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    DETECTION OF PROPER INSEMINATION TIME BY MULTIPLE PREGNANCY MARKER PATTERN (MPMP) RECOGNITION
    6.
    发明公开
    DETECTION OF PROPER INSEMINATION TIME BY MULTIPLE PREGNANCY MARKER PATTERN (MPMP) RECOGNITION 审中-公开
    通过多次妊娠记分模式（MPMP）识别检测正确的受孕时间

    公开(公告)号：EP3220146A1

    公开(公告)日：2017-09-20

    申请号：EP16161039.9

    申请日：2016-03-18

    申请人： Stichting Wageningen Research

    发明人： TE PAS, Marinus Frederik Willem ,  WOELDERS, Henri ,  BOUWMAN, Aniek Cornelia ,  HULSEGGE, Berendina

    IPC分类号： G01N33/68 ,  G01N33/74

    CPC分类号： G01N33/689 ,  G01N33/743

    摘要： The invention relates to methods for pregnancy and non-pregnancy testing and also relates to methods allowing determination of proper insemination time to establish pregnancy. The invention provides method to determine whether an inseminated female mammal is pregnant prior to a point in time at which said mammal would be expected to ovulate if non-pregnant, said method comprising taking a biological sample from said mammal prior to said point in time and testing said sample for the presence of a multiple pregnancy marker pattern (MPMP). It is preferred that said sample is tested for the relative expression of progesterone and of at least one marker selected from a group of marker proteins that each contribute to a significantly differential marker expression pattern related to the status pregnancy and is tested to determine whether said mammal is non-pregnant and may be re-inseminated.

    摘要翻译： 本发明涉及用于妊娠和非妊娠测试的方法，还涉及允许确定适当的受精时间以建立妊娠的方法。 本发明提供了确定授精的雌性哺乳动物是否在所述哺乳动物如果未怀孕的情况下预期排卵的时间点之前怀孕的方法，所述方法包括在所述时间点之前从所述哺乳动物取得生物样品，和 测试所述样品是否存在多胎妊娠标记物模式（MPMP）。 优选所述样品测试孕酮和选自一组标记蛋白的相对表达，每组标记蛋白均有助于与状态妊娠有关的显着差异的标记表达模式，并测试以确定所述哺乳动物 没有怀孕，可能会重新授精。