公开(公告)号：EP3787702B1

公开(公告)日：2024-08-07

申请号：EP19725422.0

申请日：2019-05-02

IPC分类号： C07K14/78 ,  C08B37/00 ,  C08L5/08 ,  C08L89/06 ,  A61L27/26 ,  C12N15/82 ,  C08H1/06

CPC分类号： C07K14/78 ,  C08B37/0075 ,  C08H1/06 ,  A61L27/26 ,  A61L2400/0620130101 ,  C08L5/08 ,  C08L89/06 ,  C12N15/8257

公开(公告)号：EP4402271A1

公开(公告)日：2024-07-24

申请号：EP22789883.0

申请日：2022-09-15

申请人： Universidad de Castilla la Mancha ,  Consejo Superior De Investigaciones Científicas ,  Universitat Politècnica de València

发明人： GÓMEZ GÓMEZ, María Lourdes ,  AHRAZEM EL KADIRI, Oussama ,  GRANELL RICHART, Antonio ,  RUBIO MORAGA, Ángela ,  ARGANDOÑA PICAZO, Javier ,  PRESA, Silvia ,  RAMBLA, Jose Luis

IPC分类号： C12N15/82 ,  C12N9/02 ,  C12N9/10 ,  C12P7/44

CPC分类号： C12N15/8257 ,  C12N9/0083 ,  C12N9/1051 ,  C12N15/825 ,  C12N15/52 ,  C12N9/0004 ,  C12Y204/01271 ,  C12P7/625 ,  A23L33/105 ,  A23L27/63 ,  A23L23/00 ,  A23L2/02

公开(公告)号：EP3377622A1

公开(公告)日：2018-09-26

申请号：EP16867085.9

申请日：2016-11-16

申请人： The Trustees of The University of Pennsylvania

发明人： DANIELL, Henry

IPC分类号： C12N15/05 ,  C12N15/11 ,  A61K38/28 ,  A61P3/10 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565

CPC分类号： C12N15/8257 ,  A61K9/0053 ,  A61K9/48 ,  A61K36/00 ,  A61K38/00 ,  C07K14/28 ,  C07K14/435 ,  C07K14/4723 ,  C07K14/705 ,  C07K14/70596 ,  C07K14/71 ,  C07K2319/00 ,  C07K2319/60 ,  C07K2319/80 ,  C12N15/8258

摘要： Compositions and methods for producing therapeutic fusion proteins comprising targeting sequences directing the protein to cells or tissues of interest are disclosed.

公开(公告)号：EP2932825B1

公开(公告)日：2018-09-19

申请号：EP13865132.8

申请日：2013-12-17

申请人： Republic Of Korea (Management : Rural Development Administration)

发明人： BAEK, So Hyeon ,  SHIN, Woon Chul ,  MO, Young Jun ,  KIM, Bo Kyong ,  HONG, Seong Tshool ,  KIM, Sun Yeou ,  KWEON, Soon Jong

IPC分类号： C12N9/10 ,  C12N15/82 ,  A61K31/05

CPC分类号： C12N15/8243 ,  A23L7/196 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/05 ,  A61K36/899 ,  C12N9/1029 ,  C12N15/8257 ,  C12Y203/01095

摘要： The present invention relates to resveratrol-enriched transgenic rice for biosynthesizing resveratrol at high concentration, in which resveratrol synthase genes are expressibly inserted into the 12 th chromosome of natural rice, and seed of rice produced therefrom. Further, the present invention relates to a health functional food composition, an animal feed composition, and a pharmaceutical composition for preventing and improving a metabolic disease, including seed of rice produced from the resveratrol-enriched transgenic rice for biosynthesizing resveratrol, in which resveratrol synthase genes are expressibly inserted into the 12 th chromosome of natural rice. The seed of rice produced from resveratrol-enriched transgenic rice into which resveratrol synthase genes are inserted, containing high a concentration of resveratrol of the present invention exhibits remarkably superior effects compared to when the same amount of resveratrol is simply ingested. Further, since rice is produced in the form to be used directly as food without an additional process of separating or extracting resveratrol, it may be widely used as food, feed, and medical supplies for preventing and improving a metabolic disease.

公开(公告)号：EP2443234B1

公开(公告)日：2018-08-15

申请号：EP10731460.1

申请日：2010-06-10

申请人： Icon Genetics GmbH

发明人： WETERINGS, Koen ,  VAN ELDIK, Gerben

IPC分类号： C12N9/10 ,  C12N15/82

CPC分类号： C12N9/1077 ,  C12N15/8257 ,  C12N15/8258

摘要： The invention provides Nicotiana benthamiana mutant plants which are incapable of forming xylosyl-structures on glycoproteins. In addition, the invention provides methods for the production of heterologous glycoproteins in said mutant plants.

公开(公告)号：EP2575429B1

公开(公告)日：2018-08-08

申请号：EP11722787.6

申请日：2011-05-24

申请人： BioMass Booster, S.L.

发明人： MARTINEZ RAMIREZ, Alfredo ,  ARENAS VIDAL, Jorge Conrado

IPC分类号： A01H4/00 ,  A01N63/00 ,  C07K14/575 ,  C12N1/12 ,  C12N5/00 ,  A01N65/08 ,  A01N65/44 ,  C07K14/435 ,  A01H3/04 ,  C07K14/415 ,  C12N15/82

CPC分类号： A01H3/04 ,  A01H4/001 ,  A01N63/00 ,  A01N65/08 ,  A01N65/44 ,  C07K14/415 ,  C07K14/435 ,  C07K14/575 ,  C12N1/12 ,  C12N5/0025 ,  C12N15/8257 ,  C12N15/8261 ,  Y02A40/146

摘要： The invention relates to the use of a peptide comprising a six-member ring created by the disulfide bond between two cysteines in the increase of plant biomass, for its application in the wood industry, in obtaining energy coming from renewable sources and in agriculture.

公开(公告)号：EP3353195A1

公开(公告)日：2018-08-01

申请号：EP16848123.2

申请日：2016-09-22

申请人： Novozymes A/S

发明人： LIU, Ye ,  TANG, Lan ,  JIANG, Xianzhi ,  HAN, Bucong ,  KAI, Christine

IPC分类号： C07K14/37 ,  C12N9/42

CPC分类号： C12N9/2437 ,  C12N15/8257 ,  C12Y302/01091 ,  C12Y302/01176

摘要： Disclosed herein are polypeptides having cellobiohydrolase activity, catalytic domains, carbohydrate binding modules and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding modules. Disclosed herein are nucleic acid constructs, vectors and host cells comprise the polynucleotides as well as their uses, and methods of producing the polypeptides, catalytic domains, carbohydrate binding modules.

公开(公告)号：EP2809780B1

公开(公告)日：2018-05-02

申请号：EP13711558.0

申请日：2013-01-31

申请人： Protalix Ltd.

发明人： SHAALTIEL, Yoseph ,  HANANIA, Uri ,  KIZHNER, Tali ,  MATIUHIN, Yulia ,  FUX, Liat ,  SHULMAN, Avidor

IPC分类号： A61K38/46 ,  A61K38/47 ,  A61K45/06 ,  A61K9/00 ,  A61K33/06 ,  A61K33/14 ,  C12N15/82 ,  C12N9/22 ,  A61K9/14

CPC分类号： A61K38/465 ,  A61K9/007 ,  A61K9/0075 ,  A61K9/14 ,  A61K33/06 ,  A61K33/14 ,  A61K38/47 ,  A61K45/06 ,  C12N9/22 ,  C12N15/8221 ,  C12N15/8257 ,  C12Y301/21001 ,  C12Y302/01052

摘要： DNase I formulations for pulmonary administration and, more particularly, but not exclusively, a dry powder formulation comprising, as an active ingredient, human DNase I, methods, dry powder inhalation devices and systems for the therapeutic use thereof are provided.

公开(公告)号：EP3307900A1

公开(公告)日：2018-04-18

申请号：EP16732964.8

申请日：2016-06-10

申请人： Danmarks Tekniske Universitet ,  Københavns Universitet

发明人： FRANDSEN, Rasmus John Normand ,  MORTENSEN, Uffe Hasbro ,  COUMOU, Hilde Cornelijne ,  KANNANGARA, Rubini Maya ,  MADSEN, Bjørn ,  NAFISI, Majse ,  ANDERSEN-RANBERG, Johan ,  KONGSTAD, Kenneth Thermann ,  OKKELS, Finn Thyge ,  KHORSAND-JAMAL, Paiman ,  STÆRK, Dan ,  MØLLER, Birger Lindberg

IPC分类号： C12P7/26 ,  C12P7/40 ,  C12P15/00 ,  C12P17/06 ,  C12P19/60 ,  C12N1/15 ,  C12N1/19 ,  C12N15/82

CPC分类号： C12N15/8257 ,  C12N9/93 ,  C12P5/005 ,  C12P7/26 ,  C12P7/40 ,  C12P17/06 ,  C12P19/60 ,  C12Y203/01 ,  C12Y604/00 ,  C40B50/06

摘要： A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.

公开(公告)号：EP2588494B1

公开(公告)日：2018-03-07

申请号：EP11729401.7

申请日：2011-06-23

申请人： DSM IP Assets B.V.

发明人： SCHOONEVELD-BERGMANS, Margot, Elisabeth, Francoise ,  HEIJNE, Wilbert, Herman, Marie ,  DAMVELD, Robbertus, Antonius ,  DE JONG, René, Marcel

IPC分类号： C07K14/37 ,  C12N9/24 ,  C12N9/42 ,  C12N15/82 ,  C12P19/02

CPC分类号： C12N9/2445 ,  C12N9/2434 ,  C12N9/2437 ,  C12N15/8257 ,  C12P19/02 ,  C12P19/14 ,  C12P2203/00 ,  C12Y302/01021

摘要： The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 96% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 96% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.