公开(公告)号：EP2340002B1

公开(公告)日：2015-03-25

申请号：EP09819771.8

申请日：2009-10-06

申请人： Providence Health System - Oregon ,  Providence And Biomedical Research Services, Inc.

发明人： GUO, Jian, Xin ,  GREGORY, Kenton, W.

IPC分类号： A61F13/02 ,  A61L15/32 ,  A61L15/42 ,  A61F13/00

CPC分类号： A61L15/28 ,  A61F13/00012 ,  A61F13/00063 ,  A61F13/00987 ,  A61F13/00991 ,  A61F13/15577 ,  A61F2013/00106 ,  A61F2013/00314 ,  A61F2013/00472 ,  A61F2013/0054 ,  A61F2013/0071 ,  A61F2013/00719 ,  A61F2013/0074 ,  A61F2013/00757 ,  A61F2013/0091 ,  A61F2013/00931 ,  A61L15/425 ,  A61L15/44 ,  A61L2300/404 ,  A61L2300/408 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2430/34 ,  B29C44/005 ,  B29K2005/00 ,  B29K2105/045 ,  B29K2995/0037 ,  B29L2031/753 ,  C08L5/08

公开(公告)号：EP2340002A1

公开(公告)日：2011-07-06

申请号：EP09819771.8

申请日：2009-10-06

申请人： Providence Health System - Oregon ,  Providence And Biomedical Research Services, Inc.

发明人： GUO, Jian, Xin ,  GREGORY, Kenton, W.

IPC分类号： A61F13/02

CPC分类号： A61L15/28 ,  A61F13/00012 ,  A61F13/00063 ,  A61F13/00987 ,  A61F13/00991 ,  A61F13/15577 ,  A61F2013/00106 ,  A61F2013/00314 ,  A61F2013/00472 ,  A61F2013/0054 ,  A61F2013/0071 ,  A61F2013/00719 ,  A61F2013/0074 ,  A61F2013/00757 ,  A61F2013/0091 ,  A61F2013/00931 ,  A61L15/425 ,  A61L15/44 ,  A61L2300/404 ,  A61L2300/408 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2430/34 ,  B29C44/005 ,  B29K2005/00 ,  B29K2105/045 ,  B29K2995/0037 ,  B29L2031/753 ,  C08L5/08

摘要： The invention provides a solid foam wound dressing useful for hemorrhage control and wound repair, as well as methods for making such a wound dressing.

公开(公告)号：EP1113765A1

公开(公告)日：2001-07-11

申请号：EP99941241.4

申请日：1999-08-18

申请人： Providence Health System - Oregon

发明人： XIE, Hua

IPC分类号： A61F2/06

CPC分类号： A61L31/18 ,  A61B90/39 ,  A61B2017/00004 ,  A61B2017/00508 ,  A61F2/82 ,  A61L31/043 ,  A61L31/044 ,  A61L31/046 ,  A61L31/16 ,  A61L2300/00 ,  A61L31/148 ,  A61L31/14 ,  A61L31/005

摘要： An insertable stent (10) is provided for joining together, and facilitating healing of adjacent tissues (18, 20). Typically, the tissues are mammalian tissues. The inserted stent is made from completely non-toxic, bio-compatible and blood compatible materials. Each of the tissues employed herein defines an internal cavity (22). The insertable stent body defines a bore. The bore permits fluid to pass through the inserted stent body (12). In use, the inserted stent (12) is introduced into the internal cavities of the tissues (22). The inserted stent body fits within the confines of, and in contact with, each of the adjacent tissues. Typically, at least a portion of the inserted stent body (12) is fusible to the adjacent tissues (18, 20) for facilitating healing of these tissues.

公开(公告)号：EP2608811A1

公开(公告)日：2013-07-03

申请号：EP11764011.0

申请日：2011-08-26

申请人： Providence Health System - Oregon ,  The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Portland State University

发明人： HU, Hong-Ming ,  LI, Haiyan ,  JIAO, Jun

IPC分类号： A61K47/48 ,  A61P35/00

CPC分类号： A61K47/48238 ,  A61K45/06 ,  A61K47/6923 ,  A61K47/6929

摘要： Disclosed are nanoparticle-autophagosome conjugates capable of stimulating an immune response against a target antigen, wherein the nanoparticle-autophagosome conjugates include autophagosome(s) covalently attached to alumina nanoparticle(s), wherein the autophagosome includes defective ribosomal products (DRiPs) of the target antigen. Also disclosed are immunogenic compositions including these conjugates and/or antigen- presenting cells loaded with these conjugates, and methods of stimulating an immune response against a target antigen by administration of immunogenic compositions including these conjugates and/or antigen-presenting cells loaded with these conjugates.

公开(公告)号：EP1704225B1

公开(公告)日：2017-05-31

申请号：EP04815198.9

申请日：2004-12-23

申请人： Tricol Biomedical, Inc. ,  PROVIDENCE HEALTH SYSTEM-OREGON d/b/a ST. VINCENT MEDICAL CENTER

发明人： MCCARTHY, Simon, J. ,  GREGORY, Kenton, W. ,  WIESMANN, William, P. ,  CAMPBELL, Todd, D.

IPC分类号： A61K31/74 ,  A61F13/15 ,  F26B5/06 ,  B29C67/20 ,  A61M31/00

CPC分类号： A61F13/0203 ,  A61F5/40 ,  A61F13/00063 ,  A61F13/0253 ,  A61F13/0256 ,  A61F13/0276 ,  A61F13/0289 ,  A61F13/36 ,  A61F17/00 ,  A61F2013/00106 ,  A61F2013/00221 ,  A61F2013/00463 ,  A61F2013/00468 ,  A61F2013/00472 ,  A61F2013/0054 ,  A61F2013/00659 ,  A61F2013/00676 ,  A61F2013/0071 ,  A61F2013/00719 ,  A61F2013/00931 ,  A61L15/28 ,  A61L15/425 ,  A61L2400/04 ,  C08L1/00 ,  C08L5/08

公开(公告)号：EP1704225A2

公开(公告)日：2006-09-27

申请号：EP04815198.9

申请日：2004-12-23

申请人： Hemcon, Inc. ,  Providence Health System-Oregon

发明人： MCCARTHY, Simon, J. ,  GREGORY, Kenton, W. ,  WIESMANN, William, P. ,  CAMPBELL, Todd, D.

IPC分类号： C12N1/00

CPC分类号： A61F13/0203 ,  A61F5/40 ,  A61F13/00063 ,  A61F13/0253 ,  A61F13/0256 ,  A61F13/0276 ,  A61F13/0289 ,  A61F13/36 ,  A61F17/00 ,  A61F2013/00106 ,  A61F2013/00221 ,  A61F2013/00463 ,  A61F2013/00468 ,  A61F2013/00472 ,  A61F2013/0054 ,  A61F2013/00659 ,  A61F2013/00676 ,  A61F2013/0071 ,  A61F2013/00719 ,  A61F2013/00931 ,  A61L15/28 ,  A61L15/425 ,  A61L2400/04 ,  C08L1/00 ,  C08L5/08

摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.

公开(公告)号：EP1198196A1

公开(公告)日：2002-04-24

申请号：EP00950363.2

申请日：2000-07-14

申请人： Providence Health System-Oregon

发明人： JACQUES, Steven, L.

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/1495 ,  G01N21/274 ,  G01N21/3151

摘要： A method for determining an arterial blood oxygen saturation level according to this invention includes measuring the light transmittance through tissue of light of a first wavelength, and a second wavelength (20). A steady-state component of the measured light transmission is used to select an appropriate calibration curve (30). A pulsatile component of the measured light transmission is used to determine the arterial blood oxygen saturation level using the selected calibration curve (40). An oximetry system is also provided.

公开(公告)号：EP1401352B1

公开(公告)日：2012-03-21

申请号：EP02739871.8

申请日：2002-06-14

申请人： Gregory, Kenton W. ,  Providence Health System - Oregon

发明人： GREGORY, Kenton, W. ,  McCARTHY, Simon

IPC分类号： A61F2/00 ,  A61L15/28 ,  A61L15/42

CPC分类号： A61L15/425 ,  A61F13/00012 ,  A61F13/00034 ,  A61F13/00987 ,  A61F13/00995 ,  A61F13/15203 ,  A61F2013/00106 ,  A61F2013/00463 ,  A61F2013/00468 ,  A61F2013/00472 ,  A61F2013/00536 ,  A61F2013/0054 ,  A61F2013/00931 ,  A61L15/28 ,  A61L2400/04 ,  C08L5/08

摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using a producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing is formed of a biomaterial comprising chitosan for controlling severe bleeding. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot information at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.

公开(公告)号：EP2279012A1

公开(公告)日：2011-02-02

申请号：EP09739250.0

申请日：2009-05-01

申请人： Providence Health System-Oregon d/b/a Providence St. Vincent Medical Center

发明人： LUCCHESI, Lisa ,  XIE, Hua

IPC分类号： A61L15/00

CPC分类号： A61L15/28 ,  C08L5/08

摘要： The present invention provides an absorbent wound dressing assembly that can be used to stanch, seal, or stabilize a site of tissue injury, tissue trauma, or tissue access. The wound dressing assembly is flexible so that it can be adapted and used to fit in narrow and small wound sites. Generally the wound dressing assembly comprises a flexible carrier material that is impregnated with a non-mammalian material for control of severe bleeding. The preferred non-mammalian material is poly [β- (1→4) -2-amino-2-deoxy-D-glucopyranose] more commonly referred to as chitosan.

公开(公告)号：EP1494616A2

公开(公告)日：2005-01-12

申请号：EP03714341.9

申请日：2003-03-21

申请人： Providence Health System-Oregon

发明人： XIE, Hua ,  BUCKLEY, Lisa, A.

IPC分类号： A61F2/06

CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2220/0075 ,  A61F2230/0026

摘要： A bioprosthetic valve graft (1) comprises a valve frame (10) and valve flaps (12), the latter acting to open or close a valve aperture (14) to directionally control fluid flow through the bioprosthesis (1). The bioprosthetic valve graft (1) comprises a biomaterial suturelessly bonded to the valve frame (10), avoiding sutures and substantially reducing medical complications in implantations.