利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

16 条记录 (耗时 0.018 秒)

    POLYOXAZOLINE ANTIBODY DRUG CONJUGATES
    7.
    发明公开
    POLYOXAZOLINE ANTIBODY DRUG CONJUGATES 审中-公开

    公开(公告)号：EP3180388A4

    公开(公告)日：2018-04-04

    申请号：EP15826412

    申请日：2015-07-31

    申请人： SERINA THERAPEUTICS INC

    发明人： MOREADITH RANDALL ,  BENTLEY MICHAEL ,  FANG ZHIHAO ,  VIEGAS TACEY

    IPC分类号： A61K47/60 ,  A61P35/00

    CPC分类号： A61K47/48384 ,  A61K47/557 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6883 ,  A61K47/6889

    摘要： In the present disclosure, polymer conjugates, including polymer-antibody-drug conjugates (polymer ADCs) are described, as well as the use of such conjugates to treat human disease. The polymer conjugates can contain a large number of polymer-bound agents, thus effectively increasing the drug antibody ration (DAR) of the antibody significantly beyond the currently available technology. This may be of particular importance when antibodies to low density antigens are used as target antibodies. The described polymer-ADCs have improved pharmacokinetics and solubility relative to traditional ADCs. The linker between agent and the polymer can be tailored to provide release of toxin at the desired site and under the desired conditions within the tumor. An additional feature of the polymer-ADCs of the current disclosure is that a purification moiety can be attached to the polymer backbone to provide ease of purification of the polymer-ADCs.

    POLYOXAZOLINE ANTIBODY DRUG CONJUGATES
    8.
    发明公开
    POLYOXAZOLINE ANTIBODY DRUG CONJUGATES 审中-公开
    聚恶唑啉抗体药物偶联物

    公开(公告)号：EP3180388A1

    公开(公告)日：2017-06-21

    申请号：EP15826412.7

    申请日：2015-07-31

    申请人： Serina Therapeutics, Inc.

    发明人： MOREADITH, Randall ,  BENTLEY, Michael ,  FANG, Zhihao ,  VIEGAS, Tacey

    IPC分类号： C08G73/06 ,  C08G69/00 ,  C08G75/02

    CPC分类号： A61K47/48384 ,  A61K47/557 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6883 ,  A61K47/6889

    摘要： In the present disclosure, polymer conjugates, including polymer-antibody-drug conjugates (polymer ADCs) are described, as well as the use of such conjugates to treat human disease. The polymer conjugates can contain a large number of polymer-bound agents, thus effectively increasing the drug antibody ration (DAR) of the antibody significantly beyond the currently available technology. This may be of particular importance when antibodies to low density antigens are used as target antibodies. The described polymer-ADCs have improved pharmacokinetics and solubility relative to traditional ADCs. The linker between agent and the polymer can be tailored to provide release of toxin at the desired site and under the desired conditions within the tumor. An additional feature of the polymer-ADCs of the current disclosure is that a purification moiety can be attached to the polymer backbone to provide ease of purification of the polymer-ADCs.

    摘要翻译： 在本公开中，描述了聚合物缀合物，包括聚合物 - 抗体 - 药物缀合物（聚合物ADC），以及这种缀合物用于治疗人类疾病的用途。 聚合物缀合物可以含有大量聚合物结合剂，因此有效地增加了抗体的药物抗体比（DAR），超出了目前可用的技术。 当将低密度抗原的抗体用作靶抗体时，这可能特别重要。 所述聚合物-ADC相对于传统ADC具有改善的药代动力学和溶解度。 试剂和聚合物之间的连接体可以定制为在期望的部位和肿瘤内的期望的条件下释放毒素。 本公开内容的聚合物-ADCs的另一个特征是纯化部分可以连接到聚合物主链上以提供聚合物-ADC的纯化容易性。

    MULTIFUNCTIONAL FORMS OF POLYOXAZOLINE COPOLYMERS AND DRUG COMPOSITIONS COMPRISING THE SAME
    9.
    发明公开
    MULTIFUNCTIONAL FORMS OF POLYOXAZOLINE COPOLYMERS AND DRUG COMPOSITIONS COMPRISING THE SAME 有权
    WIRKSTOFFZUSAMMENSETZUNGEN DAMIT的多功能型氟聚氧乙烯

    公开(公告)号：EP3042922A1

    公开(公告)日：2016-07-13

    申请号：EP16154587.6

    申请日：2009-01-12

    申请人： Serina Therapeutics, Inc.

    发明人： HARRIS, J. Milton ,  YOON, Kunsang ,  BENTLEY, Michael

    IPC分类号： C08G69/44

    CPC分类号： C08G73/0233 ,  C08G73/028

    摘要： The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.

    摘要翻译： 本公开提供了具有两个或三个也是化学正交的反应性官能团的2-取代-2-恶唑啉的共聚物。 所述的共聚物可以是无规共聚物，嵌段共聚物或无规嵌段共聚物构型的混合物。 此外，本公开提供了用于合成上述聚合物并与分子例如靶向，诊断和治疗剂缀合的新方法。