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    FRACTION OF MELISSA LEAF EXTRACT HAVING ANGIOGENESIS AND MMP INHIBITORY ACTIVITIES, AND COMPOSITION COMPRISING THE SAME
    8.
    发明公开
    FRACTION OF MELISSA LEAF EXTRACT HAVING ANGIOGENESIS AND MMP INHIBITORY ACTIVITIES, AND COMPOSITION COMPRISING THE SAME 有权
    具有血管生成和MMP抑制活性的薄荷叶提取物的组分及包含该组合物的组合物

    公开(公告)号：EP2178545A2

    公开(公告)日：2010-04-28

    申请号：EP08793448.5

    申请日：2008-08-25

    申请人： Angiolab, Inc. ,  Kim, Min-Young

    发明人： KIM, Min Young ,  HAHM, Jong Cheon ,  PARK, Byung Young ,  PARK, Eun Kyu ,  LEE, Hee Suk

    IPC分类号： A61K36/53

    CPC分类号： A61K36/53

    摘要： The present invention relates to an ethyl acetate fraction of Melissa leaf having excellent an- giogenesis and MMP inhibitory activities, and a composition comprising the same. In particular, the ethyl acetate fraction of Melissa leaf is characterized that Melissa leaf is extracted with 50-100% C1-C6 alcohol, and concentrated, and then the concentrated alcohol extract is suspended in water, and fractionated with ethyl acetate, and dried to obtain the ethyl acetate fraction of Melissa leaf. The ethyl acetate fraction of Melissa leaf of the present invention has strong and excellent anti- angiogenic and MMP inhibitory activities. Therefore, the composition comprising the ethyl acetate fraction of Melissa leaf of the present invention can be used as an agent for the treatment or prevention of angiogenesis -related diseases and MMP-mediated diseases.

    摘要翻译： 本发明涉及具有优异的抗氧化作用和MMP抑制活性的梅利莎叶乙酸乙酯部分，以及包含其的组合物。 特别地，梅利莎叶的乙酸乙酯部分的特征在于，用50-100％的C1-C6醇提取梅利莎叶并浓缩，然后将浓缩的醇提取物悬浮于水中，并用乙酸乙酯分级，并干燥至 得到梅利莎叶的乙酸乙酯部分。 本发明的梅利莎叶的乙酸乙酯部分具有强的和优异的抗血管生成和MMP抑制活性。 因此，包含本发明的香蜂草叶的乙酸乙酯部分的组合物可以用作治疗或预防血管生成相关疾病和MMP介导的疾病的药剂。