公开(公告)号：EP2623105A2

公开(公告)日：2013-08-07

申请号：EP13155606.0

申请日：2005-01-18

申请人： Alt Solutions, Inc.

发明人： Bondarev, Igor, E. ,  Bertram, John, S.

IPC分类号： A61K31/7072 ,  A61P35/00 ,  A61K31/7068 ,  A01N61/00 ,  G01N33/50 ,  G01N33/573 ,  G01N33/574 ,  A61K31/513 ,  A61K31/522 ,  C12N15/113

CPC分类号： C12N15/1137 ,  A61K31/513 ,  A61K31/522 ,  A61K31/7068 ,  A61K31/7072 ,  C12N2310/11 ,  C12N2310/111 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y207/07049 ,  G01N33/5011 ,  G01N33/5038 ,  G01N33/57407 ,  G01N33/5748 ,  G01N2333/9128 ,  G01N2500/10

摘要： A reverse transcriptase encoded by L-1 (LINE-1) has been identified as a target molecule for treating or preventing cancers induced or mediated by this molecule. Method of treating or preventing such cancers in patients involves administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptase in cells of the patients. The inhibitor or antagonist blocks lengthening of telomeres in telomerase negative cells. Methods and kits for detecting pathologically proliferating cells expressing L1RT are also disclosed.

摘要翻译： 由L-1（LINE-1）编码的逆转录酶已被鉴定为用于治疗或预防由该分子诱导或介导的癌症的靶分子。 在患者的细胞中治疗或预防这种癌症的方法包括给予治疗有效量的具有逆转录酶抑制剂或拮抗剂的组合物。 抑制剂或拮抗剂阻断端粒酶阴性细胞延长端粒。 还公开了用于检测表达L1RT的病理性增殖细胞的方法和试剂盒。

公开(公告)号：EP2001488A4

公开(公告)日：2009-11-25

申请号：EP07753185

申请日：2007-03-14

申请人： ALT SOLUTIONS INC

发明人： BONDAREV IGOR E

IPC分类号： A61K31/7068 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61P35/00 ,  C07D239/47 ,  C07D239/54 ,  C07D473/28 ,  C07D473/34

CPC分类号： A61K31/7072 ,  A61K31/52 ,  A61K45/06 ,  C07D239/54 ,  C07D405/06 ,  C07D473/34 ,  A61K2300/00

公开(公告)号：EP2623105A3

公开(公告)日：2013-10-09

申请号：EP13155606.0

申请日：2005-01-18

申请人： Alt Solutions, Inc.

发明人： Bondarev, Igor, E. ,  Bertram, John, S.

IPC分类号： A61K31/7072 ,  A61P35/00 ,  A61K31/7068 ,  G01N33/50 ,  G01N33/573 ,  G01N33/574 ,  A61K31/513 ,  A61K31/522 ,  C12N15/113

CPC分类号： C12N15/1137 ,  A61K31/513 ,  A61K31/522 ,  A61K31/7068 ,  A61K31/7072 ,  C12N2310/11 ,  C12N2310/111 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y207/07049 ,  G01N33/5011 ,  G01N33/5038 ,  G01N33/57407 ,  G01N33/5748 ,  G01N2333/9128 ,  G01N2500/10

摘要： A reverse transcriptase encoded by L-1 (LINE-1) has been identified as a target molecule for treating or preventing cancers induced or mediated by this molecule. Method of treating or preventing such cancers in patients involves administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptase in cells of the patients. The inhibitor or antagonist blocks lengthening of telomeres in telomerase negative cells. Methods and kits for detecting pathologically proliferating cells expressing L1RT are also disclosed.

公开(公告)号：EP1868615A4

公开(公告)日：2012-06-27

申请号：EP06748718

申请日：2006-03-27

申请人： ALT SOLUTIONS INC

发明人： BONDAREV IGOR E

IPC分类号： A61K31/685 ,  A61P35/00

CPC分类号： A61K49/0008 ,  A61K31/675 ,  A61K31/7072 ,  A61K31/7076 ,  A61K2300/00

公开(公告)号：EP1713337A4

公开(公告)日：2010-09-15

申请号：EP05711492

申请日：2005-01-18

申请人： ALT SOLUTIONS INC

发明人： BONDAREV IGOR E ,  BERTRAM JOHN S

IPC分类号： A61K31/7072 ,  A01N61/00 ,  A61K31/513 ,  A61K31/522 ,  A61K31/7068 ,  A61K48/00 ,  A61P35/00 ,  C12N15/113

CPC分类号： C12N15/1137 ,  A61K31/513 ,  A61K31/522 ,  A61K31/7068 ,  A61K31/7072 ,  C12N2310/11 ,  C12N2310/111 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y207/07049 ,  G01N33/5011 ,  G01N33/5038 ,  G01N33/57407 ,  G01N33/5748 ,  G01N2333/9128 ,  G01N2500/10

公开(公告)号：EP1885370A2

公开(公告)日：2008-02-13

申请号：EP06770683.8

申请日：2006-05-18

申请人： Alt Solutions, Inc.

发明人： BONDAREV, Igor, E.

IPC分类号： A61K31/522

CPC分类号： A61K31/522 ,  A61K9/0019 ,  A61K9/0095 ,  A61K45/06 ,  A61N5/10

摘要： Acyclic nucleoside analogs such as acyclovir, ganciclovir, penciclovir and the corresponding pro-drugs, i.e., valacyclovir, valganciclovir and famciclovir, respectively have been identified as inhibitors or antagonists of both telomerase (encoded by TERT) and reverse transcriptase encoded by L-1 (LINE-1) RT, and as useful for treating or preventing cancers induced or mediated by the two enzymes. Method of treating or preventing such cancers in patients involves administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases in cells of the patients. The inhibitor or antagonist blocks lengthening of telomeres in telomerase positive and telomerase negative cells. Methods and kits for detecting pathologically proliferating cells expressing TERT and L1RT are also disclosed.

公开(公告)号：EP1885370A4

公开(公告)日：2012-07-25

申请号：EP06770683

申请日：2006-05-18

申请人： ALT SOLUTIONS INC

发明人： BONDAREV IGOR E

IPC分类号： A61K31/54 ,  A61K9/14 ,  A61K31/38 ,  A61K31/47 ,  A61K31/50

CPC分类号： A61K31/522 ,  A61K9/0019 ,  A61K9/0095 ,  A61K45/06 ,  A61N5/10

公开(公告)号：EP1868615A2

公开(公告)日：2007-12-26

申请号：EP06748718.1

申请日：2006-03-27

申请人： Alt Solutions, Inc.

发明人： BONDAREV, Igor, E.

IPC分类号： A61K31/675

CPC分类号： A61K49/0008 ,  A61K31/675 ,  A61K31/7072 ,  A61K31/7076 ,  A61K2300/00

摘要： Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention of tumorigenic telomerase positive cells from having a chance to grow into a tumor and methods for promoting tumor regression (decrease in size of an established tumor) using acyclic nucleoside analogs has been disclosed.

公开(公告)号：EP1713337A2

公开(公告)日：2006-10-25

申请号：EP05711492.8

申请日：2005-01-18

申请人： Alt Solutions, Inc.

发明人： BONDAREV, Igor, E. ,  BERTRAM, John, S.

IPC分类号： A01N61/00

CPC分类号： C12N15/1137 ,  A61K31/513 ,  A61K31/522 ,  A61K31/7068 ,  A61K31/7072 ,  C12N2310/11 ,  C12N2310/111 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y207/07049 ,  G01N33/5011 ,  G01N33/5038 ,  G01N33/57407 ,  G01N33/5748 ,  G01N2333/9128 ,  G01N2500/10

摘要： A reverse transcriptase encoded by L-1 (LINE-1) has been identified as a target molecule for treating or preventing cancers induced or mediated by this molecule. Method of treating or preventing such cancers in patients involves administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptase in cells of the patients. The inhibitor or antagonist blocks lengthening of telomeres in telomerase negative cells. Methods and kits for detecting pathologically proliferating cells expressing L1RT are also disclosed.

公开(公告)号：EP2001488A2

公开(公告)日：2008-12-17

申请号：EP07753185.3

申请日：2007-03-14

申请人： Alt Solutions, Inc.

发明人： BONDAREV, Igor, E.

IPC分类号： A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/52 ,  A61K31/522 ,  A61K31/505 ,  C07D473/28 ,  C07D473/34 ,  C07D239/47 ,  C07D239/54 ,  C07H19/067 ,  C07H19/073 ,  C07H19/167 ,  C07H19/173

CPC分类号： A61K31/7072 ,  A61K31/52 ,  A61K45/06 ,  C07D239/54 ,  C07D405/06 ,  C07D473/34 ,  A61K2300/00

摘要： Nucleoside chemical compounds, which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) are disclosed. The compounds interfere with the activities of telomerase and reverse transcriptase, and are useful as antivirals, antibacterials and anticancer agents. Methods of treating or preventing cancers in patients involving administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases (RTs) expressed in cells of the patients are also disclosed. Method of using nucleoside analogs and other inhibitors of RTs in conjunction with DNA damaging agents such as genotoxic agents or radiation or photodynamic therapy or combinations these for the treatment of various cancers are also disclosed.