-
1.发明授权SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS 有权所产生的合成作为合适THERAPEUTICS二羟基苯甲酸内酯的
公开(公告)号：EP2242359B1
公开(公告)日：2016-06-01
申请号：EP09702521.7
申请日：2009-01-15
IPC分类号： A01N31/14 , A61K31/02 , C07D313/00 , C07D405/12 , C07D405/14
CPC分类号： C07D313/00 , A61K31/335 , A61K31/365 , A61K31/4025 , A61K31/435 , A61K31/4453 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D211/14 , C07D225/06 , C07D405/12 , C07D405/14 , Y02P20/55
-
2.发明公开SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS 有权所产生的合成作为合适THERAPEUTICS二羟基苯甲酸内酯的
公开(公告)号：EP2242359A1
公开(公告)日：2010-10-27
申请号：EP09702521.7
申请日：2009-01-15
CPC分类号： C07D313/00 , A61K31/335 , A61K31/365 , A61K31/4025 , A61K31/435 , A61K31/4453 , A61K31/4523 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D211/14 , C07D225/06 , C07D405/12 , C07D405/14 , Y02P20/55
摘要： Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
-
公开(公告)号：EP2173733A2
公开(公告)日：2010-04-14
申请号：EP08807156.8
申请日：2008-06-05
IPC分类号： C07D313/08 , C07D321/10 , C07D327/02 , A61K31/365 , A61K31/39 , A61P25/00 , A61P29/00 , A61P31/04 , A61P35/00
CPC分类号： C07D313/00 , C07D321/00 , C07D327/02
摘要： Disclosed are novel analogues of the natural product radicicol A of formulae I,.Ia, pi, Ha, lib and HI, pharmaceutical compositions comprising the compounds. The compounds of the invention are kinase and phosphatase inhibitors and find utility in the treatment or prevention of kinase and phosphatase -mediated disorders. Also provided are uses and methods for the treatment or prevention of kinase- and phosphatase -mediated disorders and synthetic processes for the preparation of the compounds.
-
公开(公告)号：EP2254880B8
公开(公告)日：2016-09-21
申请号：EP09713314.4
申请日：2009-02-23
发明人： HECK, James , WINSSINGER, Nicolas , CHABALA, John C. , BARLUENGA, Sofia , CHEN, Ruihong , RUBENSTEIN, Allan , YU, Jin-Chen
IPC分类号： C07D313/00 , C07D315/00 , A61K31/365
CPC分类号： C07D313/00
-
公开(公告)号：EP2446033A2
公开(公告)日：2012-05-02
申请号：EP10752168.4
申请日：2010-06-22
CPC分类号： C12Q1/6837 , C12N15/1068 , C40B40/06 , C40B50/04
摘要： A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, said molecular structure(s) each comprising one nucleotide chain onto which is hybridized at least one PNA-encoded molecule.
-
6.发明公开POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES 审中-公开POCHOXIMKONJUGATE为疾病相关的HSP90治疗
公开(公告)号：EP2630132A1
公开(公告)日：2013-08-28
申请号：EP11797116.8
申请日：2011-10-24
IPC分类号： C07D313/00 , C07D495/04 , C07H15/26 , A61K31/335 , A61K31/7048 , A61P35/00
CPC分类号： C07D405/12 , A61K31/4523 , A61K31/454 , A61K31/706 , C07D313/00 , C07D405/14 , C07D495/04 , C07H15/26
摘要： The present invention includes novel derivatives, analogs, and intermediates of the natural products radicicol, pochonins, pochoximes, and their syntheses. The present invention also provides a pharamceutical composition comprising the present compound and the use of the compound as inhibitors of kinases and of the enzyme family known as heat shock protein 90 (HSP90).
-
公开(公告)号：EP2254880B1
公开(公告)日：2016-08-17
申请号：EP09713314.4
申请日：2009-02-23
发明人： HECK, James , WINSSINGER, Nicolas , CHABALA, John C. , BARLUENGA, Sofia , CHEN, Ruihong , RUBENSTEIN, Allan , YU, Jin-Chen
IPC分类号： C07D313/00 , C07D315/00 , A61K31/365
CPC分类号： C07D313/00
-
公开(公告)号：EP2446033B1
公开(公告)日：2013-10-23
申请号：EP10752168.4
申请日：2010-06-22
CPC分类号： C12Q1/6837 , C12N15/1068 , C40B40/06 , C40B50/04
-
9.发明公开IRREVERSIBLE INHIBITORS USEFUL FOR THE TREATMENT OF KINASE-RELATED PATHOLOGIES 审中-公开不可逆抑制剂来治疗激酶相关疾病
公开(公告)号：EP2483259A1
公开(公告)日：2012-08-08
申请号：EP10760324.3
申请日：2010-09-28
IPC分类号： C07D313/00 , A61K31/335 , A61P35/00
CPC分类号： C07D313/00
摘要： The present invention provides new compounds (I) having a kinase inhibitory activity and useful for treating cancer.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.018 秒)
