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1.发明公开PEG-POLYACETAL DIBLOCK AND TRIBLOCK COPOLYMERS AND PHARMACEUTICAL COMPOSITIONS 审中-公开PEG聚缩醛二嵌段和三嵌段共聚物和药物组合物
公开(公告)号：EP1865988A2
公开(公告)日：2007-12-19
申请号：EP06748831.2
申请日：2006-03-28
申请人： AP Pharma, Inc.
发明人： HELLER, Jorge , SCHACHT, Etienne , TONCHEVA, Veska
IPC分类号： A61K47/00
CPC分类号： C08G63/664 , A61K9/4866 , A61K38/00 , A61K47/34 , A61K47/60 , A61L27/18 , C08L59/00 , C08L71/02 , C08L2203/02
摘要： This invention relates to block copolymer delivery vehicles comprising a polyethyleneglycol-polyacetal, and to controlled release pharmaceutical compositions comprising the delivery vehicle and an active agent. The block copolymers of the invention may be thermogel block copolymers. The pharmaceutical compositions may be in the form of a topical, syringable, or injectable formulation for local controlled delivery of the active agent.
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2.发明公开PEG-POLYACETAL AND PEG-POLYACETAL-POE GRAFT COPOLYMERS AND PHARMACEUTICAL COMPOSITIONS 审中-公开PEG-聚缩醛及聚缩醛PEG POE接枝共聚物和药物组合物
公开(公告)号：EP1863859A2
公开(公告)日：2007-12-12
申请号：EP06739903.0
申请日：2006-03-28
申请人： AP Pharma, Inc.
发明人： HELLER, Jorge , SCHACHT, Etienne , TONCHEVA, Veska
IPC分类号： C08F297/02
CPC分类号： A61K9/0048 , A61K9/0024 , A61K47/34 , A61K47/59 , A61K47/60 , A61K47/6903 , C08F261/00 , C08F263/00 , C08F283/06 , C08F287/00 , C08L51/003 , C08L51/006 , C08L59/00 , C08L2666/02
摘要： The present invention provides graft copolymer delivery vehicle which comprises a polyethyleneglycol (PEG)-polyacetal (PA) copolymer or a polyethyleneglycol (PEG)-polyacetal (PA)-polyorthoester (POE) copolymer. The polyethyleneglycol-polyacetal graft copolymers or the polyethyleneglycol-polyacetal-polyorthoester graft copolymers, in particular, the PA-g-PEG or the PA-POE-g-PEG suitable for the invention are represented by Formulae (I) and (V).
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