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1.发明授权SELF-DEGRADABLE ADHESIVE FOR MEDICAL USE OF TWO- COMPONENT REACTANT SYSTEM COMPRISING POWDER-POWDER 有权自消耗胶水粉粉末的两部分反应体系的医学用途
公开(公告)号：EP2100628B1
公开(公告)日：2015-04-15
申请号：EP07849957.1
申请日：2007-11-30
申请人： BMG Incorporated
CPC分类号： A61L24/0042 , A61L24/08 , A61L24/10 , A61L31/042 , A61L31/148 , C08L5/00
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公开(公告)号：EP0933089B1
公开(公告)日：2003-01-15
申请号：EP98117643.1
申请日：1998-09-17
申请人： BMG INCORPORATED
发明人： Gen, Shokyu
IPC分类号： A61L31/00
CPC分类号： A61L31/127
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公开(公告)号：EP0937468A3
公开(公告)日：2000-11-02
申请号：EP98116437.9
申请日：1998-08-31
申请人： BMG INCORPORATED
发明人： Gen, Shokyu , Nakajima, Naoki
IPC分类号： A61L25/00
CPC分类号： A61L24/043 , C08L35/04
摘要： The present invention relates to a novel adhesive composition for surgical use application comprising an α-cyanoacrylate and a polymer being biodegradable and bioabsorbable into the living body organism. It is preferred that the polymer is a co-polymer of DL-lactic acid and ε-caprolactone, or co-polymer of DL-lactic acid, ethylene glycol and ε-caprolactone, or a co-polymer of ethylene glycol and ε-caprolactone.
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4.发明公开A composition for the protection and preservation of organs, tissues or cells and the use thereof 审中-公开组成的器官，组织和细胞及其使用的保护和保全
公开(公告)号：EP2269449A3
公开(公告)日：2011-03-16
申请号：EP10012787.7
申请日：2003-08-29
申请人： BMG INCORPORATED , Komeda, Masashi
发明人： Komeda, Masashi , Hyon, Suong-Hyu , Miwa, Senri
IPC分类号： A01N1/02
摘要： The present invention provides a composition for efficiently protecting and preserving organs, tissues or cells. In particular, the present invention provides a protective composition which can be used during operations. Specifically, the present invention provides a composition for protecting and preserving organs, tissues or cells, comprising a polyphenol. A method is also provided for protecting an organ, tissue or cell in a subject, comprising 1) exposing the organ, tissue or cell to a polyphenol. Such a composition and a polyphenol is effective in protecting a function of an organ (particularly, the heart, brain, nerve, spinal cord and the like).
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5.发明公开A composition for the protection and preservation of organs, tissues or cells and the use thereof 审中-公开组成的器官，组织和细胞及其使用的保护和保全
公开(公告)号：EP2269449A2
公开(公告)日：2011-01-05
申请号：EP10012787.7
申请日：2003-08-29
申请人： BMG INCORPORATED , Komeda, Masashi
发明人： Komeda, Masashi , Hyon, Suong-Hyu , Miwa, Senri
IPC分类号： A01N1/02
摘要： The present invention provides a composition for efficiently protecting and preserving organs, tissues or cells. In particular, the present invention provides a protective composition which can be used during operations. Specifically, the present invention provides a composition for protecting and preserving organs, tissues or cells, comprising a polyphenol. A method is also provided for protecting an organ, tissue or cell in a subject, comprising 1) exposing the organ, tissue or cell to a polyphenol. Such a composition and a polyphenol is effective in protecting a function of an organ (particularly, the heart, brain, nerve, spinal cord and the like).
摘要翻译： 本发明提供了用于有效地保护和保存器官，组织或细胞的组合物。 特别地，本发明提供了可以在操作期间被使用的保护性组合物。 具体而言，本发明提供了用于保护和保存器官，组织或细胞，其包含多酚的组合物。 因此提供了一种方法，用于保护器官，组织或细胞在受试者中，其包括1）将所述器官，组织或细胞的多酚。 这样的组合物和多酚是有效地保护器官（特别是心脏，脑，神经，脊髓等）的功能。
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6.发明公开
公开(公告)号：EP2100628A1
公开(公告)日：2009-09-16
申请号：EP07849957.1
申请日：2007-11-30
申请人： BMG Incorporated
IPC分类号： A61L24/00
CPC分类号： A61L24/0042 , A61L24/08 , A61L24/10 , A61L31/042 , A61L31/148 , C08L5/00
摘要： This is to provide a medical-use adhesive having self-degradation property that enables sufficient adhesion even on wet living body portion, to which body fluid such as blood oozes out heavily, and even especially when the wet living body portion is arranged along a vertical plane. This is to provide also a medical-use adhesive excellent in obliteration of a pinhole. A first part of two-part adhesive is powder of aldehyde-groups-introduced alpha-glucan having a weight-average molecular weight in a range of 1000 to 200,000. A second part of two-part adhesive is aqueous solution or powder of amino-groups-containing polymer that is formed of a polymer chain of amino-group-containing units and has a molecular weight in a range of 1000 to 20,000. A mixture of the first and second liquids at a time of mixing them has pH in a range of 5.0 to 8.0.
摘要翻译： 这是为了提供一个具有医疗用途粘合剂自降解性能确实允许足够的粘合性，即使在潮湿的活体部位，向其中体液：诸如血液渗出严重，甚至特别喜欢当湿活体部沿垂直布置 平面。 这是为了提供这样优异的针孔的闭塞医疗用粘合剂。 两部分粘合剂的第一部分是醛的基团引入具有范围内的重均分子量为1,000〜200,000的α-葡聚糖的粉末。 两部分粘合剂的第二部分是wässrige溶液或粉末氨基的基团的含聚合物没有形成的含有氨基的基团的单元的聚合物链的，并具有在至20,000的范围内的1,000的分子量。 在将它们混合的时间，第一和第二液体的混合物的pH在〜8.0的范围内的5.0。
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7.发明公开SELF-DEGRADABLE TWO-COMPONENT REACTIVE ADHESIVE FOR MEDICAL USE AND RESIN FOR MEDICAL USE 有权SELBSTABBAUBARER反应性的两个组分胶用于医疗用途医疗用树脂
公开(公告)号：EP1849486A1
公开(公告)日：2007-10-31
申请号：EP06712686.2
申请日：2006-01-31
申请人： BMG INCORPORATED
IPC分类号： A61L24/00 , C09J103/00 , C09J105/00
CPC分类号： A61L24/10 , A61L24/08 , A61L24/108 , C08B37/0021 , C08H1/00 , C08L5/02 , C08L89/00 , C08L2666/26 , C09J105/02 , C09J189/00
摘要： It is aimed to provide medical-use adhesive and medical-use hydrogel resin that satisfy general requirements for such adhesive and resin and are rapidly disintegrated at an elapse of designed time period, which may be rather freely controlled or adjusted. A first liquid for the adhesive or the resin is an aqueous solution of aldehyde-groups-introduced alpha-glucan having a weight-average molecular weight in a range of 1000 to 200,000. A second liquid for the adhesive or the resin is aqueous solution of amino-groups-containing polymer that is formed of a polymer chain of amino-group-containing units and has a molecular weight in a range of 1000 to 20,000. A mixture of the first and second liquids at a time of mixing them has pH in a range of 5.0 to 8.0.
摘要翻译： 它的目的在于提供医疗用粘合剂和医疗用树脂的水凝胶也满足寻求粘合剂和树脂并且在设计TIMEPERIOD，其可自由地而控制或调节的流逝被快速崩解的一般要求。 用于粘合剂或树脂A第一液体是醛的基团引入具有范围内的重均分子量为1,000〜200,000的α-葡聚糖的wässrige溶液。 用于粘合剂或树脂A第二液体是含氨基的基团的聚合物的溶液wässrige没形成的氨基基团的单元的聚合物链的，并具有在至20,000的范围内的1,000的分子量。 在将它们混合的时间，第一和第二液体的混合物的pH在〜8.0的范围内的5.0。
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8.发明公开Bone-adherent implant with shock-absorbing property and manufacturing method thereof 有权Knochenkontaktierendes植入有用于其生产的吸震性能和方法
公开(公告)号：EP1477192A1
公开(公告)日：2004-11-17
申请号：EP04011276.5
申请日：2004-05-12
申请人： BMG INCORPORATED
CPC分类号： A61L27/34 , A61L27/50 , Y10T428/31692 , Y10T428/31855
摘要： Bone-adherent implant with shock-absorbing property comprising: a substrate; a first film on the substrate, which is comprised of a polymer and has a functional group that enables adsorption of calcium ions; and a second film formed on the first film and being comprised of calcium phosphate. A manufacturing method of the implant comprising: forming said first film on a substrate; and subsequently, dipping the substrate in a calcium ion solution and in a phosphate ion solution alternately so as to form the second film.
摘要翻译： 骨粘附植入物冲击吸收特性，其包括：基板; 第一电影在基板上，在所有这是由聚合物构成，并具有一个官能团没有启用的钙离子的吸附; 和第二膜形成在所述第一膜和被包括磷酸钙。 所述植入物包括的制造方法：形成所述上基板的第一部电影; 并且随后，在钙离子溶液和磷酸根离子溶液中浸渍基板可替换地，以形成所述第二电影。
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公开(公告)号：EP4338590A1
公开(公告)日：2024-03-20
申请号：EP22807260.9
申请日：2022-03-29
申请人： BMG INCORPORATED
发明人： AIZAWA Akira , HYON Suong-Hyu , HYON Woogi
摘要： Provided are a cold storage method and a cold storage liquid that are suitable for non-freezing refrigerated storage of human or animal stem cells such as iPS cells or embryos in a non-frozen state. According to an embodiment, the non-freezing refrigerated storage liquid is: a mixture liquid (HTMα, HTMx2c13), in which MEM-alpha (Minimum Essential Medium Eagle (MEM) Alpha Modification) is mixed with a UW solution (UW_sln; BELZER UW (registered trademark) COLD STORAGE SOLUTION), or a modified UW solution (polymer component being changed to PVA), are mixed in a ratio of about 1/1 to 1/2; or a storage liquid having a composition equivalent to the mixture liquid, especially in respect of concentrations of potassium ions and sodium ions. And, arousal period(s) of maintaining a temperature of 30°C to 37°C is inserted at each of two to five days, into a non-freezing refrigerated storage period, which is made at 2°C to 8°C for 2 to 10 days or 4 to 20 days.
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公开(公告)号：EP0937468B1
公开(公告)日：2009-09-30
申请号：EP98116437.9
申请日：1998-08-31
申请人： BMG INCORPORATED
发明人： Gen, Shokyu , Nakajima, Naoki
IPC分类号： A61L24/04
CPC分类号： A61L24/043 , C08L35/04
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