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    SAFETY NEEDLE DEVICE
    1.
    发明公开
    SAFETY NEEDLE DEVICE 审中-公开

    公开(公告)号：EP4233939A3

    公开(公告)日：2023-11-08

    申请号：EP23185751.7

    申请日：2017-12-12

    申请人： Becton Dickinson & Company

    发明人： SMITH, Peter ,  SANDERS, Laurie ,  BROWKA, Edward P. ,  MARICI, Paul ,  NICHOLS, Eli B.

    IPC分类号： A61M5/158 ,  A61M5/32

    摘要： A safety needle device is disclosed having a housing configured to couple to a syringe, the housing having a proximal end, a distal end, and a housing body. A needle hub is disposed on the proximal end of the housing and a needle cannula is attached to the needle hub. The device having a retractable sheath configured to move between an initial position, a retracted position and an extended position with respect to the housing, wherein the initial position partially exposes a distal tip of the needle cannula, the retracted position fully exposes the needle cannula, and the extended position fully covers the distal tip of the needle cannula. The safety needle device may include an activation latch, a lockout latch, a tether and a spring element to bias the retractable sheath to an extended state to cover the distal end of the needle cannula upon completion of an injection. The safety needle device may include a slider element disposed above an activation latch. A method of drug delivery is also disclosed.

    Passively shielding needle assembly with skin sensor
    5.
    发明公开
    Passively shielding needle assembly with skin sensor 有权
    PassivschützendeNadelanordnung mit Hautsensor

    公开(公告)号：EP2638924A1

    公开(公告)日：2013-09-18

    申请号：EP13171407.3

    申请日：2010-07-29

    申请人： Becton, Dickinson & Company

    发明人： Newby, Mark C.

    IPC分类号： A61M5/158 ,  A61B5/153 ,  A61M5/32 ,  A61B5/15

    CPC分类号： A61M5/326 ,  A61B5/15003 ,  A61B5/150259 ,  A61B5/150389 ,  A61B5/150496 ,  A61B5/150519 ,  A61B5/150648 ,  A61B5/15074 ,  A61B5/150992 ,  A61B5/153 ,  A61M5/158 ,  A61M5/1626 ,  A61M5/3202 ,  A61M5/321 ,  A61M5/322 ,  A61M5/3234 ,  A61M5/3243 ,  A61M5/3245 ,  A61M2005/3107

    摘要： A shielding needle assembly comprising a needle cannula (25a) having a puncture tip (35a) at a distal end thereof; a needle hub (27a) supporting the needle cannula; a barrel (11a, 13a) having a proximal end, a distal end, and a passage extending between the ends, the needle hub being disposed in the passage of the barrel; a drive member (9a) disposed between the barrel and the needle hub for driving the needle hub from a first position in which the puncture tip of the needle cannula is exposed from the distal end of the barrel to a second position where the puncture tip of the needle cannula is disposed entirely within the barrel; and a lever (16a) pivotally connected to the barrel and including a forward portion (49a) adjacent the needle cannula when the needle hub is in the first position and adapted to contact a surface and a rearward portion (51a) including a releasable engagement (314) with the needle hub for maintaining the needle hub in the first position, wherein contact of the forward portion of the lever with a surface pivots the lever and releases an initial engagement with the needle hub at the rearward portion of the lever.

    摘要翻译： 一种屏蔽针组件，包括在其远端具有穿刺尖端（35a）的针插管（25a）; 支撑针插管的针座（27a） 具有近端，远端和在端部之间延伸的通道的筒体（11a，13a），所述针座设置在所述筒体的通道中; 驱动构件（9a），其设置在所述筒体和所述针座之间，用于从所述针插管的穿刺尖端从所述筒的远端露出的第一位置驱动所述针座，到所述第二位置，在所述第二位置， 针插管完全设置在枪管内; 以及当所述针毂处于所述第一位置并且适于接触表面的后端部分（51a）时，所述杆（16a）枢转地连接到所述筒体并且包括邻近所述针插管的前部（49a） 314），其具有用于将针座保持在第一位置的针​​座，其中，所述杆的前部与表面的接触使所述杆枢转并在所述杆的后部释放与所述针座的初始接合。

    SEQUENCE-SPECIFIC METHODS FOR HOMOGENOUS, REAL-TIME DETECTION OF LAMP PRODUCTS
    9.
    发明公开
    SEQUENCE-SPECIFIC METHODS FOR HOMOGENOUS, REAL-TIME DETECTION OF LAMP PRODUCTS 有权
    SEQUENZSPEZIFISCHE VERFAHRENFÜRHOMOGENE ECHTZEITERKENNUNG VON LAMP PRODUKTEN

    公开(公告)号：EP2496705A1

    公开(公告)日：2012-09-12

    申请号：EP10829068.5

    申请日：2010-11-04

    申请人： Becton, Dickinson & Company

    发明人： NADEAU, James, G.

    IPC分类号： C12P19/34

    CPC分类号： C12Q1/6865 ,  C12Q2525/307

    摘要： Presented herein are methods and compositions for generating sequence-specific, secondary amplification products during Loop-mediated Isothermal Amplification (LAMP). Conventional LAMP produces a preponderance of high molecular weight DNA structures concatenated into self-complementary hairpins, which are not amenable to detection by routine probe-based hybridization methods, making multiplex detection of two or more targets or sequence variants in closed-tube formats extremely difficult. Provided herein, for example, are methods for generating secondary LAMP products bearing a fragment of the original target sequence embedded within low-molecular weight products that are devoid of competitive hairpin structures, the lack of which enhances probe-based detection of target sequences. These secondary products can, for example, be produced in real-time, during the LAMP process, and can provide the option of detecting multiple target sequences within a single tube using, e.g., a homogenous, real-time fluorescence format.

    摘要翻译： 本文提出的是在环介导等温扩增（LAMP）期间产生序列特异性，二级扩增产物的方法和组合物。 常规的LAMP产生连接到自身互补发夹中的高分子量DNA结构的优势，其不适合通过常规基于探针的杂交方法的检测，使得封闭管形式中的两个或多个目标或序列变体的多重检测非常困难 。 例如，本文提供的是产生具有嵌入低分子量产物中的原始靶序列的片段的次级LAMP产物的方法，所述片段不含有竞争力的发夹结构，缺乏这种靶序列增强了靶序列的基于探针的检测。 这些次要产物可以例如在LAMP过程期间实时产生，并且可以提供使用例如均匀的实时荧光格式在单个管内检测多个靶序列的选项。