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1.发明公开
公开(公告)号：EP1704225A2
公开(公告)日：2006-09-27
申请号：EP04815198.9
申请日：2004-12-23
IPC分类号： C12N1/00
CPC分类号： A61F13/0203 , A61F5/40 , A61F13/00063 , A61F13/0253 , A61F13/0256 , A61F13/0276 , A61F13/0289 , A61F13/36 , A61F17/00 , A61F2013/00106 , A61F2013/00221 , A61F2013/00463 , A61F2013/00468 , A61F2013/00472 , A61F2013/0054 , A61F2013/00659 , A61F2013/00676 , A61F2013/0071 , A61F2013/00719 , A61F2013/00931 , A61L15/28 , A61L15/425 , A61L2400/04 , C08L1/00 , C08L5/08
摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using and producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing for controlling severe bleeding is formed of a biomaterial comprising chitosan, a hydrophilic polymer, a polyacrylic polymer or a combination thereof. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot formation at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.
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2.发明授权WOUND DRESSING AND METHOD FOR CONTROLLING SEVERE, LIFE-THREATENING BLEEDING 有权伤口敷料和用于控制严重，生命威胁性出血的方法
公开(公告)号：EP1704225B1
公开(公告)日：2017-05-31
申请号：EP04815198.9
申请日：2004-12-23
CPC分类号： A61F13/0203 , A61F5/40 , A61F13/00063 , A61F13/0253 , A61F13/0256 , A61F13/0276 , A61F13/0289 , A61F13/36 , A61F17/00 , A61F2013/00106 , A61F2013/00221 , A61F2013/00463 , A61F2013/00468 , A61F2013/00472 , A61F2013/0054 , A61F2013/00659 , A61F2013/00676 , A61F2013/0071 , A61F2013/00719 , A61F2013/00931 , A61L15/28 , A61L15/425 , A61L2400/04 , C08L1/00 , C08L5/08
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公开(公告)号：EP2340002B1
公开(公告)日：2015-03-25
申请号：EP09819771.8
申请日：2009-10-06
CPC分类号： A61L15/28 , A61F13/00012 , A61F13/00063 , A61F13/00987 , A61F13/00991 , A61F13/15577 , A61F2013/00106 , A61F2013/00314 , A61F2013/00472 , A61F2013/0054 , A61F2013/0071 , A61F2013/00719 , A61F2013/0074 , A61F2013/00757 , A61F2013/0091 , A61F2013/00931 , A61L15/425 , A61L15/44 , A61L2300/404 , A61L2300/408 , A61L2300/412 , A61L2300/418 , A61L2400/04 , A61L2430/34 , B29C44/005 , B29K2005/00 , B29K2105/045 , B29K2995/0037 , B29L2031/753 , C08L5/08
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公开(公告)号：EP2340002A1
公开(公告)日：2011-07-06
申请号：EP09819771.8
申请日：2009-10-06
IPC分类号： A61F13/02
CPC分类号： A61L15/28 , A61F13/00012 , A61F13/00063 , A61F13/00987 , A61F13/00991 , A61F13/15577 , A61F2013/00106 , A61F2013/00314 , A61F2013/00472 , A61F2013/0054 , A61F2013/0071 , A61F2013/00719 , A61F2013/0074 , A61F2013/00757 , A61F2013/0091 , A61F2013/00931 , A61L15/425 , A61L15/44 , A61L2300/404 , A61L2300/408 , A61L2300/412 , A61L2300/418 , A61L2400/04 , A61L2430/34 , B29C44/005 , B29K2005/00 , B29K2105/045 , B29K2995/0037 , B29L2031/753 , C08L5/08
摘要： The invention provides a solid foam wound dressing useful for hemorrhage control and wound repair, as well as methods for making such a wound dressing.
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公开(公告)号：EP1401352B1
公开(公告)日：2012-03-21
申请号：EP02739871.8
申请日：2002-06-14
CPC分类号： A61L15/425 , A61F13/00012 , A61F13/00034 , A61F13/00987 , A61F13/00995 , A61F13/15203 , A61F2013/00106 , A61F2013/00463 , A61F2013/00468 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/00931 , A61L15/28 , A61L2400/04 , C08L5/08
摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using a producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing is formed of a biomaterial comprising chitosan for controlling severe bleeding. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot information at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.
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6.发明公开
公开(公告)号：EP1401352A2
公开(公告)日：2004-03-31
申请号：EP02739871.8
申请日：2002-06-14
IPC分类号： A61F2/00
CPC分类号： A61L15/425 , A61F13/00012 , A61F13/00034 , A61F13/00987 , A61F13/00995 , A61F13/15203 , A61F2013/00106 , A61F2013/00463 , A61F2013/00468 , A61F2013/00472 , A61F2013/00536 , A61F2013/0054 , A61F2013/00931 , A61L15/28 , A61L2400/04 , C08L5/08
摘要： This invention is directed to advanced hemorrhage control wound dressings, and methods of using a producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing is formed of a biomaterial comprising chitosan for controlling severe bleeding. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot information at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.
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7.发明公开METHODS FOR PRODUCING LAMINATED ELASTIN, ELASTIN-BASED MATERIALS AND TROPOELASTIN PRODUCTS FOR REPAIRING AND/OR REPLACING TISSUE 审中-公开材料层合弹性蛋白的生产方法，ON ELASTIN基于FOR组织恢复和更换材料与TROPOELASTINPRODUKTE
公开(公告)号：EP1196510A1
公开(公告)日：2002-04-17
申请号：EP00937853.0
申请日：2000-05-25
发明人： GREGORY, Kenton, W.
IPC分类号： C09J101/00
CPC分类号： B32B9/02 , A61L24/06 , A61L27/227 , A61L27/40 , B32B2307/5825 , B32B2307/7265 , B32B2535/00 , B32B2556/00 , C08L35/04
摘要： The invention is directed to a method including the steps of providing at least one layer of unlaminated elastin or unlaminated elastin-based materials or unlaminated tropoelastin materials. Then, the unlaminated elastin or unlaminated elastin-based materials or unlaminated tropoelastin materials is subjected to heating and pressing steps. The pressing step of the present invention is preferably conducted in the presence of steam. The laminated elastin or laminated elastin-based materials or laminated tropoelastin materials preferably comprises a multi-layer composite material. Typically, the step of adhering with an adhesive material the laminated elastin or laminated elastin-based materials or laminated tropoelastin materials is employed in order to achieve a water-tight engagement with the tissue substrate. A biogradable cyanocrylate glue is generally used in order to achieve quick and easy way to secure the patch in place and provide watertight fusion instantly. Preferably, the adhesive material comprises an alkoxy alkyl cyanoacrylate material.
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8.发明授权METHOD OF PRODUCING ELASTIN, ELASTIN-BASED BIOMATERIALS AND TROPOELASTIN MATERIALS 有权弹性蛋白的生产方法，对基于弹性蛋白和生物材料原弹性蛋白材料
公开(公告)号：EP1049482B1
公开(公告)日：2006-03-01
申请号：EP98966114.5
申请日：1998-12-29
发明人： GREGORY, Kenton, W.
CPC分类号： A61F2/0063 , A61F2/0077 , A61F2/042 , A61F2/06 , A61F2/07 , A61F2/82 , A61F2/91 , A61K38/00 , A61L27/227 , A61L27/3683 , A61L27/38 , A61L27/50 , A61L31/005 , A61L31/047 , A61L31/14 , A61L2400/02 , B32B5/02 , B32B9/02 , C07K14/78
摘要： A method is provided for producing elastin or elastin-based materials or tropoelastin materials which have a substantially reduced level of calcification. These materials are typically capable of being formed into a fused layer. The subject method comprises providing unreacted elastin or elastin-based biomaterials or tropoelastin materials, and pretreating the unreacted elastin or elastin-based biomaterials or tropoelastin materials with an aliphatic alcohol prior to reaction thereof. In this way, when the pretreated unreacted elastin or elastin-based biomaterials or tropoelastin materials is reacted subsequently, elastin or elastin-based materials or tropoelastin materials are produced which have a substantially reduced level of calcification as compared with elastin or elastin-based materials or tropoelastin materials produced from non-pretreated counterpart unreacted elastin or elastin-based biomaterials or tropoelastin materials.
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公开(公告)号：EP0792125B1
公开(公告)日：2004-11-24
申请号：EP95944462.1
申请日：1995-04-04
CPC分类号： B32B5/02 , A61F2/0063 , A61F2/06 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/072 , A61F2002/075 , A61F2230/0078 , A61L27/227 , B32B5/024 , B32B9/02 , B32B27/12 , B32B27/306 , B32B27/322 , B32B27/36 , B32B27/40 , B32B2305/188 , B32B2307/56 , B32B2323/00 , B32B2327/18 , B32B2329/04 , B32B2367/00 , B32B2375/00 , B32B2535/00 , Y10S128/08 , Y10S623/901 , Y10S623/92
摘要： The present invention relates to an elastin-based biomaterial and to a method of using same to effect tissue repair or replacement. The invention further relates to a method of securing the biomaterial to existing tissue.
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10.发明公开ANTIMICROBIAL BARRIERS, SYSTEMS, AND METHODS FORMED FROM HYDROPHILIC POLYMER STRUCTURES SUCH AS CHITOSAN 审中-公开抗菌屏障，系统和亲水性聚合物结构壳聚糖方法
公开(公告)号：EP1830755A2
公开(公告)日：2007-09-12
申请号：EP05854846.2
申请日：2005-12-20
申请人： Hemcon, Inc.
CPC分类号： A61L15/46 , A61F5/445 , A61F13/00034 , A61F13/00063 , A61F2013/00106 , A61F2013/00251 , A61F2013/00327 , A61F2013/00463 , A61F2013/00472 , A61F2013/0054 , A61F2013/00548 , A61F2013/00859 , A61F2013/0091 , A61F2013/00931 , A61K31/722 , A61L15/28 , A61L15/425 , A61L33/08 , A61L2300/404 , A61L2300/602 , A61L2400/04 , C08L5/08
摘要： An antimicrobial barrier comprising a structure including a chitosan biomaterial. The antimicrobial barrier can be used, e.g., (i) stanch, seal, or stabilize a site of tissue injury, tissue trauma, or tissue access; or (ii) form an anti-microbial barrier; or (iii) form an antiviral patch; or (iv) intervene in a bleeding disorder; or (v) release a therapeutic agent; or (vi) treat a mucosal surface; or (vii) combinations thereof. The structure of the antimicrobial barrier may be densified by compression.
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