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公开(公告)号：EP1796688B1
公开(公告)日：2011-05-18
申请号：EP05794315.1
申请日：2005-09-02
IPC分类号： A61K31/704 , A61P35/00
CPC分类号： A61K31/704
摘要： The reagent, pharmaceutical formulation, kit, and methods of the invention provides a new approach for treating pancreatic cancers. The invention provides the use of Na+/K+-ATPase inhibitors, such as cardiac glycosides (e.g. ouabain and proscillaridin, etc.), either alone or in combination with other standard therapeutic agents (chemo- or radio-therapies, etc.) for treating pancreatic cancers.
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2.发明公开MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES FOR THE TREATMENT OF OCULAR DISORDERS 审中-公开缺氧诱导因子1与相关应用眼部疾病治疗的调节剂
公开(公告)号：EP1928470A4
公开(公告)日：2010-09-15
申请号：EP06789280
申请日：2006-08-01
发明人： KHODADOUST MEHRAN , SHARMA AJAY
CPC分类号： A61K31/704 , A61K31/7048 , A61K39/395 , A61K2300/00
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3.发明公开COMBINATORIAL CHEMOTHERAPY TREATMENT USING NA+/K+-ATPASE INHIBITORS 审中-公开组合化学疗法治疗用Na + / K + -ATP酶抑制剂的
公开(公告)号：EP1789090A2
公开(公告)日：2007-05-30
申请号：EP05796380.3
申请日：2005-09-02
发明人： KHODADOUST, Mehran , SHARMA, Ajay
IPC分类号： A61K45/06
CPC分类号： A61K45/06 , A61K31/585 , A61K2300/00
摘要： The reagent, pharmaceutical formulation, kit, and methods of the invention provides a new approach to alleviate or eliminate certain negative effects associated with the use of certain cancer treatment agents (e.g. chemotherapy therapeutics, etc.) or regimens (e.g. radio therapies, etc.) including stimulation of the hypoxic stress response in tumor cells.
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4.发明公开
公开(公告)号：EP1786440A2
公开(公告)日：2007-05-23
申请号：EP05796526.1
申请日：2005-09-02
发明人： KHODADOUST, Mehran , SHARMA, Ajay
IPC分类号： A61K31/7048
CPC分类号： A61K31/395 , A61K31/17 , A61K31/365 , A61K31/407 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/70 , A61K31/7048 , A61K31/7068 , A61K31/7072 , A61K33/24 , A61K39/39541 , A61K2300/00
摘要： The reagent, pharmaceutical formulation, kit, and methods of the invention provides a new approach to treat refractory cancers using Na+/K+-ATPase inhibitors, such as cardiac glycosides (e.g. ouabain or proscillaridin, etc.).
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5.发明公开MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES FOR THE TREATMENT OF OCULAR DISORDERS 审中-公开缺氧诱导因子1与相关应用眼部疾病治疗的调节剂
公开(公告)号：EP1928470A2
公开(公告)日：2008-06-11
申请号：EP06789280.2
申请日：2006-08-01
发明人： KHODADOUST, Mehran , SHARMA, Ajay
IPC分类号： A61K31/58 , A61K31/585 , C07J17/00 , C07J41/00
CPC分类号： A61K31/704 , A61K31/7048 , A61K39/395 , A61K2300/00
摘要： Methods for treatment of ocular disorders using steroids modulate the effects of local and systemic hypoxic events mediated by hypoxia inducible factor- 1 (HIF-1). Steroids that are useful as HIF-1 modulators include bufalin, digitoxigenin, digoxin, lanatoside C, strophantin K, uzarigenin, ouabain and proscillaridin. In some embodiments the ocular disorder is characterized by ischmia.
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公开(公告)号：EP1796688A1
公开(公告)日：2007-06-20
申请号：EP05794315.1
申请日：2005-09-02
发明人： KHODADOUST, Mehran , SHARMA, Ajay
IPC分类号： A61K31/704
CPC分类号： A61K31/704
摘要： The reagent, pharmaceutical formulation, kit, and methods of the invention provides a new approach for treating pancreatic cancers. The invention provides the use of Na+/K+-ATPase inhibitors, such as cardiac glycosides (e.g. ouabain and proscillaridin, etc.), either alone or in combination with other standard therapeutic agents (chemo- or radio-therapies, etc.) for treating pancreatic cancers.
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7.发明公开COMPOSITIONS AND METHODS FOR THE DISCOVERY AND SELECTION OF BIOLOGICAL INFORMATION 审中-公开组合物以及用于发现和选择生物信息方法
公开(公告)号：EP1246946A4
公开(公告)日：2003-05-28
申请号：EP01984619
申请日：2001-10-26
发明人： KHODADOUST MEHRAN M
IPC分类号： G01N33/50 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07H21/04 , C12N20060101 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/08 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/11 , C12N15/74 , C12N15/85 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C12N15/85 , C12N2800/30 , C12N2800/60 , C12N2830/003 , C12N2840/206 , C12N2840/44 , C12Q1/6897
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8.发明公开COMPOSITIONS AND METHODS FOR THE DISCOVERY AND SELECTION OF BIOLOGICAL INFORMATION 审中-公开组合物以及用于发现和选择生物信息方法
公开(公告)号：EP1246946A2
公开(公告)日：2002-10-09
申请号：EP01984619.5
申请日：2001-10-26
CPC分类号： C12N15/85 , C12N2800/30 , C12N2800/60 , C12N2830/003 , C12N2840/206 , C12N2840/44 , C12Q1/6897
摘要： Methods and vectors are disclosed for discovering intracellular regulatory pathways utilized by specific stimulatory agents. Suitable stimulatory agents include cytokines, chemical agents, and antibodies. Cell lines and regulatory factors are provided for screening libraries of drug candidates to identify potential therapeutic agents. Methods and compositions are also provided for identifying genes which are necessary for, or capable of, up regulating or down regulating the targeted genomic loci in the selected cells.
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