摘要:
The present invention relates to novel huperzine A derivatives of formula (II), wherein Y is or R'' and Y together form =CH; R is (C 1 -C 5 ) alkyl, wherein n is 0 or 1, X is H, (C 1 -C 5 ) alkyl; (C 1 -C 5 ) alkyloxy; nitro, halogen, carboxy, alkyloxycarbonyl, hydroxymethyl, hydroxy, amino substituted by bis-(C 1 -C 5 ) alkyl; -(CH 2 ) m COOZ, wherein m=0-5, Z is H or (C 1 -C 5 ) alkyl; -CH=CH-G, wherein G is phenyl, furanyl, carboxy, alkyloxycarbonyl; and dihydro- or tetrahydro-pyridyl substituted by (C 1 -C 5 ) alkyl at the nitrogen atom; R' is H, (C 1 -C 5 ) alkyl, pyridoyl, benzoyl substituted by (C 1 -C 5 ) alkyloxy; R'' is H or (C 1 -C 5 ) alkyl; processes for their use as acetylcholinesterase inhibitor.
摘要:
The object is to contribute to improvement of accuracy and efficiency in evaluation. Provided is a similarity evaluating device for collective data to evaluate similarity between collective data sets in which a plurality of pieces of data are collected. The device includes a patterning part patterning each data of collective data with a selected scale, a matching number extraction part comparing each patterned data in a round-robin to find numbers of matches, and a matching degree determination part finding a degree of matching on the basis of the found numbers of matches with the use of Tanimoto coefficient, thereby evaluating similarity of the collective data simply and quickly.
摘要:
A peak assigning apparatus 1 for assigning peaks of a FP configured by peaks and retention time points of the peaks detected from a chromatogram of a multicomponent material, capable of contributing to improvement of the accuracy and efficiency of evaluation of an evaluation target, includes a peak pattern preparing part 7 preparing a peak pattern for each peak of the target FP and a reference FP that comprises n+1 peaks including n peaks being present on at least one of sides located in front and in the rear of each peak in a time axis direction, and a peak assigning part 9 specifying the peaks corresponding to each other by comparison of the peak patterns.
摘要:
The invention intends to provide a bioassay method using a simple in-vitro test for Daikinchuto, and further to provide a more highly accurate method for quality control of Daikenchuto using the same. These methods are a bioassay method for the pharmacological activity of Daikenchuto, characterized in that a test sample containing Daikenchuto is added to cultured serotonin-producing cells, and the serotonin content in the culture supernatant is subsequently measured; and a quality control method for Daikenchuto preparations in which the pharmacological activity of a test preparation and a reference preparation for which the pharmacological effect as Daikenchuto has been clinically confirmed are evaluated under the same conditions, and the equivalence of the reference preparation and testing preparation is evaluated.
摘要:
Provided are a method for producing a sanshool, which can produce a sanshool in a short process and with high stereoselectivity, as well as a novel diene iron complex compound that is a stable intermediate useful for the production method. The diene iron complex compound is represented by the following general formula (I):
(in which A represents CO, P(R A ) 3 , CN, NO, SO(R A ) 3 , or N(R A ) 2 ; R A represents a straight chain or branched chain alkyl group having 1 to 4 carbon atoms or an aryl group having 6 to 12 carbon atoms; and one of R 1 and R 2 represents a hydrogen atom and the other one thereof represents a structure represented by the following formula (II)):
(in which R represents a hydrogen atom, a hydroxyl group, or a methyl group
摘要翻译:本发明提供一种能够以短立体选择性制造桑拿学校的方法,以及可用于生产方法的稳定中间体的新型二烯铁络合物。 二烯铁络合物由以下通式(I)表示:(其中A表示CO,P(RA)3,CN,NO,SO(RA)3或N(RA)2); RA表示直链 具有1至4个碳原子的直链或支链烷基或具有6至12个碳原子的芳基; R 1和R 2之一表示氢原子,另一个表示由下式(II )):(其中R表示氢原子,羟基或甲基
摘要:
It is an object of the invention to discover a substance that effectively increases the production of adrenomedullin, as well as to provide an adrenomedullin production-enhancing agent utilizing this substance. The adrenomedullin production-enhancing agent is characterized by inclusion of a ginsenoside, a sanshool, and/or a shogaol as active ingredients.