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    METHOD AND DEVICE FOR IN SITU PROCESS MONITORING
    2.
    发明公开
    METHOD AND DEVICE FOR IN SITU PROCESS MONITORING 审中-公开

    公开(公告)号：EP3650805A1

    公开(公告)日：2020-05-13

    申请号：EP18204888.4

    申请日：2018-11-07

    申请人： Universität Bayreuth

    发明人： Herink, Georg

    IPC分类号： G01B9/02

    摘要： This invention relates to a method and a device for in situ process monitoring and control down to a single pulse measurement during laser processing, like ablation, laser printing additive manufacturing and modification of refractive index. The application relates to laser material processing and to an integrated process monitoring using interference effects of a laser beam or laser pulse.

    Hydrodabcyl
    4.
    发明公开
    Hydrodabcyl 审中-公开

    公开(公告)号：EP3031797A1

    公开(公告)日：2016-06-15

    申请号：EP14197181.2

    申请日：2014-12-10

    申请人： Universität Bayreuth

    发明人： Bombarda, Elisa ,  Kempf, Oxana ,  Kempf, Karl ,  Schobert, Rainer ,  Ullmann, Matthias G.

    IPC分类号： C07C245/08

    CPC分类号： C07C245/08 ,  C09B29/0802 ,  C09B67/0096

    摘要： A new azobenzene-based fluorescence quencher with excellent solubility in aqueous solution is described here. This compound represents an optimized alternative to dabcyl in a variety of biomolecular applications, like fluorogenic protease substrates or nucleic acids probes.

    摘要翻译： 这里描述了一种在水溶液中具有优异溶解度的新型偶氮苯基荧光猝灭剂。 该化合物代表了在各种生物分子应用中的dabcyl的优化替代物，如荧光蛋白酶底物或核酸探针。

    Method for producing a superhydrophobic membrane or surface coating of a substrate
    5.
    发明公开
    Method for producing a superhydrophobic membrane or surface coating of a substrate 有权
    Verfahren zum Herstellen einer超级疏水膜Membran bzw Oberflächenbeschichtungeines Substrats

    公开(公告)号：EP2930265A1

    公开(公告)日：2015-10-14

    申请号：EP14164271.0

    申请日：2014-04-10

    申请人： Universität Bayreuth ,  Philipps Universität Marburg

    发明人： Greiner, Andreas, Prof. Dr. ,  Agarwal, Seema, Prof. Dr. ,  Doimoto, Mitsonobu

    IPC分类号： D06M13/507 ,  D06M13/513 ,  D01D5/00 ,  D01F1/10 ,  D01F6/50

    CPC分类号： C08J3/07 ,  B01D67/0004 ,  B01D67/0009 ,  B01D69/02 ,  B01D2323/08 ,  B01D2323/39 ,  B01D2325/38 ,  C08J2333/16 ,  C08J2429/04 ,  C09D7/65 ,  C09D133/16 ,  D01D5/003 ,  D01F1/10 ,  D01F6/44 ,  D01F6/50 ,  D06M13/507 ,  D06M13/513

    摘要： The invention concerns a method for producing a superhydrophobic membrane or surface coating of a substrate from an aqueous phase comprising the following steps:
    a) Preparing an aqueous dispersion by dispersing particles of hydrophobic polymer(s) in an aqueous solution of protic polymer(s), wherein the protic polymer(s) and the hydrophobic polymer(s) are present in a weight ratio of protic polymer(s) : hydrophobic polymer(s) in a range of 5 : 95 to 22 : 78,
    b) electrospinning the dispersion of step a) onto a carrier for producing the membrane or onto the surface for producing the surface coating thereby producing at least one fiber and a nonwoven fabric from the fiber,
    c) subjecting the nonwoven fabric to a sol-gel process, wherein a precursor/precursors of the sol-gel comprise(s) an alkoxysilane, and
    d) curing the nonwoven fabric obtained by step c) at a temperature in a range of 50°C to 150°C.

    摘要翻译： 本发明涉及从水相制备超疏水膜或表面涂层的方法，包括以下步骤：a）通过将疏水性聚合物的颗粒分散在质子聚合物的水溶液中来制备水分散体， ，其中所述质子聚合物和所述疏水性聚合物以质量聚合物：疏水性聚合物的重量比在5:95至22:78的范围内存在; b）静电纺丝分散体 的步骤a）到用于制造膜的载体上或用于制造表面涂层的表面上，从而从纤维生成至少一种纤维和非织造织物，c）使无纺织物进行溶胶 - 凝胶法，其中前体 溶胶 - 凝胶的前体包含烷氧基硅烷，和d）在50℃至150℃的温度范围内固化由步骤c）得到的无纺织物。

    ESTERASES FOR MONITORING PROTEIN BIOSYNTHESIS IN VITRO
    6.
    发明公开
    ESTERASES FOR MONITORING PROTEIN BIOSYNTHESIS IN VITRO 有权
    酯酶的体外监测蛋白质的生物合成

    公开(公告)号：EP1848815A1

    公开(公告)日：2007-10-31

    申请号：EP06706596.1

    申请日：2006-02-02

    申请人： Universität Bayreuth

    发明人： SPRINZL, Mathias ,  AGAFONOV, Dmitry ,  RABE, Kersten

    IPC分类号： C12Q1/44 ,  G01N33/68

    CPC分类号： C12N15/62 ,  C07H19/167 ,  C07H19/207 ,  C07K16/1203 ,  C12N9/16 ,  C12N9/22 ,  C12Q1/44 ,  G01N33/573

    摘要： The present invention relates to the use of an esterase for monitoring and/or tracking the synthesis of a protein, polypeptide or peptide in a cell-free translation system or in an in vivo expression system in which the synthesis of a protein, polypeptide or peptide can occur, wherein said monitoring and/or tracking comprises the detection of the function of said esterase. The present invention further relates to a vector comprising a nucleic acid molecule coding for an esterase and expressing an esterase fusionprotein. Moreover, the present invention relates to a vector comprising a nucleic acid molecule coding for an esterase and comprising in frame at least one multiple cloning site for a further protein/polypeptide/peptide, to be expressed in form of a fusion protein comprising said esterase (esterase activity) and said further proteinaceous peptide structure. The present invention also provides for a protein, polypeptide or peptide encoded by the vectors of the present invention. Additionally, the present invention relates to a kit comprising a vector of the present invention or a nucleic acid molecule as comprised by the vectors of the present invention. Also disclosed is a method for monitoring and/or tracking the synthesis of a protein, polypeptide or peptide in a cell-free translation system or in an in vivo expression system, comprising the step of detecting the function of an esterase. The present invention also teaches a method for immobilising a protein, polypeptide or peptide comprising the steps of (a) tagging said protein, polypeptide or peptide with an esterase and (b) binding said esterase to an esterase inhibitor, wherein said esterase inhibitor is immobilized on a solid substrate. Moreover, the present invention relates to uses of the vectors of the present invention or the nucleic acid molecules comprised therein for the preparation of a kit or for monitoring and/or tracking the synthesis of a protein, polypeptide or peptide in a cell-free translation system, whereby the monitoring and/or tracking comprises the detection of the function of said esterase.

    A novel biopolymer having excellent tensile strength, extensibility and toughness
    10.
    发明公开
    A novel biopolymer having excellent tensile strength, extensibility and toughness 审中-公开
    Neuartiges Biopolymer mit ausgezeichneter Zugfestigkeit，Dehnbarkeit undZähigkeit

    公开(公告)号：EP2615107A1

    公开(公告)日：2013-07-17

    申请号：EP12151315.4

    申请日：2012-01-16

    申请人： Universität Bayreuth

    发明人： Scheibel, Thomas ,  Bauer, Felix

    IPC分类号： C07K14/435 ,  C12N15/11

    CPC分类号： C07K14/00 ,  A61K38/00 ,  C07K14/43563

    摘要： The present invention relates to a biopolymer comprising or consisting of at least two repeats of an amino acid sequence comprising or consisting of: (a) the amino acid sequence of formula I: Gly- Ser-X 1 - X 2 - Ala- X 3 - Ser- X 4 - X 5 - Ser- X 6 - Ala- X 7 - Ala- X 8 - Lys- X 9 - X 10 - Ala- X 11 - Ala- X 12 -Ser- X 13 - X 14 - Ser-Thr- Ala- X 15 - Ala- Ser- Lys- Gly- Ser- Ala- X 16 - Ala- X 17 - Ser- X 18 - X 19 - Ser- Thr- Ala- X 20 - Ala- X 21 - Lys (formula I), wherein: X 1 is selected from the group consisting of Ala and Ser; X 2 and X 3 are each independently selected from the group consisting of Gly, Ser, Thr and Val; X 4 is selected from the group consisting of Asn, Gly, Gln and Asp; X 5 , X 13 , X 14 , X 18 and X 19 are each independently selected from the group consisting of Gly and Asn; X 6 , X 11 , X 12 , X 15 , X 16 , and X 20 are each independently selected from the group consisting of Gly, Ser, Thr, Ala and Val; X 7 is selected from the group consisting of Ser, Thr and Ala; X 8 and X 21 are each independently selected from the group consisting of Ser and Thr; X 9 is selected from the group consisting of Gly and Asp; X 10 is selected from the group consisting of Ser, Ala and Gly; and X 17 is selected from the group consisting of Ser, Thr, Ala and Val; and wherein at least one of X 4 and X 5 is Gly; at least one of X 13 and X 14 is Gly; and at least one of X 18 and X 19 is Gly; and/or (b) a variant of the amino acid sequence of (a), wherein the variant differs from the amino acid sequence of (a) in 1 to 10 amino acids and wherein the variations are selected from the group consisting of substitutions, deletions, insertions and/or additions and wherein the substitutions do not or do not substantially reduce the biophysical properties of the biopolymer formed as compared to a biopolymer comprising or consisting of repeats of the amino acid sequence of (a), wherein the biophysical properties are at least one of the ability of the biopolymer to stay in solution, the processability of the biopolymer and the tensile strength, extensibility, Young's modulus/stiffness and/or toughness of fibres produced from the biopolymer of the invention. The present invention further relates to a nucleic acid molecule encoding the biopolymer of the invention, a vector comprising the nucleic acid molecule of the invention and a non-human host transformed with the vector of the invention. Furthermore, the present invention relates to methods for producing a biopolymer of the invention and to foams, films, gels, coatings, particles, capsules, springs or nonwoven mats as well as fibres comprising or consisting of the biopolymer of the invention. The present invention also relates to a method of producing fibres and the biopolymer of the invention for use in medicine, agriculture, cosmetics as well as surface, paper, leather and/or textile processing.

    摘要翻译： 本发明涉及包含或由至少两个重复的氨基酸序列组成的生物聚合物，所述氨基酸序列包含或组成：（a）式I的氨基酸序列：Gly-Ser-X 1-X 2 -Ala- X 3 - Ser-X 4 - X 5 - Ser-X 6 - Ala- X 7 - Ala- X 8 - Lys - X 9 - X 10 - Ala- X 11 - Ala- X 12 -Ser -X 13 - X 14 - Ser-Thr-Al-X 15-Al-Ser-Lys-Gly-Ser-Ala- X 16 -Ala- X 17-Ser-X 18-X 19-Ser-Thr-Ala- X 20 -Ala- X 21 - Lys（式I），其中：X 1选自Ala和Ser; X 2和X 3各自独立地选自Gly，Ser，Thr和Val; X 4选自Asn，Gly，Gln和Asp; X 5，X 13，X 14，X 18和X 19各自独立地选自Gly和Asn; X 6，X 11，X 12，X 15，X 16和X 20各自独立地选自Gly，Ser，Thr，Ala和Val; X 7选自Ser，Thr和Ala; X 8和X 21各自独立地选自Ser和Thr; X 9选自Gly和Asp; X 10选自Ser，Ala和Gly; X 17选自Ser，Thr，Ala和Val; 并且其中X 4和X 5中的至少一个是Gly; X 13和X 14中的至少一个是Gly; 并且X 18和X 19中的至少一个是Gly; 和/或（b）（a）的氨基酸序列的变体，其中所述变体与1至10个氨基酸中的（a）的氨基酸序列不同，并且其中所述变体选自取代， 缺失，插入和/或添加，并且其中所述取代不包含或不基本上降低与包含（a）的氨基酸序列的重复序列的生物聚合物相比形成的生物聚合物的生物物理性质，其中生物物理性质是 生物聚合物停留在溶液中的能力中的至少一种，生物聚合物的加工性以及由本发明的生物聚合物生产的纤维的拉伸强度，伸长率，杨氏模量/刚度和/或韧性。 本发明还涉及编码本发明的生物聚合物的核酸分子，包含本发明的核酸分子的载体和用本发明的载体转化的非人宿主。 此外，本发明涉及用于生产本发明的生物聚合物和泡沫，膜，凝胶，涂层，颗粒，胶囊，弹簧或非织造垫的方法以及由本发明的生物聚合物组成或组成的纤维。 本发明还涉及用于医药，农业，化妆品以及表面，纸，皮革和/或纺织品加工的本发明的纤维和生物聚合物的生产方法。