公开(公告)号：EP2691104A4

公开(公告)日：2014-10-15

申请号：EP12764414

申请日：2012-03-21

申请人： TELIK INC

发明人： WICK MICHAEL M

IPC分类号： A61K38/06 ,  A61K38/07 ,  A61P35/02

CPC分类号： A61K31/216 ,  A61K31/454 ,  A61K31/573 ,  A61K31/664 ,  A61K31/69 ,  A61K31/704 ,  A61K35/28 ,  A61K38/212 ,  A61K45/06 ,  A61K2300/00 ,  A61K31/4745

摘要： Ezatiostat is useful for inhibiting multiple myeloma cell proliferation and treating multiple myeloma, alone or when added together with another anti-myeloma drug.

公开(公告)号：EP2554682A1

公开(公告)日：2013-02-06

申请号：EP12179172.7

申请日：2012-08-03

申请人： Telik, Inc.

发明人： Brown, Gail L.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

摘要： This invention relates to methods, assays, devices and systems for identifying patients having a myelodysplastic syndrome for treatment with ezatiostat or a salt thereof, or evaluating the patient's response possibility to the treatment by measuring and evaluating the patient's gene expression profile. This invention also relates to methods of treating myelodysplastic syndromes.

摘要翻译： 本发明涉及用于鉴定患有骨髓增生异常综合征的患者的方法，测定，装置和系统，用于治疗受体激动剂或其盐，或通过测量和评估患者的基因表达谱来评估患者对治疗的反应可能性。 本发明还涉及治疗骨髓增生异常综合征的方法。

公开(公告)号：EP2392330A1

公开(公告)日：2011-12-07

申请号：EP11168379.3

申请日：2011-06-01

申请人： Telik, Inc.

发明人： Brown, Gail L. ,  Meng, Lixin

IPC分类号： A61K31/454 ,  A61K38/06 ,  A61K9/00 ,  A61K9/20 ,  A61P35/00

CPC分类号： A61K38/05 ,  A61K31/454 ,  A61K38/06 ,  A61K2300/00

摘要： The invention generally relates to compositions for use in treating myelodysplastic syndrome. In one embodiment, the invention relates to compositions comprising ezatiostat or a salt thereof and lenalidomide for use in treating myelodysplastic syndrome.

摘要翻译： 本发明一般涉及用于治疗骨髓增生异常综合征的组合物。 在一个实施方案中，本发明涉及包含用于治疗骨髓增生异常综合征的镇痛药或其盐和来那度胺的组合物。

公开(公告)号：EP1235072B1

公开(公告)日：2007-04-11

申请号：EP02009879.4

申请日：1995-01-05

申请人： TELIK, INC.

发明人： Kauvar, Lawrence M. ,  Villar, Hugo O.

IPC分类号： G01N33/53 ,  G01N33/68

CPC分类号： G01N33/53 ,  G01N33/5308 ,  G01N33/68 ,  G01N33/94 ,  G06F19/704 ,  G06F19/706 ,  Y10S436/809

公开(公告)号：EP1278759B1

公开(公告)日：2005-12-21

申请号：EP01935025.5

申请日：2001-05-02

申请人： TELIK, INC.

发明人： HERR, Jason, R. ,  LUM, Robert, T. ,  SCHOW, Steven, R. ,  MENG, Fanying ,  KOZLOWSKI, Michael, R. ,  ZHICHKIN, Pavel

IPC分类号： C07F9/24 ,  A61K31/664 ,  A61P35/04

CPC分类号： C07F9/2458 ,  C07F9/2408

摘要： The present invention relates to chemical compounds, methods of treatment, pharmaceutical compositions, and processes for their preparation. The compounds possess anti-tumor activities or are capable of being modified to have anti-tumor activities, and therefore, this invention particularly relates to the use of the compounds in methods for the treatment of tumors and especially for the treatment of cancer, as well as to the processes for their preparation.

公开(公告)号：EP1289936B1

公开(公告)日：2004-10-20

申请号：EP01941753.4

申请日：2001-06-01

申请人： TELIK, INC.

发明人： PATTERSON, John ,  PARK, Jeong, Weong ,  LUM, Robert, T. ,  SPEVAK, Wayne, R.

IPC分类号： C07C237/42 ,  C07C237/40 ,  C07C233/81 ,  C07C235/56 ,  C07C309/61 ,  A61K31/196 ,  A61K31/24 ,  C07C231/02

CPC分类号： C07C233/81 ,  C07C233/88 ,  C07C235/56 ,  C07C235/64 ,  C07C235/84 ,  C07C237/40 ,  C07C237/42 ,  C07C309/51 ,  C07C309/61 ,  C07D317/60

摘要： The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, methods of treatment administering these compounds to mammalian hosts, and processes for their preparation. Specifically, the invention relates to a means to enhance insulin-dependent glucose uptake. More specifically, the invention concerns compounds and pharmaceutical compositions that activate the insulin receptor kinase, which leads to increased sensitivity to insulin and an increase in glucose uptake, as well as processes for the preparation of the compounds. The invention also specifically concerns methods for treating humans with hyperglycemia, especially for the treatment of Type II diabetes.

公开(公告)号：EP1278759A1

公开(公告)日：2003-01-29

申请号：EP01935025.5

申请日：2001-05-02

申请人： TELIK, INC.

发明人： HERR, Jason, R. ,  LUM, Robert, T. ,  SCHOW, Steven, R. ,  MENG, Fanying ,  KOZLOWSKI, Michael, R. ,  ZHICHKIN, Pavel

IPC分类号： C07F9/24 ,  A61K31/664 ,  A61P35/04

CPC分类号： C07F9/2458 ,  C07F9/2408

摘要： The present invention relates to chemical compounds, methods of treatment, pharmaceutical compositions, and processes for their preparation. The compounds possess anti-tumor activities or are capable of being modified to have anti-tumor activities, and therefore, this invention particularly relates to the use of the compounds in methods for the treatment of tumors and especially for the treatment of cancer, as well as to the processes for their preparation.

公开(公告)号：EP1200396A1

公开(公告)日：2002-05-02

申请号：EP00952351.5

申请日：2000-07-28

申请人： TELIK, INC.

发明人： SPEVAK, Wayne, R. ,  SONGYUAN, Shi ,  PRASAD, V., V., S., V., Manchem ,  KOZLOWSKI, Michael, R. ,  SCHOW, Steven, R. ,  LUM, Robert, T. ,  ROBINSON, Louise ,  PARK, Jeong, Weong

IPC分类号： C07C309/51 ,  C07C309/59 ,  C07D213/81 ,  C07D213/82 ,  C07D307/85 ,  C07C311/21 ,  C07C311/29 ,  C07C311/13 ,  C07C237/42 ,  A61K31/16 ,  A61K31/18 ,  A61K31/33

CPC分类号： C07D241/44 ,  C07C237/42 ,  C07C309/51 ,  C07C309/59 ,  C07C311/13 ,  C07C311/21 ,  C07C311/29 ,  C07D213/81 ,  C07D213/82 ,  C07D215/48 ,  C07D307/68 ,  C07D307/85

摘要： Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds are provided. Compounds of formula (1) where: R?1 and R2¿ are, independently, hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, R3 is a substituent on the B ring; and is -SO¿2OR?6, -C(O)OR6, -SO2NR62-C(O)NR62 or tetrazolyl; the linker -WY- between the naphthyl and phenyl intersects the A ring of the naphthyl and is, independently, -C(O)NR?7-, -NR7¿C(O)-, -C(O)O-, -OC(O)-, -CH=CH-, -NR7CH2-, -CH2NR?7-, -NR7C(O)NR7- -NR7¿C(O)O-, -OC(O)NR?7-, -NR7SO¿2O-, -OSO2NR7-, -OC(O)O-, -SO¿2?NR?7-, -NR7SO¿2-, -OSO2-, or -SO2O-; each R?6 and R7¿ is, independently, hydrogen or lower alkyl; optionally in the form of single stereoisomers or mixtures of stereoisomers, or the pharmaceutically acceptable salts thereof; are useful in methods of stimulating the kinase activity of the insulin receptor, enhancing the activation of the insulin receptor by insulin, and stimulating the uptake of glucose into cells. A variety of antidiabetic compounds and pharmaceutical compositions comprising the antidiabetic compounds are also disclosed.

公开(公告)号：EP2576590A1

公开(公告)日：2013-04-10

申请号：EP11707986.3

申请日：2011-03-04

申请人： Telik, Inc.

发明人： PARENT, Stephan, D. ,  SCHOW, Steven, R.

IPC分类号： C07K5/02 ,  A61K38/06 ,  A61P35/00

CPC分类号： C07K5/0215 ,  A61K38/00

摘要： Crystalline ezatiostat hydrochloride ansolvate form D is more stable and/or more soluble than various solvated crystalline polymorphic forms of ezatiostat hydrochloride.

公开(公告)号：EP1607399B1

公开(公告)日：2010-01-20

申请号：EP05020467.6

申请日：2001-05-02

申请人： TELIK, INC.

发明人： Herr, Jason R. ,  Meng, Fanying ,  Lum, Robert T. ,  Kozlowski, Michael R. ,  Schow, Steven R. ,  Zhichkin, Pavel

IPC分类号： C07F9/24 ,  A61K31/664 ,  A61P35/00

CPC分类号： C07F9/2458 ,  C07F9/2408