LOTION
    4.
    发明授权
    LOTION 失效
    洗剂

    公开(公告)号:EP0753297B1

    公开(公告)日:2002-09-25

    申请号:EP94916418.0

    申请日:1994-05-30

    摘要: A lotion comprising a tricyclic compound represented by 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone or a pharmaceutically acceptable salt thereof, a dissolution/absorption promoter, a liquid medium, and optionally an emulsifying agent or a mixture thereof with a thickening agent. The lotion is stable and excellent in absorbability, scarcely irritates the skin, and can be sustainedly released. It is useful for treating and preventing inflammatory and proliferative dermatoses and immunologically mediated skin diseases.

    摘要翻译: 含有以17-烯丙基-1,14-二羟基-12- [2-(4-羟基-3-甲氧基环己基)-1-甲基乙烯基] -23,25-二甲氧基-13,19,21为代表的三环化合物的洗剂, 27-四甲基-11,28-二氧杂-4-氮杂三环[22.3.1.0 4,9]二十八碳-18-烯-2,3,10,16-四酮或其药学上可接受的盐,溶解/吸收促进剂,液体 介质和任选的乳化剂或其与​​增稠剂的混合物。 该乳液稳定且具有优异的吸收性,几乎不刺激皮肤,并且可以持续释放。 它可用于治疗和预防炎症和增殖性皮肤病以及免疫介导的皮肤疾病。