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公开(公告)号：EP2114424B1
公开(公告)日：2021-04-28
申请号：EP08725107.0
申请日：2008-01-31
IPC分类号： A61K36/185 , A61K9/16 , A61K9/19 , A61K31/12 , A23L33/105 , C07H1/08 , C07H17/02 , C07D211/90 , A61P3/06 , A23L2/08 , A23P10/40
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公开(公告)号：EP2457448B1
公开(公告)日：2020-05-06
申请号：EP11191721.7
申请日：2004-11-03
发明人： Miljkovic, Dusan
IPC分类号： A61Q19/00 , A61Q5/02 , A61K8/9789 , A61K36/74
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3.发明公开Coffee cherry cosmetic composition and methods 审中-公开Kosmetische Zusammensetzungen aus Kaffeekirschen und Verfahren
公开(公告)号：EP2457448A3
公开(公告)日：2015-04-15
申请号：EP11191721.7
申请日：2004-11-03
发明人： Miljkovic, Dusan
摘要： A cosmetic composition comprises a coffee cherry preparation, and most preferably an extract from a sub-ripe quick-dried coffee cherry. Particularly contemplated cosmetic compositions are formulated as a shampoo, lotion, cream, balm, or ointment, and will have at least one of an antioxidant effect, an anti-inflammatory effect, a UV-protective effect, an antimutagenic effect, a chemoprotective effect, a scar reducing effect, a skin-lightening effect, a moisturizing effect, a wrinkle reduction effect, and an antibacterial effect.
摘要翻译： 化妆品组合物包含咖啡樱桃制剂，最优选来自亚成熟速干咖啡樱桃的提取物。 特别考虑的化妆品组合物被配制成洗发剂，洗剂，霜剂，香膏或软膏，并且将具有抗氧化作用，抗炎作用，UV-保护作用，抗诱变作用，化学保护作用， 疤痕减轻效果，皮肤发光效果，保湿效果，皱纹减轻效果和抗菌效果。
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公开(公告)号：EP4426283A1
公开(公告)日：2024-09-11
申请号：EP22891065.9
申请日：2022-11-03
IPC分类号： A61K31/225 , A61P3/02 , A61P43/00 , A23L33/10
CPC分类号： A61P43/00 , A61K31/225 , A23L33/10 , A61P3/02
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5.发明公开
公开(公告)号：EP2990058A1
公开(公告)日：2016-03-02
申请号：EP15177703.4
申请日：2015-07-21
发明人： HUNTER, John M.
IPC分类号： A61K47/02 , A61K9/08 , C07H23/00 , A61K31/7024
CPC分类号： A61K9/08 , A61K31/185 , A61K31/7024 , A61K33/06 , A61K47/26 , C07H23/00 , A61K2300/00
摘要： Fructoborate complex containing compositions are presented that have an improved di-complex to boric acid ratio. In some embodiments, compositions are characterized by a di-complex to boric acid ratio of at least 5:1 and more typically at least 10:1 in liquid form, and at least 20:1 in dried form. In other embodiments, compositions are characterized by a minimum content of 80 wt% di-complex and a boric acid content of less than 15 wt%, and more typically less than 5 wt%. Contemplated compositions are thought to have improved biological activity and reduced content of undesired components.
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公开(公告)号：EP2967102A1
公开(公告)日：2016-01-20
申请号：EP14764390.2
申请日：2014-03-14
IPC分类号： A23F5/00
CPC分类号： A61K36/74 , A23L19/01 , A23L33/105 , A61K9/0053 , A61K31/352 , A61K36/185
摘要： Compositions and methods are presented that substantially increase levels of BDNF in blood, and even more pronouncedly exosomal BDNF levels. Suitable compositions include whole coffee fruit extracts and powders or procyanidin-enriched preparations that are orally administered at relatively low dosages. The augmentation of the levels of natural stimulating factor takes place in cerebral circulation.
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公开(公告)号：EP2114424A4
公开(公告)日：2012-07-18
申请号：EP08725107
申请日：2008-01-31
CPC分类号： C07H17/02 , A23L2/08 , A23L33/105 , A23P10/40 , A23V2002/00 , A61K9/1652 , A61K9/19 , A61K31/12 , A61K36/185 , C07D211/90 , C07H1/08 , A23V2200/3262
摘要： Solid, free-flowing, and substantially completely dissolvable preparations with high betalain content are presented. Most typically, the betalain profile of the preparations is near natural and includes betalains in an amount of between 10-40 wt %. As the preparations of the inventive subject matter maintain chemical stability and flowability over extended periods of time, it should be noted that the betalain preparations are now amenable to compounding in small and measured quantities. Furthermore, new biological activities of betalains are shown, and especially include significant induction of SIRT and reduction of serum triglyceride.
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公开(公告)号：EP3738439A1
公开(公告)日：2020-11-18
申请号：EP20168540.1
申请日：2014-03-14
IPC分类号： A23F5/00 , A23L33/105 , A61K36/74
摘要： Compositions and methods are presented that substantially increase levels of BDNF in blood, and even more pronouncedly exosomal BDNF levels. Suitable compositions include whole coffee fruit extracts and powders that are orally administered at relatively low dosages.
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公开(公告)号：EP3210628A1
公开(公告)日：2017-08-30
申请号：EP17152093.5
申请日：2015-07-21
发明人： HUNTER, John M.
IPC分类号： A61K47/02 , A61K47/26 , A61K9/08 , C07H23/00 , A61K31/185 , A61K31/7024 , A61K33/06
CPC分类号： A61K9/08 , A61K31/185 , A61K31/7024 , A61K33/06 , A61K47/26 , C07H23/00 , A61K2300/00
摘要： The present invention relates to a method of increasing di-complex content in a preparative reaction wherein the fructoborate complexes are a mixture of di-complexes and mono complexes, the method comprising: selecting a molar ratio between a fructose and boric acid of about 2:1; contacting the fructose and boric acid in an aqueous solution at the molar ratio to generate a liquid intermediate comprising fructoborate di-complexes and borate; and removing water from the liquid intermediate to generate a dry product comprising fructoborate di-complexes and borate, wherein the ratio of sodium fructoborate di-complexes to borate in the dry product is increased by at least about 13% relative to the ratio of sodium fructoborate di-complexes to borate in the liquid intermediate.
摘要翻译： 本发明涉及在制备反应中增加二元配合物含量的方法，其中果糖硼酸盐配合物是二元配合物和单一配合物的混合物，所述方法包括：选择约2:1的果糖和硼酸之间的摩尔比， 1; 使果糖和硼酸以摩尔比在水溶液中接触以产生包含果糖硼酸二复合物和硼酸盐的液体中间体; 和从液体中间体中除去水以生成包含果糖硼酸二复合物和硼酸盐的干燥产物，其中干燥产物中果糖硼酸二钠与硼酸钠的比例相对于果糖硼酸钠的比例增加至少约13％ 二配合物在液体中间体中硼酸盐化。
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公开(公告)号：EP2967102A4
公开(公告)日：2016-12-21
申请号：EP14764390
申请日：2014-03-14
IPC分类号： A23F5/00 , A23L33/105 , A61K36/74
CPC分类号： A61K36/74 , A23L19/01 , A23L33/105 , A61K9/0053 , A61K31/352 , A61K36/185
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