公开(公告)号：EP1863859A4

公开(公告)日：2009-04-22

申请号：EP06739903

申请日：2006-03-28

申请人： AP PHARMA INC

发明人： HELLER JORGE ,  SCHACHT ETIENNE ,  TONCHEVA VESKA

IPC分类号： C08F297/02 ,  A61K9/00 ,  A61K47/00 ,  C08F261/00 ,  C08F263/00 ,  C08F283/06 ,  C08F287/00 ,  C08L51/00

CPC分类号： A61K9/0048 ,  A61K9/0024 ,  A61K47/34 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6903 ,  C08F261/00 ,  C08F263/00 ,  C08F283/06 ,  C08F287/00 ,  C08L51/003 ,  C08L51/006 ,  C08L59/00 ,  C08L2666/02

公开(公告)号：EP1865988A2

公开(公告)日：2007-12-19

申请号：EP06748831.2

申请日：2006-03-28

申请人： AP Pharma, Inc.

发明人： HELLER, Jorge ,  SCHACHT, Etienne ,  TONCHEVA, Veska

IPC分类号： A61K47/00

CPC分类号： C08G63/664 ,  A61K9/4866 ,  A61K38/00 ,  A61K47/34 ,  A61K47/60 ,  A61L27/18 ,  C08L59/00 ,  C08L71/02 ,  C08L2203/02

摘要： This invention relates to block copolymer delivery vehicles comprising a polyethyleneglycol-polyacetal, and to controlled release pharmaceutical compositions comprising the delivery vehicle and an active agent. The block copolymers of the invention may be thermogel block copolymers. The pharmaceutical compositions may be in the form of a topical, syringable, or injectable formulation for local controlled delivery of the active agent.

公开(公告)号：EP1863859A2

公开(公告)日：2007-12-12

申请号：EP06739903.0

申请日：2006-03-28

申请人： AP Pharma, Inc.

发明人： HELLER, Jorge ,  SCHACHT, Etienne ,  TONCHEVA, Veska

IPC分类号： C08F297/02

CPC分类号： A61K9/0048 ,  A61K9/0024 ,  A61K47/34 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6903 ,  C08F261/00 ,  C08F263/00 ,  C08F283/06 ,  C08F287/00 ,  C08L51/003 ,  C08L51/006 ,  C08L59/00 ,  C08L2666/02

摘要： The present invention provides graft copolymer delivery vehicle which comprises a polyethyleneglycol (PEG)-polyacetal (PA) copolymer or a polyethyleneglycol (PEG)-polyacetal (PA)-polyorthoester (POE) copolymer. The polyethyleneglycol-polyacetal graft copolymers or the polyethyleneglycol-polyacetal-polyorthoester graft copolymers, in particular, the PA-g-PEG or the PA-POE-g-PEG suitable for the invention are represented by Formulae (I) and (V).

公开(公告)号：EP1796629A2

公开(公告)日：2007-06-20

申请号：EP05802951.3

申请日：2005-09-27

申请人： AP Pharma, Inc.

发明人： NG, Steven, Y. ,  SHEN, Hui-Rong ,  HELLER, Jorge

IPC分类号： A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10

CPC分类号： A61K47/34 ,  A61K8/85 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/439 ,  A61K31/445 ,  A61K31/573 ,  A61K31/765 ,  A61K45/06 ,  A61K47/10 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00

摘要： A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringeable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.

公开(公告)号：EP1315777A2

公开(公告)日：2003-06-04

申请号：EP01968589.0

申请日：2001-09-06

申请人： AP Pharma, Inc.

发明人： BROCCHINI, Stephen ,  HELLER, Jorge ,  TOMLINSON, Ryan ,  DUNCAN, Ruth ,  GARRETT, Shane ,  KLEE, Marcus

IPC分类号： C08L59/00 ,  A61K47/48 ,  A61K51/06 ,  C08G4/00

CPC分类号： C08G2/30 ,  A61K47/59 ,  A61K47/60 ,  A61K47/61 ,  A61K47/645 ,  C08G4/00 ,  C08L59/00

摘要： Degradable polyacetal polymers and functionalized degradable polyacetal polymers have properties favorable for use in pharmaceutical and biomedical applications. The degradable polyacetal polymers are relatively stable at physiological pH with favorable biodistribution profiles, and degrade readily in low pH conditions. Conjugates of the polymers with drugs, especially anticancer drugs, and use for treatment of cancer.

公开(公告)号：EP1448666B1

公开(公告)日：2008-09-10

申请号：EP02789694.3

申请日：2002-11-15

申请人： AP Pharma, Inc.

发明人： NG, Steven, Y. ,  HELLER, Jorge

IPC分类号： C08G65/34 ,  C08G65/00 ,  C08G63/664 ,  A61K47/00

CPC分类号： C08G63/668 ,  C08G65/002 ,  C08G65/34 ,  C08G2650/42 ,  Y10S514/816 ,  Y10S514/817 ,  Y10S514/887

摘要： Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents contain amine functionalities and α-hydroxy acid-containing groups. Block copolymers contain these bioerodible poly (ortho esters). These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encpasulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.

公开(公告)号：EP1084170B1

公开(公告)日：2007-01-17

申请号：EP99926034.2

申请日：1999-05-28

申请人： AP Pharma, Inc.

发明人： HELLER, Jorge ,  NG, Steven, Y.

IPC分类号： C08G63/664 ,  C08L71/02 ,  A61K9/51 ,  A61K9/20

CPC分类号： A61K9/1075 ,  A61K9/204 ,  C08G63/664 ,  C08L71/02 ,  C08L2666/14

摘要： PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents, especially when the POE block(s) contain at least one unit containing an α-hydroxy acid.

公开(公告)号：EP1796629A4

公开(公告)日：2013-01-09

申请号：EP05802951

申请日：2005-09-27

申请人： AP PHARMA INC

发明人： NG STEVEN Y ,  SHEN HUI-RONG ,  HELLER JORGE

IPC分类号： A61K9/00 ,  A61K8/85 ,  A61K8/86 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K9/16 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00

CPC分类号： A61K47/34 ,  A61K8/85 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/439 ,  A61K31/445 ,  A61K31/573 ,  A61K31/765 ,  A61K45/06 ,  A61K47/10 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00

摘要： A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical composition may be a topical, syringeable, or injectable formulation; and is suitable for local delivery of the active agent. Methods of treatment are also disclosed.

公开(公告)号：EP1280558B1

公开(公告)日：2005-12-07

申请号：EP01935418.2

申请日：2001-05-11

申请人： AP Pharma, Inc.

发明人： NG, Steven, Y. ,  SHEN, Hui-Rong ,  HELLER, Jorge

IPC分类号： A61K47/34

CPC分类号： A61K47/34

公开(公告)号：EP1448666A1

公开(公告)日：2004-08-25

申请号：EP02789694.3

申请日：2002-11-15

申请人： AP Pharma, Inc.

发明人： NG, Steven, Y. ,  HELLER, Jorge

IPC分类号： C08G65/34 ,  C08G65/00 ,  C08G63/664 ,  A61K47/00

CPC分类号： C08G63/668 ,  C08G65/002 ,  C08G65/34 ,  C08G2650/42 ,  Y10S514/816 ,  Y10S514/817 ,  Y10S514/887

摘要： Bioerodible poly(ortho esters) useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents contain amine functionalities and α-hydroxy acid-containing groups. Block copolymers contain these bioerodible poly (ortho esters). These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encpasulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.