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22 条记录 (耗时 0.012 秒)

    ANTIOBESITY COMPOSITION
    2.
    发明公开
    ANTIOBESITY COMPOSITION 有权
    组成对抗肥胖

    公开(公告)号：EP1951275A1

    公开(公告)日：2008-08-06

    申请号：EP06799129.9

    申请日：2006-10-09

    申请人： ANGIOLAB., INC. ,  Kim, Min-Young

    发明人： KIM, Min-Young ,  LEE, Hee-Suk ,  KIM, Joon-Sik ,  HAHM, Jong-Cheon

    IPC分类号： A61K36/53 ,  A61K36/282 ,  A61K36/605 ,  A23L1/29 ,  A61P3/04

    CPC分类号： A61K36/82 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/258 ,  A61K36/282 ,  A61K36/53 ,  A61K36/605 ,  A61K36/68 ,  A61K2300/00 ,  A23V2250/21 ,  A23V2250/5114 ,  A23V2250/5066

    摘要： The present invention provides antiobesity composition comprising extract of Melissa as an active ingredient, use of Melissa extract, and a method for suppressing obesity using the composition. Also, the present invention provides an antiobesity composition comprising extract of Melissa and extract of Mori Folium as active ingredients, use of a mixture of Melissa extract and Mori Folium extract, and a method for suppressing obesity using the composition. Further, the present invention provides an antiobesity composition comprising extract of Melissa, extract of Artemisia and extract of Mori Folium as active ingredients, use of a mixture of Melissa extract, Artemisia extract and Mori Folium extract, and a method for suppressing obesity using the composition. When the present compositions are administrated into genetically obese mice or high fat diet-induced obese mice, the present compositions reduced body weight, body fat and gonadal fat, and reduce blood cholesterol level and obesity-related blood glucose level. Also, the present compositions suppress hypertrophy of adipocytes, and inhibit the accumulation of lipid in the liver by reducing the size and number of lipid vacuoles. Furthermore, in human clinial trial the present compositions show that body weight, PIBW, body fat, especially visceral fat, apolipoprotin B concentration, ratio of total cholesterol/HDL cholesterol and ratio of LDL cholesterol /HDL cholesterol are significantly decreased, and atherogenic index is improved and muscle mass is increased. Thus, the present compositions can be usefully applied as antiobesity composition for reduction of body weight and suppression of abdominal fat, particularly, visceral fat.

    USE OF PAEONOL FOR INHIBITING ANGIOGENESIS OR FOR ENHANCING RADIOSENSITIZATION
    5.
    发明公开
    USE OF PAEONOL FOR INHIBITING ANGIOGENESIS OR FOR ENHANCING RADIOSENSITIZATION 有权
    丹皮酚抑制血管发生或改善RADIO意识USE

    公开(公告)号：EP1877043A1

    公开(公告)日：2008-01-16

    申请号：EP06757650.4

    申请日：2006-05-04

    申请人： ANGIOLAB., INC.

    发明人： KIM, Min-Young ,  LEE, Hee-Suk ,  BAE, Ki-Hwan ,  YUN, Yeon-Sook ,  SONG, Jie-Young ,  HAN, Young-Soo

    IPC分类号： A61K31/05 ,  A61P35/04 ,  A61P43/00

    CPC分类号： A61K31/05

    摘要： The present invention relates to a composition comprising paeonol of formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient for inhibiting angiogenesis, or for enhancing radiosensitization. The present invention also relates to novel use of paeonol of formula (I) or a pharmaceutically acceptable salt thereof for the manufacture of a composition for inhibiting angiogenesis, or for the manufacture of a composition for enhancing radiosensitization. Also, the present invention relates to a method for inhibiting angiogenesis which comprises administrating to a subject in need thereof an effective amount of paeonol of formula (I) or a pharmaceutically acceptable salt thereof, or a method for enhancing radiosensitization which comprises administrating an effective amount of paeonol of formula (I) or pharmaceutically acceptable salts thereof to a subject in need of radiotherapy.