公开(公告)号：EP4365312A2

公开(公告)日：2024-05-08

申请号：EP24162795.9

申请日：2021-04-09

申请人： Takeda Vaccines, Inc.

发明人： DEAN, Hansi ,  KARWAL, Lovkesh ,  LIVENGOOD, Jill A. ,  DAS, Subash ,  BELL, Callum ,  SENA, Johnny ,  DEVITT, Nicholas

IPC分类号： C12Q1/70

CPC分类号： C12Q1/702 ,  C12Q1/6869

摘要： The present invention provides methods for detecting the presence of at least one revertant virus in a sample containing an attenuated virus by single-molecule real-time (SMRT) sequencing. It further provides methods for the quantitative analysis of a mixture of virus haplotypes in a virus sample by SMRT sequencing. It also provides kits useful in performing said methods.

公开(公告)号：EP3299030B1

公开(公告)日：2022-06-08

申请号：EP17199372.8

申请日：2012-07-11

发明人： RICHARDSON, Charles ,  BARGATZE, Robert, F. ,  MENDELMAN, Paul, M.

IPC分类号： A61K39/125

公开(公告)号：EP3717638A1

公开(公告)日：2020-10-07

申请号：EP18883849.4

申请日：2018-11-30

申请人： Takeda Vaccines, Inc.

发明人： LIVENGOOD, Jill A. ,  GIEBLER, Holli ,  DEAN, Hansi ,  SATOU, Tatsuki ,  RAO, Raman ,  MARKS, Jackie ,  LYONS, Mark ,  SHINTANI, Asae ,  GIFFORD, Jamie ,  OGASAWARA, Nao ,  MISAKI, Masafumi ,  ADACHI, Satoshi

IPC分类号： C12N7/06 ,  A61P31/14

公开(公告)号：EP3717511A1

公开(公告)日：2020-10-07

申请号：EP18884352.8

申请日：2018-11-30

申请人： Takeda Vaccines, Inc.

发明人： LIVENGOOD, Jill A. ,  DEAN, Hansi ,  HAN, Htay Htay ,  RAO, Raman ,  MARKS, Jackie ,  DUBIN, Gary ,  DE MOERLOOZE, Laurence ,  PATEL, Hetal

IPC分类号： C07K16/10 ,  C12N7/02

公开(公告)号：EP3703741A1

公开(公告)日：2020-09-09

申请号：EP18815390.2

申请日：2018-11-05

申请人： Takeda Vaccines, Inc.

发明人： LIVENGOOD, Jill A. ,  DEAN, Hansi ,  HAN, Htay Htay ,  RAO, Raman ,  MARKS, Jackie ,  DUBIN, Gary ,  DE MOERLOOZE, Laurence ,  PATEL, Hetal ,  KOMMAREDDY, Sushma

IPC分类号： A61K39/12 ,  A61P31/14

公开(公告)号：EP3052631B1

公开(公告)日：2019-08-07

申请号：EP14850556.3

申请日：2014-10-03

申请人： Takeda Vaccines, Inc.

发明人： HAYNES, Joel

IPC分类号： C12N7/00

公开(公告)号：EP3493839A1

公开(公告)日：2019-06-12

申请号：EP17751959.2

申请日：2017-08-03

申请人： Takeda Vaccines, Inc.

发明人： LIVENGOOD, Jill, Ann ,  STRANGE, Linda, Marie ,  ERB, Steven, Michael

IPC分类号： A61K39/12 ,  A61K39/00

公开(公告)号：EP2968515B1

公开(公告)日：2019-05-08

申请号：EP14717940.2

申请日：2014-03-13

申请人： Takeda Vaccines, Inc.

发明人： STINCHCOMB, Dan T. ,  LIVENGOOD, Jill A. ,  VARGA, Laszlo

IPC分类号： A61K39/12 ,  C12N7/00

公开(公告)号：EP3215621A4

公开(公告)日：2018-06-27

申请号：EP15857562

申请日：2015-11-06

申请人： TAKEDA VACCINES INC

发明人： DAS SUBASH CHANDRA ,  SANTANGELO JOSEPH DAVID ,  STINCHCOMB DAN THOMAS ,  OSORIO JORGE E

IPC分类号： C12N15/41

CPC分类号： A61K39/125 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/575 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/00052 ,  C12N2770/32134 ,  C12N2770/32152 ,  C12N2770/32171 ,  C12N2770/32334 ,  C12N2770/32363 ,  C12N2770/32371 ,  Y02A50/466

摘要： The present disclosure relates to hand, foot, and mouth disease vaccines and immunogenic compositions having one or more antigens from at least one virus that causes hand, foot, and mouth disease in humans, and methods of manufacture, formulation, and testing, and uses thereof. Thus, there is a need to develop vaccines and immunogenic compositions for treating and/or preventing hand, food, and mouth disease, particularly in children. In order to meet this need, the present disclosure provides vaccines and immunogenic compositions for treating and/or preventing hand, foot, and mouth disease that include antigens from at least one virus that causes hand, foot, and mouth disease in humans, such as EV71, CA6, and CA16.

公开(公告)号：EP2324113B8

公开(公告)日：2018-04-04

申请号：EP09805653.4

申请日：2009-08-10

申请人： Takeda Vaccines, Inc.

发明人： RICHARDSON, Charles ,  BARGATZE, Robert ,  HAYNES, Joel ,  STEADMAN, Bryan

IPC分类号： C12N7/01 ,  C07K14/00 ,  C07H21/00 ,  A61K39/12 ,  C07K14/08

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K47/36 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55572 ,  A61K2039/55583 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/16022 ,  C12N2770/16023 ,  C12N2770/16034 ,  Y02A50/467

摘要： The present invention provides polypeptides having a composite amino acid sequence derived from a consensus sequence representing the capsid proteins of two or more circulating strains of a non-enveloped virus. In particular, the invention provides virus-like particles comprising at least one composite polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of a non-enveloped virus and produce an increase in antisera cross-reactivity to one or more circulating strains of the non-enveloped virus. Methods of making composite virus-like particles and vaccine formulations comprising composite virus-like particles are also disclosed.