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公开(公告)号：EP2136782B1
公开(公告)日：2013-06-05
申请号：EP08749111.4
申请日：2008-04-24
申请人： Azad Pharma AG
CPC分类号： A61K9/0048 , A61K9/107 , A61K31/557 , A61K31/5575 , A61K47/14 , A61K47/26 , A61K47/44 , Y02A50/465
摘要： The present invention refers to an oil-in-water emulsion for ophthalmic application comprising at least one prostaglandin as active agent and a surfactant component comprising a combination of at least two non-ionic surfactants. The emulsion is suitable for medical applications, particularly for the treatment of glaucoma, and has an increased chemical stability of the prostaglandin active agent so to allow long-term storage also at room temperature.
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2.发明公开Pharmaceutical microemulsion for preventing supramolecular aggregation of amphiphilic molecules 审中-公开on len len len len len len len len len len len len len len len len len len len
公开(公告)号：EP2204167A1
公开(公告)日：2010-07-07
申请号：EP09000055.5
申请日：2009-01-05
申请人： Azad Pharma AG
CPC分类号： A61K9/0019 , A61K9/1075 , A61K31/337 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention refers to a microemulsion formulation suitable for preventing assembly of amphiphilic drug molecules which may cause hypersensitivity reactions and other unwanted side effects.
摘要翻译： 本发明涉及适用于防止两亲药物分子组装的微乳液制剂，其可引起超敏反应和其它不希望的副作用。
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公开(公告)号：EP4335853A2
公开(公告)日：2024-03-13
申请号：EP24152430.5
申请日：2021-01-27
申请人： AZAD Pharma AG
发明人： Zinser, Hartmut , Danielyan, Tamar , Grigoryan, Meri , Gharibyan, Mariam , Movsisyan, Mikayel , Nerkararyan, Kristine
IPC分类号： C07D498/12
摘要： The present invention relates to a novel route of synthesis for the opioid receptor antagonist Buprenorphine or a pharmaceutically acceptable salt thereof, starting from thebaine, wherein the route comprises the reaction of thebaine with a dienophile; forming an alkylated reaction product by reaction with a Grignard-reagent; formation of an cyanamide; deprotection of the cyanamide- and the phenolic-oxygen-moiety, wherein the cleavage of one or both groups is performed in the presence of an alkali or alkaline earth sulfide; followed by derivatization with a cyclopropyl-halogen and hydrogenation to yield Buprenorphine.
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公开(公告)号：EP4097109A1
公开(公告)日：2022-12-07
申请号：EP21703165.7
申请日：2021-01-27
申请人： AZAD Pharma AG
发明人： ZINSER, Hartmut , DANIELYAN, Tamar , GRIGORYAN, Meri , GHARIBYAN, Mariam , MOVSISYAN, Mikayel , NERKARARYAN, Kristine
IPC分类号： C07D498/12
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公开(公告)号：EP3593862A1
公开(公告)日：2020-01-15
申请号：EP18183127.2
申请日：2018-07-12
申请人： Azad Pharma AG
摘要： The present application refers to an electrochemically activated salt solution (ECAS), its production, and its use for treating infections.
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公开(公告)号：EP3765448A1
公开(公告)日：2021-01-20
申请号：EP19712155.1
申请日：2019-03-13
申请人： AZAD Pharma AG
发明人： BARSEGHYAN, Karine , HAMBARDZUMYAN, Davit , GEVORGYAN, Grigor , KARAPETYAN, Dr. Vahuni , NERKARARYAN, Kristine , MAIER, Thomas
IPC分类号： C07D263/57 , A61P25/00 , A61K31/423
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7.发明公开Pharmaceutical microemulsion for preventing supramolecular aggregation of amphiphilic molecules 审中-公开on len len len len len len len len len len len len len len len len len len len len len len
公开(公告)号：EP2606877A1
公开(公告)日：2013-06-26
申请号：EP13160375.5
申请日：2010-01-05
申请人： Azad Pharma AG
CPC分类号： A61K9/0019 , A61K9/1075 , A61K31/337 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/44
摘要： The present invention refers to a microemulsion formulation suitable for preventing assembly of amphiphilic drug molecules which may cause hypersensitivity reactions and other unwanted side effects.
摘要翻译： 本发明涉及适用于防止两亲性药物分子组装的微乳液制剂，其可引起超敏反应和其它不希望的副作用。
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公开(公告)号：EP2136782A1
公开(公告)日：2009-12-30
申请号：EP08749111.4
申请日：2008-04-24
申请人： Azad Pharma AG
IPC分类号： A61K9/00 , A61K47/10 , A61K47/26 , A61K31/557 , A61K47/44
CPC分类号： A61K9/0048 , A61K9/107 , A61K31/557 , A61K31/5575 , A61K47/14 , A61K47/26 , A61K47/44 , Y02A50/465
摘要： The present invention refers to an oil-in-water emulsion for ophthalmic application comprising at least one prostaglandin as active agent and a surfactant component comprising a combination of at least two non-ionic surfactants. The emulsion is suitable for medical applications, particularly for the treatment of glaucoma, and has an increased chemical stability of the prostaglandin active agent so to allow long-term storage also at room temperature.
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9.发明公开Ophtalmic oil-in-water emulsions containing prostaglandins 审中-公开ProstaglandinhaltigeÖl-in-Wasser-Emulsionenfürdas Auge
公开(公告)号：EP1985298A1
公开(公告)日：2008-10-29
申请号：EP07008357.1
申请日：2007-04-24
申请人： Azad Pharma AG
发明人： Carli, Fabio , Baronian, Mihran , Schmid, Rene
IPC分类号： A61K31/557 , A61K9/00 , A61K47/10 , A61K47/26 , A61K47/44
CPC分类号： A61K9/0048 , A61K9/107 , A61K31/557 , A61K31/5575 , A61K47/14 , A61K47/26 , A61K47/44 , Y02A50/465
摘要： The present invention refers to an oil-in-water emulsion for ophthalmic application comprising at least one prostaglandin as active agent and a surfactant component comprising a combination of at least two non-ionic surfactants. The emulsion is suitable for medical applications, particularly for the treatment of glaucoma, and has an increased chemical stability of the prostaglandin active agent so to allow long-term storage also at room temperature.
摘要翻译： 本发明涉及用于眼科应用的水包油乳液，其包含至少一种作为活性剂的前列腺素和包含至少两种非离子表面活性剂的组合的表面活性剂组分。 该乳剂适用于医疗应用，特别是用于治疗青光眼，并且具有增加的前列腺素活性剂的化学稳定性，从而允许在室温下长期储存。
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公开(公告)号：EP3919047A1
公开(公告)日：2021-12-08
申请号：EP20178029.3
申请日：2020-06-03
申请人： AZAD Pharma AG
IPC分类号： A61K9/00 , A61K9/107 , A61K47/02 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/36 , A61P27/04
摘要： The present invention refers to a microemulsion, particularly suitable for ophthalmic applications such as treatment of dry eye syndrome, which comprises at least one oily component, an aqueous phase, at least one non-ionic surfactant, at least one polysaccharide, a salt or a derivative thereof, and at least one cross-linking agent. Moreover, the present invention relates to a process of manufacturing a microemulsion according to the invention, as well as its use in ophthalmic applications or as a carrier.
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