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    SELF-DEGRADABLE ADHESIVE FOR MEDICAL USE OF TWO-COMPONENT REACTANT SYSTEM COMPRISING POWDER-LIQUID OR POWDER-POWDER
    2.
    发明公开
    SELF-DEGRADABLE ADHESIVE FOR MEDICAL USE OF TWO-COMPONENT REACTANT SYSTEM COMPRISING POWDER-LIQUID OR POWDER-POWDER 有权
    自消耗胶水粉粉末的两部分反应体系的医学用途

    公开(公告)号：EP2100628A1

    公开(公告)日：2009-09-16

    申请号：EP07849957.1

    申请日：2007-11-30

    申请人： BMG Incorporated

    发明人： NAKAJIMA, Naoki ,  SUGAI, Hajime ,  KONDA, Masakazu ,  HYON, Suong-Hyu

    IPC分类号： A61L24/00

    CPC分类号： A61L24/0042 ,  A61L24/08 ,  A61L24/10 ,  A61L31/042 ,  A61L31/148 ,  C08L5/00

    摘要： This is to provide a medical-use adhesive having self-degradation property that enables sufficient adhesion even on wet living body portion, to which body fluid such as blood oozes out heavily, and even especially when the wet living body portion is arranged along a vertical plane. This is to provide also a medical-use adhesive excellent in obliteration of a pinhole. A first part of two-part adhesive is powder of aldehyde-groups-introduced alpha-glucan having a weight-average molecular weight in a range of 1000 to 200,000. A second part of two-part adhesive is aqueous solution or powder of amino-groups-containing polymer that is formed of a polymer chain of amino-group-containing units and has a molecular weight in a range of 1000 to 20,000. A mixture of the first and second liquids at a time of mixing them has pH in a range of 5.0 to 8.0.

    摘要翻译： 这是为了提供一个具有医疗用途粘合剂自降解性能确实允许足够的粘合性，即使在潮湿的活体部位，向其中体液：诸如血液渗出严重，甚至特别喜欢当湿活体部沿垂直布置 平面。 这是为了提供这样优异的针孔的闭塞医疗用粘合剂。 两部分粘合剂的第一部分是醛的基团引入具有范围内的重均分子量为1,000〜200,000的α-葡聚糖的粉末。 两部分粘合剂的第二部分是wässrige溶液或粉末氨基的基团的含聚合物没有形成的含有氨基的基团的单元的聚合物链的，并具有在至20,000的范围内的1,000的分子量。 在将它们混合的时间，第一和第二液体的混合物的pH在〜8.0的范围内的5.0。

    SELF-DEGRADABLE TWO-COMPONENT REACTIVE ADHESIVE FOR MEDICAL USE AND RESIN FOR MEDICAL USE
    3.
    发明公开
    SELF-DEGRADABLE TWO-COMPONENT REACTIVE ADHESIVE FOR MEDICAL USE AND RESIN FOR MEDICAL USE 有权
    SELBSTABBAUBARER反应性的两个组分胶用于医疗用途医疗用树脂

    公开(公告)号：EP1849486A1

    公开(公告)日：2007-10-31

    申请号：EP06712686.2

    申请日：2006-01-31

    申请人： BMG INCORPORATED

    发明人： NAKAJIMA, Naoki ,  HYON, Suong-Hyu ,  KONDA, Masakazu

    IPC分类号： A61L24/00 ,  C09J103/00 ,  C09J105/00

    CPC分类号： A61L24/10 ,  A61L24/08 ,  A61L24/108 ,  C08B37/0021 ,  C08H1/00 ,  C08L5/02 ,  C08L89/00 ,  C08L2666/26 ,  C09J105/02 ,  C09J189/00

    摘要： It is aimed to provide medical-use adhesive and medical-use hydrogel resin that satisfy general requirements for such adhesive and resin and are rapidly disintegrated at an elapse of designed time period, which may be rather freely controlled or adjusted. A first liquid for the adhesive or the resin is an aqueous solution of aldehyde-groups-introduced alpha-glucan having a weight-average molecular weight in a range of 1000 to 200,000. A second liquid for the adhesive or the resin is aqueous solution of amino-groups-containing polymer that is formed of a polymer chain of amino-group-containing units and has a molecular weight in a range of 1000 to 20,000. A mixture of the first and second liquids at a time of mixing them has pH in a range of 5.0 to 8.0.

    摘要翻译： 它的目的在于提供医疗用粘合剂和医疗用树脂的水凝胶也满足寻求粘合剂和树脂并且在设计TIMEPERIOD，其可自由地而控制或调节的流逝被快速崩解的一般要求。 用于粘合剂或树脂A第一液体是醛的基团引入具有范围内的重均分子量为1,000〜200,000的α-葡聚糖的wässrige溶液。 用于粘合剂或树脂A第二液体是含氨基的基团的聚合物的溶液wässrige没形成的氨基基团的单元的聚合物链的，并具有在至20,000的范围内的1,000的分子量。 在将它们混合的时间，第一和第二液体的混合物的pH在〜8.0的范围内的5.0。

    TWO-REACTANT SHEET-FORM TISSUE-ADHESIVE-REINFORCING MATERIAL
    5.
    发明公开
    TWO-REACTANT SHEET-FORM TISSUE-ADHESIVE-REINFORCING MATERIAL 审中-公开

    公开(公告)号：EP3895890A1

    公开(公告)日：2021-10-20

    申请号：EP19895351.5

    申请日：2019-12-09

    申请人： BMG INCORPORATED

    发明人： TANIDA, Shuhei ,  FUJIMURA, Motoki ,  KOJITANI, Yusuke ,  OSADA, Shinichi ,  HYON, Woogi ,  HYON, Suong-Hyu

    IPC分类号： B32B27/00 ,  C08G81/00 ,  A61L15/26 ,  A61L15/28 ,  A61L15/32 ,  A61L15/42 ,  A61L15/44 ,  A61L15/58 ,  A61L15/64

    摘要： A sheet-shaped tissue adhesive/reinforcement and its producing method in a manner as below, which realizes a good tissue reinforcing effect and handleability without the need to utilize fibrinogen and the blood coagulation ability derived from the patient being applied. The sheet-shaped tissue adhesive reinforcement comprises a base sheet having a biodegradability and communicative porous structure, and an adhesive resin layer fixed and formed on the base sheet. This adhesive resin layer comprises a first reactant comprising an aldehyded glycan and a second reactant comprising partially carboxylated polylysine, and has a granular structure derived from the powder of the first reactant and a connecting layer, which is derived from the second reactant and connects the granular structures to each other and fixes them to the base sheet. In a way to produce such reinforcement, a mixed powder of the first and second reactant is used. For example, this mixed powder is dispersed in ethanol having a water content of less than 1%, and the dispersion is applied onto the base sheet and then dried.