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    CBD FOR OCULAR USE
    2.
    发明公开
    CBD FOR OCULAR USE 审中-公开

    公开(公告)号：EP4434515A1

    公开(公告)日：2024-09-25

    申请号：EP23382276.6

    申请日：2023-03-24

    申请人： Laboratoire Laredo S.L.

    发明人： Moreno Martín, Ricardo Vidal ,  Nury, Chloé

    IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K31/00 ,  A61K33/00 ,  A61P27/04 ,  A61P27/06 ,  A61K47/02 ,  A61K47/10 ,  A61K47/36

    CPC分类号： A61K9/0048 ,  A61K31/658 ,  A61K9/1075 ,  A61P27/06 ,  A61P27/04 ,  A61K47/10 ,  A61K47/36 ,  A61K47/02

    摘要： The invention provides an aqueous micellar solution comprising micelles of poloxamer, with a hydrophilic surface and a hydrophobic nucleus encapsulating CBD, which solution can additionally comprise NaCl, H3BO3, and sodium hyaluronate, and which is for use in the prevention and/or treatment of glaucoma, and/or high intraocular pressure, ocular dryness, ocular discomfort or pain and/or high mechanical ocular sensitivity. The administration of the micellar solution in drops to the eyes gives rise to a decrease in the intraocular pressure after repeated administration, preferably for seven days or more, without increasing mechanical corneal sensitivity or spontaneous tear production. The decrease in intraocular pressure should prevent or slow glaucoma appearance or development. Compositions for the same use, comprising the aqueous micellar solution, are also provided.

    PROPHYLACTIC AGENT, AMELIORATING AGENT, AND THERAPEUTIC AGENT FOR DRY EYE
    9.
    发明公开
    PROPHYLACTIC AGENT, AMELIORATING AGENT, AND THERAPEUTIC AGENT FOR DRY EYE 审中-公开

    公开(公告)号：EP4218744A1

    公开(公告)日：2023-08-02

    申请号：EP21872565.3

    申请日：2021-09-24

    申请人： Tsubota Laboratory, Inc.

    发明人： NISHIMURA Emi

    IPC分类号： A61K31/12 ,  A61P27/04

    摘要： The present disclosure pertains to provision of: a tear layer stabilizer; a prophylactic agent, ameliorating agent, and therapeutic agent for corneal epithelial disorders; a prophylactic agent, ameliorating agent, and therapeutic agent for meibomian gland dysfunction; and a prophylactic agent, ameliorating agent, and therapeutic agent for dry eye. More specifically, provided are a tear layer stabilizer, a prophylactic agent, ameliorating agent, and therapeutic agent for corneal epithelial disorders, and a prophylactic agent, ameliorating agent, and therapeutic agent for meibomian gland dysfunction, and a prophylactic agent, ameliorating agent, and therapeutic agent for dry eye, each of which composition contains apocynin as an active ingredient.