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    CHROMATIN SEGMENTATION
    1.
    发明公开
    CHROMATIN SEGMENTATION 审中-公开
    CHROMATINSEGMENTIERUNG

    公开(公告)号：EP1433140A4

    公开(公告)日：2009-03-18

    申请号：EP02750643

    申请日：2002-07-19

    申请人： UNIV ADELAIDE ,  UNIV SOUTH AUSTRALIA ,  UNIV MELBOURNE ,  UNIV FLINDERS ,  UNIV QUEENSLAND ,  COMMW OF AUSTRALIA REPRESENTED ,  TELSTRA CORP LTD ,  COMPAQ COMP AUSTRALIA PTY LTD ,  RLM SYSTEMS PTY LTD ,  CEA TECHNOLOGIES INC

    发明人： JACKWAY PAUL ,  MEHNERT ANDREW

    IPC分类号： G06T5/00 ,  G06T5/20 ,  G06T7/40 ,  G06K9/00

    CPC分类号： G06K9/0014 ,  G06T5/20 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/155 ,  G06T2207/10056 ,  G06T2207/30024

    摘要： A method of segmenting chromatin particles in a nucleus of a cell by locating regional minima in an image, computing a zone of influence (ZOI) around each regional minimum, and segmenting a single chromatin blob within each ZOI using a region growing procedure. The method can be used as the basis of a method of qualitatively characterizing the distribution of nuclear chromatin by computing features for individual chromatin particles. Chromatin features can be synthesized from the features of individual particles and particle features can be synthesized into nucleus features and slide features. The method is useful for detecting malignancy associated changes and changes during neoplasia. The method may also be used more generally to assess chromatin patterns in living cells during the cell life cycle. This makes it possible to measure alternations in the evolving patterns that result from pathological or environmental influences.

    摘要翻译： 通过在图像中定位区域最小值，计算每个区域最小值周围的影响区域（ZOI），并且使用区域生长程序分割每个ZOI内的单个染色质斑点，来细分细胞核中的染色质颗粒的方法。 该方法可用作通过计算单个染色质颗粒的特征来定性表征核染色质分布的方法的基础。 染色质特征可以从个体颗粒的特征合成，并且颗粒特征可以合成为核特征和幻灯片特征。 该方法可用于检测瘤形成期间恶性肿瘤相关的变化和变化。 该方法也可以更一般地用于评估细胞生命周期中活细胞中的染色质模式。 这使得可以测量由病理或环境影响导致的演变模式的变化。

    CHROMATIN SEGMENTATION
    3.
    发明公开
    CHROMATIN SEGMENTATION 审中-公开
    色素分割

    公开(公告)号：EP1433140A1

    公开(公告)日：2004-06-30

    申请号：EP02750643.5

    申请日：2002-07-19

    申请人： The University of Adelaide ,  UNIVERSITY OF SOUTH AUSTRALIA ,  The University of Melbourne ,  Flinders University ,  The University of Queensland ,  The Commonwealth of Australia Represented by DSTO ,  Telstra Corporation Limited ,  Compaq Computer Australia Pty Ltd ,  RLM Systems Pty Ltd ,  CEA Technologies Inc.

    发明人： JACKWAY, Paul ,  MEHNERT, Andrew,University of Queensland

    IPC分类号： G06T7/40 ,  G06K9/00

    CPC分类号： G06K9/0014 ,  G06T5/20 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/155 ,  G06T2207/10056 ,  G06T2207/30024

    摘要： A method of segmenting chromatin particles in a nucleus of a cell by locating regional minima in an image, computing a zone of influence (ZOI) around each regional minimum, and segmenting a single chromatin blob within each ZOI using a region growing procedure. The method can be used as the basis of a method of qualitatively characterizing the distribution of nuclear chromatin by computing features for individual chromatin particles. Chromatin features can be synthesized from the features of individual particles and particle features can be synthesized into nucleus features and slide features. The method is useful for detecting malignancy associated changes and changes during neoplasia. The method may also be used more generally to assess chromatin patterns in living cells during the cell life cycle. This makes it possible to measure alternations in the evolving patterns that result from pathological or environmental influences.

    摘要翻译： 通过在图像中定位区域最小值，计算每个区域最小值周围的影响区域（ZOI），并且使用区域生长程序分割每个ZOI内的单个染色质斑点，来细分细胞核中的染色质颗粒的方法。 该方法可用作通过计算单个染色质颗粒的特征来定性表征核染色质分布的方法的基础。 染色质特征可以从个体颗粒的特征合成，并且颗粒特征可以合成为核特征和幻灯片特征。 该方法可用于检测瘤形成期间恶性肿瘤相关的变化和变化。 该方法也可以更一般地用于评估细胞生命周期中活细胞中的染色质模式。 这使得可以测量由病理或环境影响导致的演变模式的变化。