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1.发明授权SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS 有权所产生的合成作为合适THERAPEUTICS二羟基苯甲酸内酯的
公开(公告)号：EP2242359B1
公开(公告)日：2016-06-01
申请号：EP09702521.7
申请日：2009-01-15
IPC分类号： A01N31/14 , A61K31/02 , C07D313/00 , C07D405/12 , C07D405/14
CPC分类号： C07D313/00 , A61K31/335 , A61K31/365 , A61K31/4025 , A61K31/435 , A61K31/4453 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D211/14 , C07D225/06 , C07D405/12 , C07D405/14 , Y02P20/55
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2.发明公开SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS 有权所产生的合成作为合适THERAPEUTICS二羟基苯甲酸内酯的
公开(公告)号：EP2242359A4
公开(公告)日：2011-11-09
申请号：EP09702521
申请日：2009-01-15
IPC分类号： A01N31/14 , A61K31/02 , C07D313/00 , C07D405/12 , C07D405/14
CPC分类号： C07D313/00 , A61K31/335 , A61K31/365 , A61K31/4025 , A61K31/435 , A61K31/4453 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D211/14 , C07D225/06 , C07D405/12 , C07D405/14 , Y02P20/55
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3.发明公开SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS 有权所产生的合成作为合适THERAPEUTICS二羟基苯甲酸内酯的
公开(公告)号：EP2242359A1
公开(公告)日：2010-10-27
申请号：EP09702521.7
申请日：2009-01-15
CPC分类号： C07D313/00 , A61K31/335 , A61K31/365 , A61K31/4025 , A61K31/435 , A61K31/4453 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D211/14 , C07D225/06 , C07D405/12 , C07D405/14 , Y02P20/55
摘要： Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
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公开(公告)号：EP2173733A2
公开(公告)日：2010-04-14
申请号：EP08807156.8
申请日：2008-06-05
IPC分类号： C07D313/08 , C07D321/10 , C07D327/02 , A61K31/365 , A61K31/39 , A61P25/00 , A61P29/00 , A61P31/04 , A61P35/00
CPC分类号： C07D313/00 , C07D321/00 , C07D327/02
摘要： Disclosed are novel analogues of the natural product radicicol A of formulae I,.Ia, pi, Ha, lib and HI, pharmaceutical compositions comprising the compounds. The compounds of the invention are kinase and phosphatase inhibitors and find utility in the treatment or prevention of kinase and phosphatase -mediated disorders. Also provided are uses and methods for the treatment or prevention of kinase- and phosphatase -mediated disorders and synthetic processes for the preparation of the compounds.
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