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    IMMUNE REPERTOIRE MONITORING
    2.
    发明公开
    IMMUNE REPERTOIRE MONITORING 审中-公开

    公开(公告)号：EP4286531A3

    公开(公告)日：2024-01-17

    申请号：EP23187659.0

    申请日：2019-03-22

    申请人： Life Technologies Corporation

    发明人： Looney, Timothy

    IPC分类号： C12Q1/6886 ,  C12Q1/6806

    摘要： The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, methods provide for determining convergence of T cell receptor and/or B cell receptor repertoires in samples prior to a treatment and predicting a subject's response to the treatment based on the measured convergence frequency. In another aspect, methods provide for an immune receptor haplotype group and predicting a subject's potential or predisposition to be protected from or vulnerable to an adverse event following a treatment.

    POLYMERASE COMPOSITIONS, METHODS OF MAKING AND USING SAME
    7.
    发明公开
    POLYMERASE COMPOSITIONS, METHODS OF MAKING AND USING SAME 审中-公开

    公开(公告)号：EP4219739A2

    公开(公告)日：2023-08-02

    申请号：EP22208638.1

    申请日：2014-09-30

    申请人： Life Technologies Corporation

    发明人： VANDER HORN, Peter ,  MAZUR, Daniel ,  NIKIFOROV, Theo ,  LANDES, Mindy ,  TOZER, Eileen

    IPC分类号： C12Q1/68 ,  C12N9/12

    摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, modified polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides modified polymerases having lower systematic error as compared to a reference polymerase. In one aspect, the disclosure relates to modified polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In some aspects, the disclosure relates to modified polymerases useful for the generation of nucleic acid libraries or nucleic acid templates. In some aspects, the disclosure relates to the identification of homologous amino acid mutations that can be transferred across classes or families of polymerases to provide novel polymerases with altered properties.

    POLYMERASE COMPOSITIONS AND KITS, AND METHODS OF USING AND MAKING THE SAME
    10.
    发明公开
    POLYMERASE COMPOSITIONS AND KITS, AND METHODS OF USING AND MAKING THE SAME 审中-公开

    公开(公告)号：EP4141126A1

    公开(公告)日：2023-03-01

    申请号：EP22185494.6

    申请日：2016-09-27

    申请人： Life Technologies Corporation

    发明人： MAZUR, Daniel ,  VANDER HORN, Peter ,  TOZER, Eileen ,  CHEN, Sihong ,  LUO, Guobin ,  SHIRLEY, Joshua ,  HEINEMANN, Kevin

    IPC分类号： C12Q1/68 ,  C12N9/12

    摘要： The present disclosure provides compositions, methods, kits, systems and apparatus that are useful for nucleic acid polymerization. In particular, recombinant polymerases and biologically active fragments thereof are provided that allow for nucleic acid amplification. In some aspects, the disclosure provides recombinant polymerases that yield lower systematic error rates and/or improved accuracy, when used in sequencing by synthesis reactions as compared to a control polymerase. In one aspect, the disclosure relates to recombinant polymerases useful for nucleic acid sequencing, genotyping, copy number variation analysis, paired-end sequencing and other forms of genetic analysis. In another aspect, the recombinant polymerases are useful for the amplification of nucleic acid templates during PCR, emPCR, isothermal amplification, recombinase polymerase amplification, rolling circle amplification, strand displacement amplification and proximity ligation amplification. In some aspects, the disclosure relates to recombinant polymerases useful for the generation of nucleic acid libraries and/or nucleic acid templates.