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公开(公告)号：EP1306127B2
公开(公告)日：2011-09-07
申请号：EP01204096.0
申请日：2001-10-26
IPC分类号： B01J13/04 , B01J13/14 , B01J13/06 , B01J13/10 , B01J13/12 , B01J19/18 , B01D61/14 , A61K9/50 , A61K9/51
CPC分类号： B01D61/145 , B01D61/142 , B01D61/16 , B01D2311/04 , B01D2311/08 , B01J13/04 , B01J13/06 , B01J13/10 , B01J13/12 , B01J13/14 , B01J19/18 , B01J2219/00006 , B01J2219/00033 , B01J2219/0004 , B01D2311/12 , B01D2311/165 , B01D2311/10
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2.发明授权CONTROLLED RELEASE COMPOSITIONS FOR INTERFERON BASED ON PEGT/PBT BLOCK COPOLYMERS 有权控释组合物干扰素为基础的PEGT / PBT嵌段共聚物
公开(公告)号：EP1843749B1
公开(公告)日：2009-05-13
申请号：EP06700417.6
申请日：2006-01-06
发明人： BECHET, Anne, Chantal , VAN DIJKHUIZEN-RADERSMA, Riemke , STIGTER, Martin , BEZEMER, Jeroen, Mattijs
CPC分类号： A61K38/212 , A61K9/0024 , A61K9/1647 , A61K38/21 , A61K47/34
摘要： The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an in-jectable liquid which may have self-gelling properties, or of a solid implant. The inven-tion further provides a pharmaceutical kit comprising the composition, methods for pre-paring the composition, and the pharmaceutical uses relating thereto.
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公开(公告)号：EP2396416A1
公开(公告)日：2011-12-21
申请号：EP10741539.0
申请日：2010-02-16
发明人： WILLIAMS, David, G.
IPC分类号： C12P21/06
CPC分类号： C07K16/2887 , C07K2317/13 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/734 , C07K2317/92
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公开(公告)号：EP1973935A2
公开(公告)日：2008-10-01
申请号：EP07797081.2
申请日：2007-01-17
IPC分类号： C07K14/415 , C12N15/82 , A01H5/00
CPC分类号： C12N15/8216 , C07K14/415 , C12N9/2442 , C12N9/88 , C12N15/8221 , C12N15/8222 , C12N15/8223 , C12Y302/01014 , C12Y401/01039
摘要： Compositions and methods for regulating expression of nucleotide sequences of interest in a plant are provided. Compositions include novel nucleic acid molecules, and variants and fragments thereof, for expression control elements isolated from the Lemnaceae ubiquitin, r-histone and chinatase genes. A method for expressing a nucleotide sequence of interest in a plant using the expression control elements disclosed herein is further provided. Also provided is a novel Lemnaceae signal peptide-encoding sequence and the signal peptide encoded thereby. Where an expression construct of the invention is designed to express a polypeptide of interest, this novel signal peptide-encoding sequence can be included within the expression construct of the invention to provide for extracellular secretion of the encoded polypeptide of interest.
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公开(公告)号：EP2367566A2
公开(公告)日：2011-09-28
申请号：EP09760072.0
申请日：2009-11-30
IPC分类号： A61K39/00
摘要： The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be expressed in plants including duckweed. The invention also encompasses recombinant vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals against influenza. It encompasses also a vaccination regimen compatible with the DIVA strategy, including a prime-boost scheme using vector and subunit vaccines.
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公开(公告)号：EP2325197A3
公开(公告)日：2011-07-27
申请号：EP11154225.4
申请日：2007-01-17
IPC分类号： C07K14/415 , C12N15/82 , A01H5/00
CPC分类号： C12N15/8216 , C07K14/415 , C12N9/2442 , C12N9/88 , C12N15/8221 , C12N15/8222 , C12N15/8223 , C12Y302/01014 , C12Y401/01039
摘要： Compositions and methods for regulating expression of nucleotide sequences of interest in a plant are provided. Compositions include novel nucleic acid molecules, and variants and fragments thereof, for expression control elements isolated from the Lemnaceae ubiquitin, r-histone and chitinase genes. A method for expressing a nucleotide sequence of interest in a plant using the expression control elements disclosed herein is further provided. The method includes introducing into a plant or plant cell or nodule an expression construct comprising an expression control element of the present invention operably linked to a nucleotide sequence of interest. In particular, the compositions and methods find use in enhancing expression of nucleotide sequences of interest in duckweed. Also provided is a novel Lemnaceae signal peptide-encoding sequence and the signal peptide encoded thereby. Where an expression construct of the invention is designed to express a polypeptide of interest, this novel signal peptide-encoding sequence can be included within the expression construct of the invention to provide for extracellular secretion of the encoded polypeptide of interest.
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公开(公告)号：EP1305437B1
公开(公告)日：2010-09-01
申请号：EP01967946.3
申请日：2001-07-26
发明人： STOMP, Anne-Marie , DICKEY, Lynn , GASDASKA, John
CPC分类号： C07K14/56 , C12N15/8216 , C12N15/8257
摘要： Methods, nucleic acid sequences, and transformed duckweed plant or duckweed nodule cultures for the expression and the secretion of biologically active polypeptides from genetically engineered duckweed are provided. Expression of recombinant polypeptides in duckweed is improved by modifying the nucleotide sequence of the expression cassette encoding the polypeptide for improved expression in duckweed. Recovery of biologically active polypeptides from duckweed is improved by linking the biologically active polypeptide to a signal peptide that directs the secretion of the polypeptide into the culture medium.
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公开(公告)号：EP1397676B1
公开(公告)日：2009-12-30
申请号：EP02726945.5
申请日：2002-05-30
CPC分类号： G01N33/5097 , C12N15/8257 , C12Q1/6897
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9.发明公开COMPOSITIONS AND METHODS FOR HUMANIZATION AND OPTIMIZATION OF N-GLYCANS IN PLANTS 有权组合物和方法N-聚糖在植物中的人性化和优化
公开(公告)号：EP1974040A2
公开(公告)日：2008-10-01
申请号：EP07718188.1
申请日：2007-01-17
CPC分类号： C07K14/47 , C07K16/00 , C07K2317/13 , C07K2317/41 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C12N15/8257 , C12N15/8258
摘要： Methods for altering the N-glycosylation pattern of proteins in higher plants are provided. The methods comprise introducing into the plant a recombinant construct that provides for the inhibition of expression of αl,3-fucosyltransferase (FucT) and β 1,2-xylosyltransferase (XyIT) in a plant. Use of these constructs to inhibit or suppress expression of both of these enzymes, and isoforms thereof, advantageously provides for the production of endogenous and heterologous proteins having a 'humanized' N-glycosylation pattern without impacting plant growth and development. Stably transformed higher plants having this protein N-glycosylation pattern are provided. Glycoprotein compositions, including monoclonal antibody compositions, having substantially homogeneous glycosylation profiles, and which are substantially homogeneous for the GO glycoform, are also provided.
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公开(公告)号：EP3168307A1
公开(公告)日：2017-05-17
申请号：EP16184378.4
申请日：2009-11-30
发明人： GUO, Xuan , BUBLOT, Michel , PRITCHARD, Joyce A , DICKEY, Lynn F
IPC分类号： C12N15/82 , A61K39/00 , A61K39/12 , A61K39/145
摘要： The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be expressed in plants including duckweed. The invention also encompasses recombinant vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals against influenza. It encompasses also a vaccination regimen compatible with the DIVA strategy, including a prime-boost scheme using vector and subunit vaccines.
摘要翻译： 本发明包括流感疫苗，特别是禽流感疫苗。 疫苗可能是基于流感血凝素的亚单位疫苗。 血凝素可以在包括浮萍的植物中表达。 本发明还包括编码和表达流感抗原，表位或免疫原的重组载体，所述流感抗原，表位或免疫原可用于保护动物抵抗流感。 它还包括与DIVA策略相容的疫苗接种方案，包括使用载体和亚单位疫苗的初免 - 加强方案。
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