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1.发明公开ANTI-DOG IGE MONOCLONAL ANTIBODY, AND LIGHT-CHAIN VARIABLE REGION AND HEAVY-CHAIN VARIABLE REGION OF ANTI-DOG IGE MONOCLONAL ANTIBODY 审中-公开单克隆抗体狗和IGE轻链可变区和重链可变区单克隆抗体的狗的IgE
公开(公告)号：EP2977387A4
公开(公告)日：2017-03-29
申请号：EP14769566
申请日：2014-03-17
发明人： OHARA OSAMU , NAGASE TAKAHIRO , YAMAGUCHI YOSHIHIRO , OHARA REIKO , MASUDA KENICHI , TSUKUI TOSHIHIRO
CPC分类号： C07K16/4291 , A01K2217/052 , A01K2227/706 , A01K2267/01 , C07K2317/14 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2319/21 , C12N15/8509 , C12N2015/8518 , G01N33/577 , G01N33/6854
摘要： Problem to be Solved: The present invention is intended to provide a polynucleotide encoding the light-chain variable region and the heavy-chain variable region of an anti-dog IgE antibody; and an anti-dog IgE antibody containing these variable regions. Solution: The present invention is DNA encoding a heavy-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 2 or 6 and DNA encoding a light-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 4 or 8, and an anti-dog IgE monoclonal antibody which binds to dog IgE, containing these variable regions or a functional fragment thereof which binds to dog IgE.
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2.发明公开
公开(公告)号：EP4155315A1
公开(公告)日：2023-03-29
申请号：EP21808352.5
申请日：2021-05-21
发明人： MASUDA Kenichi , SAITO Takashi
IPC分类号： C07K14/165 , A61K31/7032 , A61K38/04 , A61K38/16 , A61K39/215 , A61P31/14 , A61P37/04 , C07H15/04 , C07K7/06 , C07K7/08
摘要： The present invention provides a vaccine against a coronavirus. According to the present invention, there is provided a peptide consisting of the amino acid sequence set forth in SEQ ID NO: 1 or a partial peptide of a coronavirus spike protein consisting of the amino acid sequence corresponding to the amino acid sequence of SEQ ID NO: 1 and a multiple antigen peptide containing a plurality of any of these peptides.
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公开(公告)号：EP3882274A1
公开(公告)日：2021-09-22
申请号：EP19863519.5
申请日：2019-09-20
发明人： MASUDA Kenichi , SAITO Takashi
摘要： The present invention provides an antibody specific to IgE antibody-producing B cells or an antibody binding fragment thereof. More specifically, the present invention provides an isolated monoclonal antibody or an antigen binding fragment thereof that binds to a peptide having a sequence consisting of an amino acid sequence set forth in SEQ ID NO: 1 or 18, and
(1) binds to IgE antibody on a B cell surface and/or
(2) binds to IgE antibody heated at 56°C.-
公开(公告)号：EP3156423A4
公开(公告)日：2018-04-11
申请号：EP15806911
申请日：2015-06-11
发明人： MASUDA KENICHI , ISHII YASUYUKI , TSUKUI TOSHIHIRO
IPC分类号： C07K17/02 , A61K39/00 , A61K39/39 , A61P19/00 , A61P25/00 , A61P27/02 , A61P35/00 , A61P37/00 , C07K7/08 , C07K16/42
CPC分类号： C07K7/08 , A61K39/00 , A61K39/39 , A61K39/3955 , A61K2039/55522 , C07K16/18 , C07K16/42 , C07K17/02 , C07K2317/34
摘要： The present invention provides a synthetic peptide capable of inducing an antibody to an autoantigen, and specifically, provides: a multiplexed same type-antigenic peptide comprising a dendritic core and B-cell recognition peptides, wherein the multiplexed same type-antigenic peptide comprises 4 to 8 B-cell recognition peptides of the same type that are bound to the terminal ends of the dendritic core directly or via a spacer, and each B-cell recognition peptide is bound to the terminal end of the dendritic core directly or via a spacer; an antibody production-inducing agent comprising the peptides; and a method for producing the peptide.
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公开(公告)号：EP3156423A1
公开(公告)日：2017-04-19
申请号：EP15806911.2
申请日：2015-06-11
IPC分类号： C07K17/02 , A61K39/00 , A61K39/39 , A61P19/00 , A61P25/00 , A61P27/02 , A61P35/00 , A61P37/00 , C07K16/42 , C07K7/08
CPC分类号： C07K7/08 , A61K39/00 , A61K39/39 , A61K39/3955 , A61K2039/55522 , C07K16/18 , C07K16/42 , C07K17/02 , C07K2317/34
摘要： The present invention provides a synthetic peptide capable of inducing an antibody to an autoantigen, and specifically, provides: a multiplexed same type-antigenic peptide comprising a dendritic core and B-cell recognition peptides, wherein the multiplexed same type-antigenic peptide comprises 4 to 8 B-cell recognition peptides of the same type that are bound to the terminal ends of the dendritic core directly or via a spacer, and each B-cell recognition peptide is bound to the terminal end of the dendritic core directly or via a spacer; an antibody production-inducing agent comprising the peptides; and a method for producing the peptide.
摘要翻译： 本发明提供能够诱导自身抗原抗体的合成肽，具体地，提供：包含树突状核和B细胞识别肽的多重相同类型的抗原肽，其中多重相同类型的抗原肽包含4〜 8个相同类型的B细胞识别肽直接或通过间隔物结合到树突核心的末端，并且每个B细胞识别肽直接或通过间隔物结合到树突核心的末端; 包含该肽的抗体产生诱导剂; 和肽的制造方法。
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6.发明公开ANTI-DOG IGE MONOCLONAL ANTIBODY, AND LIGHT-CHAIN VARIABLE REGION AND HEAVY-CHAIN VARIABLE REGION OF ANTI-DOG IGE MONOCLONAL ANTIBODY 审中-公开单克隆抗体狗和IGE轻链可变区和重链可变区单克隆抗体的狗的IgE
公开(公告)号：EP2977387A1
公开(公告)日：2016-01-27
申请号：EP14769566.2
申请日：2014-03-17
申请人： Kazusa DNA Research Institute , Animal Allergy Clinical Laboratories Inc. , Nippon Zenyaku Kogyo Co., Ltd.
发明人： OHARA, Osamu , NAGASE, Takahiro , YAMAGUCHI, Yoshihiro , OHARA, Reiko , MASUDA, Kenichi , TSUKUI, Toshihiro
CPC分类号： C07K16/4291 , A01K2217/052 , A01K2227/706 , A01K2267/01 , C07K2317/14 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2319/21 , C12N15/8509 , C12N2015/8518 , G01N33/577 , G01N33/6854
摘要： Problem to be Solved: The present invention is intended to provide a polynucleotide encoding the light-chain variable region and the heavy-chain variable region of an anti-dog IgE antibody; and an anti-dog IgE antibody containing these variable regions.
Solution: The present invention is DNA encoding a heavy-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 2 or 6 and DNA encoding a light-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 4 or 8, and an anti-dog IgE monoclonal antibody which binds to dog IgE, containing these variable regions or a functional fragment thereof which binds to dog IgE.摘要翻译： 要解决的问题：本发明的目的是提供编码轻链可变区和抗狗IgE的抗体的重链可变区的多核苷酸; 和抗犬的IgE抗体的合成含可变区。 解决方案：本发明是编码重链可变区由SEQ ID NO所代表的氨基酸序列的DNA：2或6和编码轻链可变区由SEQ ID NO所代表的氨基酸序列的DNA： 4或8，以及其结合狗IgE合成含可变区或其结合至IgE的狗的功能片段的抗狗的IgE单克隆抗体。
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