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    BIOMARKERS AND METHODS OF USE FOR RADIATION-INDUCED LUNG INJURY
    2.
    发明公开
    BIOMARKERS AND METHODS OF USE FOR RADIATION-INDUCED LUNG INJURY 审中-公开

    公开(公告)号：EP4439066A2

    公开(公告)日：2024-10-02

    申请号：EP24166259.2

    申请日：2019-10-31

    申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

    发明人： GARCIA, Joe G.N.

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2800/1220130101 ,  G01N2800/5020130101 ,  G01N2800/5220130101 ,  G01N2800/4020130101

    摘要： The present disclosure is directed to methods (e.g., in vitro methods) for use of nicotinamide phosphoribosyltransferase (NAMPT) as a biomarker in radiation-induced lung injury (RILI). Provided herein is an in vitro method for the diagnosis, prognosis, and/or monitoring of RILI in a human subject by providing a tissue or plasma sample from the subject and detecting the level of NAMPT therein, wherein a higher level of NAMPT in the tissue or plasma sample from the subject compared to a healthy control or a reference value is indicative for the presence of RILI in the subject. Further provided herein is a method of detecting NAMPT in a human subject by obtaining a biological sample from the subject, detecting the presence of NAMPT in the sample by contacting the sample with a capture agent that specifically binds NAMPT, and detecting binding between NAMPT and the capture agent.