APP also is provided. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
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公开(公告)号：EP1461306B1
公开(公告)日：2008-12-24
申请号：EP02793840.6
申请日：2002-10-25
发明人： RICHARDS, Ivan , CAMMARATA, Sue, K. , WEGNER, Craig, D. , HAWLEY, Michael , WARCHOL, Mark, P. , KONTNY, Mark , MOROZOWICH, Walter , KOLBASA, Karen, P. , MOON, Malcolm, W. , BONAFOUX, Dominique , WOLFSON, Sergey, G. , LENNON, Patrick, J.
IPC分类号： C07C211/27 , C07C211/29 , C07C215/54 , C07C215/66 , C07C219/28 , C07D295/02 , C07C217/62 , A61K31/14 , A61K31/452 , A61K31/40 , A61P11/00
CPC分类号： C07D295/096 , C07C215/54 , C07C215/66 , C07C217/62 , C07C219/28 , C07C237/30
摘要： Novel quaternary ammonium compounds of the formula (I) and any stereoisomers thereof, wherein, R1, R2, and R3 independently represent C1-C6 alkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R1, R2 and R3 may form a ring together with the quaternary ammonium nitrogen; R4 represents -H, -CH3, or -CO-R4-1, wherein R4-1 represents -(C1-C4 alkyl), -(C1-C4 alkoxy), or NR4-2R4-3, wherein R4-2 and R4-3 independently represent -H or -(C1-C4 alkyl); R5, R6 and R7 independently represent -H, -OCH3, -OH, -CONH2, -SO2NH2, -F, -Cl, -Br, -I, -CF3, or -(C1-C4 alkyl), optionally substituted with one or two -OH, -(C1-C4 alkoxy), -COOH, or -CO-O-(C1-C3 alkyl); and X represents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.
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公开(公告)号：EP1860117A3
公开(公告)日：2008-09-03
申请号：EP07001710.8
申请日：2000-04-06
IPC分类号： C07K14/285 , C07K16/12 , A61K39/102 , A61K35/74 , C12N1/21 , C12N15/31 , C12Q1/18
CPC分类号： A61K39/102 , A61K2039/522 , C07K14/285 , C12N1/20
摘要： Gram Negative bacterial virulence genes are identified, thereby allowing the identification of novel-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
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公开(公告)号：EP1939297A1
公开(公告)日：2008-07-02
申请号：EP08103073.6
申请日：1999-09-23
发明人： Gurney, Mark E. , Bienkowski, Michael Jerome , Heinrikson, Robert Leroy , Parodi, Luis , Yan, Riqiang
IPC分类号： C12N15/57 , C12N15/62 , C12N15/85 , C12N5/10 , C12N9/64 , C07K19/00 , C07K14/47 , C12N15/12 , C07K16/18 , C12Q1/37 , G01N33/68 , C12N1/21
CPC分类号： C07K14/4711 , C07K2319/00 , C12N9/6478
摘要： The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays.
摘要翻译： 本发明提供用于切割APP蛋白和相关核酸，肽，载体，细胞和细胞分离物和测定的²分泌酶切割位点的酶和酶程序。
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公开(公告)号：EP1301604B1
公开(公告)日：2008-05-28
申请号：EP01955899.8
申请日：2001-07-19
发明人： YAN, Riqian , TOMASSELLI, Alfredo, G. , GURNEY, Mark, E. , EMMONS, Thomas, L. , BIENKOWSKI, Michael, Jerome , HEINRIKSON, Robert, L.
CPC分类号： C07K14/4711 , C07K5/1013 , C07K7/06 , C07K7/08 , C07K14/4702 , C12Q1/37 , G01N2333/96425 , G01N2500/02
摘要： The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
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