-
公开(公告)号：EP4269385A1
公开(公告)日：2023-11-01
申请号：EP23163489.0
申请日：2023-03-22
申请人： Beijing Jitai Pharmaceutical Technology Co., Ltd. , Hangzhou Jitai Pharmaceutical Technology Co., Ltd.
发明人： ZHANG, Lin , YANG, Liu , LIU, Andong , LAI, Caida , WANG, Wenshou
IPC分类号： C07C229/12 , C07D207/08 , C07D211/08 , C07D211/16 , C07D223/04 , C07D265/30 , A61K9/51 , C07C235/06 , C07C271/22 , C07C275/16 , C07C327/22 , C07C329/06
摘要： Provided herein is a class of ionizable lipid compounds represented by formula (IV), or pharmaceutically acceptable salts, isotopic variants, tautomers or stereoisomers thereof. Also provided is a nanoparticle pharmaceutical composition comprising said compound, and the application of said compound and its composition in the delivery of nucleic acids.
-
公开(公告)号：EP4360745A1
公开(公告)日：2024-05-01
申请号：EP23163498.1
申请日：2023-03-22
申请人： Beijing Jitai Pharmaceutical Technology Co., Ltd. , Hangzhou Jitai Pharmaceutical Technology Co., Ltd.
发明人： LIU, Andong , YANG, Liu , JIANG, Tian , LAI, Caida , WANG, Wenshou
CPC分类号： B01F33/30 , B01F35/7174 , B01F35/1452 , B01F25/431 , B01F23/41 , B01F33/813 , B01J19/2425
摘要： A nanoparticle preparation system, a control method of the nanoparticle preparation system, an electronic device, a non-transitory computer readable medium, and a method for preparing nanoparticles using the nanoparticle preparation system are disclosed. The nanoparticle preparation system includes a mixing element, a first liquid suction device and a second liquid suction device. The mixing element includes a plurality of mixing channels; the first liquid suction device includes a plurality of first liquid suction tubes arranged in rows along a first direction and configured to input a first preparation solution into the plurality of mixing channels through first inlets of the mixing channels, respectively; and the second liquid suction device includes a plurality of second liquid suction tubes arranged in rows along a second direction and configured to input a second preparation solution into the plurality of mixing channels through second inlets of the mixing channels, respectively.
-
公开(公告)号：EP4385523A1
公开(公告)日：2024-06-19
申请号：EP23173305.6
申请日：2023-05-15
申请人： Beijing Jitai Pharmaceutical Technology Co., Ltd. , Hangzhou Jitai Pharmaceutical Technology Co., Ltd.
发明人： YANG, Liu , LANG, Jiayan , ZHANG, Lin , JIANG, Tian , WANG, Xuhui , LEI, Jiani , LIU, Andong , LAI, Caida , WANG, Wenshou
CPC分类号： A61K47/6929 , A61K47/543 , A61K9/5123 , A61K9/0019 , C12N15/88 , A61K48/0041 , A61K48/0075
摘要： The present disclosure relates to a lipid-based topical injection formulation comprising a Long-Acting SusTained delivering lipid, a structured lipid, a polymer-conjugated lipid and an ionizable lipid, and optionally a neutral phospholipid. The lipid-based topical injection formulation enables enriched delivery of drugs at an injection site and efficient expression of proteins for a prolonged period of time. The present disclosure also relates to a method of preparing the lipid-based topical injection formulation, and use of the lipid-based topical injection formulation in the delivery of biologically active substances such as nucleic acids (e.g., mRNA, miRNA, siRNA, saRNA, ASO, DNA, etc.).
-
公开(公告)号：EP4332087A1
公开(公告)日：2024-03-06
申请号：EP23163495.7
申请日：2023-03-22
申请人： Beijing Jitai Pharmaceutical Technology Co., Ltd. , Hangzhou Jitai Pharmaceutical Technology Co., Ltd.
发明人： YANG, Liu , YIN, Le , LIU, Andong , ZHANG, Lin , LAI, Caida , WANG, Wenshou
IPC分类号： C07C229/12 , A61K9/00 , C07D207/08 , C12N15/11 , C07D211/08 , C07D211/16 , C07D223/04 , C07D265/30 , A61K9/51 , C07C235/06 , C07C271/22 , C07C275/16 , C07C327/22 , C07C329/06
摘要： The present disclosure provides a lipid nanoparticle wherein the lipid ingredient comprises a compound of formula (IV). The present disclosure also provides a method of preparing the lipid nanoparticle, a pharmaceutical composition of the lipid nanoparticle, and use of the lipid nanoparticle and pharmaceutical compositions in the delivery of nucleic acids.
-
-
-
搜索结果
4 条记录 (耗时 0.021 秒)
