公开(公告)号：EP4233877A3

公开(公告)日：2023-10-25

申请号：EP23170169.9

申请日：2016-05-27

申请人： VDF Futureceuticals, Inc.

发明人： PIETRZKOWSKI, Zbigniew

IPC分类号： A61K36/185 ,  A61K31/7052 ,  A61K31/7056

摘要： Compositions, methods, and uses are contemplated in which a betalain-containing preparation is administered to a mammal to enhance athletic performance. Most preferably, the preparations are substantially nitrate free and acutely and transiently increase hematocrit, erythropoietin, adrenalin, and beta endorphin, while reducing serum lactate, serum lactate dehydrogenase, heart rate and a rate of perceived exertion.

公开(公告)号：EP3738439A1

公开(公告)日：2020-11-18

申请号：EP20168540.1

申请日：2014-03-14

申请人： VDF Futureceuticals, Inc.

发明人： PIETRZKOWSKI, Zbigniew

IPC分类号： A23F5/00 ,  A23L33/105 ,  A61K36/74

摘要： Compositions and methods are presented that substantially increase levels of BDNF in blood, and even more pronouncedly exosomal BDNF levels. Suitable compositions include whole coffee fruit extracts and powders that are orally administered at relatively low dosages.

公开(公告)号：EP3302512A1

公开(公告)日：2018-04-11

申请号：EP16800834.0

申请日：2016-05-27

申请人： VDF Futureceuticals, Inc.

发明人： PIETRZKOWSKI, Zbigniew

IPC分类号： A61K36/185 ,  A61K31/7052 ,  A61K31/7056

CPC分类号： A61K31/4425 ,  A23L33/105 ,  A23L33/125 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/4858 ,  A61K31/4439 ,  A61K31/706 ,  A61K36/185 ,  A61K36/21 ,  A61K47/26

摘要： Compositions, methods, and uses are contemplated in which a betalain-containing preparation is administered to a mammal to enhance athletic performance. Most preferably, the preparations are substantially nitrate free and acutely and transiently increase hematocrit, erythropoietin, adrenalin, and beta endorphin, while reducing serum lactate, serum lactate dehydrogenase, heart rate and a rate of perceived exertion.

公开(公告)号：EP2367526A1

公开(公告)日：2011-09-28

申请号：EP09760382.3

申请日：2009-11-13

申请人： VDF Futureceuticals, Inc.

发明人： HAMLIN, David ,  MAJETI, Satyanarayana ,  PIETRZKOWSKI, Zbigniew

IPC分类号： A61K9/00 ,  A61K31/353 ,  A61K36/87 ,  A61K36/752

CPC分类号： A61K36/752 ,  A61K9/0056 ,  A61K31/353 ,  A61K36/185 ,  A61K36/45 ,  A61K36/73 ,  A61K36/82 ,  A61K2300/00

摘要： Various compositions and methods are provided to alleviate one or more symptoms associated with hyposalivation or xerostomia. Preferred compositions and methods employ one or more plant extracts and/or a proanthocyanidin at a concentration effective to reduce or eliminate the symptoms. Especially preferred extracts are isolated from a fruit and/or seed (e.g., grape, cranberry, blue berry, black berry, etc.), and where a second extract is present, such extract is preferably isolated from a citrus fruit (e.g., lemon, orange, lime, grapefruit, tangerine, mandarin orange, ugli fruit, etc.).

公开(公告)号：EP4426283A1

公开(公告)日：2024-09-11

申请号：EP22891065.9

申请日：2022-11-03

申请人： VDF Futureceuticals, Inc.

发明人： ANDRYIANAU, Gleb ,  PIETRZKOWSKI, Zbigniew

IPC分类号： A61K31/225 ,  A61P3/02 ,  A61P43/00 ,  A23L33/10

CPC分类号： A61P43/00 ,  A61K31/225 ,  A23L33/10 ,  A61P3/02

公开(公告)号：EP4056043A1

公开(公告)日：2022-09-14

申请号：EP22164560.9

申请日：2014-03-14

申请人： VDF Futureceuticals, Inc.

发明人： PIETRZKOWSKI, Zbigniew

IPC分类号： A23F5/00 ,  A23L33/105 ,  A61K36/74

摘要： Compositions and methods are presented that substantially increase levels of BDNF in blood, and even more pronouncedly exosomal BDNF levels. Suitable compositions include whole coffee fruit extracts and powders that are orally administered at relatively low dosages.

公开(公告)号：EP2967102A1

公开(公告)日：2016-01-20

申请号：EP14764390.2

申请日：2014-03-14

申请人： VDF Futureceuticals, Inc.

发明人： PIETRZKOWSKI, Zbigniew

IPC分类号： A23F5/00

CPC分类号： A61K36/74 ,  A23L19/01 ,  A23L33/105 ,  A61K9/0053 ,  A61K31/352 ,  A61K36/185

摘要： Compositions and methods are presented that substantially increase levels of BDNF in blood, and even more pronouncedly exosomal BDNF levels. Suitable compositions include whole coffee fruit extracts and powders or procyanidin-enriched preparations that are orally administered at relatively low dosages. The augmentation of the levels of natural stimulating factor takes place in cerebral circulation.

公开(公告)号：EP4233877A2

公开(公告)日：2023-08-30

申请号：EP23170169.9

申请日：2016-05-27

申请人： VDF Futureceuticals, Inc.

发明人： PIETRZKOWSKI, Zbigniew

IPC分类号： A61K31/7056

摘要： Compositions, methods, and uses are contemplated in which a betalain-containing preparation is administered to a mammal to enhance athletic performance. Most preferably, the preparations are substantially nitrate free and acutely and transiently increase hematocrit, erythropoietin, adrenalin, and beta endorphin, while reducing serum lactate, serum lactate dehydrogenase, heart rate and a rate of perceived exertion.

公开(公告)号：EP2114424A1

公开(公告)日：2009-11-11

申请号：EP08725107.0

申请日：2008-01-31

申请人： VDF Futureceuticals, Inc.

发明人： PIETRZKOWSKI, Zbigniew ,  THRESHER, Wayne, Carl

IPC分类号： A61K36/00

CPC分类号： C07H17/02 ,  A23L2/08 ,  A23L33/105 ,  A23P10/40 ,  A23V2002/00 ,  A61K9/1652 ,  A61K9/19 ,  A61K31/12 ,  A61K36/185 ,  C07D211/90 ,  C07H1/08 ,  A23V2200/3262

摘要： Solid, free-flowing, and substantially completely dissolvable preparations with high betalain content are presented. Most typically, the betalain profile of the preparations is near natural and includes betalains in an amount of between 10-40 wt%. As the preparations of the inventive subject matter maintain chemical stability and flowability over extended periods of time, it should be noted that the betalain preparations are now amenable to compounding in small and measured quantities. Furthermore, new biological activities of betalains are shown, and especially include significant induction of SIRT and reduction of serum triglyceride.

摘要翻译： 介绍了具有高甜菜素含量的固体，自由流动和基本完全可溶解的制剂。 最典型地，制剂的甜菜素分布接近自然并且包括10-40重量％之间的甜菜碱。 由于本发明主题的制剂在很长一段时间内保持化学稳定性和流动性，应该注意的是，甜菜碱制剂现在适合以小的和测量的量混合。 此外，还展示了甜菜素的新生物活性，尤其包括显着诱导SIRT和降低血清甘油三酯。