公开(公告)号：EP1088285B1

公开(公告)日：2004-12-15

申请号：EP99912984.4

申请日：1999-03-30

申请人： The University of Adelaide ,  UNIVERSITY OF SOUTH AUSTRALIA ,  THE UNIVERSITY OF QUEENSLAND ,  The University of Melbourne ,  Compaq Computer Australia Pty Ltd ,  Telstra Corporation Limited ,  RLM Systems Pty Ltd ,  Flinders University ,  CEA Technologies Pty Limited ,  The Commonwealth of Australia Represented by DSTO

发明人： BAMFORD, Pascal ,  LOVELL, Brian

IPC分类号： G06T7/60 ,  G06F19/00 ,  G06K9/00 ,  G06K9/48

CPC分类号： G06K9/0014 ,  G06K9/6207 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/143 ,  G06T7/149 ,  G06T2207/10056 ,  G06T2207/30012 ,  G06T2207/30024

公开(公告)号：EP1433140A1

公开(公告)日：2004-06-30

申请号：EP02750643.5

申请日：2002-07-19

申请人： The University of Adelaide ,  UNIVERSITY OF SOUTH AUSTRALIA ,  The University of Melbourne ,  Flinders University ,  The University of Queensland ,  The Commonwealth of Australia Represented by DSTO ,  Telstra Corporation Limited ,  Compaq Computer Australia Pty Ltd ,  RLM Systems Pty Ltd ,  CEA Technologies Inc.

发明人： JACKWAY, Paul ,  MEHNERT, Andrew,University of Queensland

IPC分类号： G06T7/40 ,  G06K9/00

CPC分类号： G06K9/0014 ,  G06T5/20 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/155 ,  G06T2207/10056 ,  G06T2207/30024

摘要： A method of segmenting chromatin particles in a nucleus of a cell by locating regional minima in an image, computing a zone of influence (ZOI) around each regional minimum, and segmenting a single chromatin blob within each ZOI using a region growing procedure. The method can be used as the basis of a method of qualitatively characterizing the distribution of nuclear chromatin by computing features for individual chromatin particles. Chromatin features can be synthesized from the features of individual particles and particle features can be synthesized into nucleus features and slide features. The method is useful for detecting malignancy associated changes and changes during neoplasia. The method may also be used more generally to assess chromatin patterns in living cells during the cell life cycle. This makes it possible to measure alternations in the evolving patterns that result from pathological or environmental influences.

摘要翻译： 通过在图像中定位区域最小值，计算每个区域最小值周围的影响区域（ZOI），并且使用区域生长程序分割每个ZOI内的单个染色质斑点，来细分细胞核中的染色质颗粒的方法。 该方法可用作通过计算单个染色质颗粒的特征来定性表征核染色质分布的方法的基础。 染色质特征可以从个体颗粒的特征合成，并且颗粒特征可以合成为核特征和幻灯片特征。 该方法可用于检测瘤形成期间恶性肿瘤相关的变化和变化。 该方法也可以更一般地用于评估细胞生命周期中活细胞中的染色质模式。 这使得可以测量由病理或环境影响导致的演变模式的变化。

公开(公告)号：EP1088285A1

公开(公告)日：2001-04-04

申请号：EP99912984.4

申请日：1999-03-30

申请人： Spire Technologies Pty Ltd. ,  The University of Adelaide ,  UNIVERSITY OF SOUTH AUSTRALIA ,  THE UNIVERSITY OF QUEENSLAND ,  The University of Melbourne ,  Compaq Computer Australia Pty Ltd ,  Telstra Corporation Limited ,  RLM Systems Pty Ltd ,  Flinders University ,  CEA Technologies Pty Limited ,  The Commonwealth of Australia Represented by DSTO

发明人： BAMFORD, Pascal ,  LOVELL, Brian

IPC分类号： G06T7/60 ,  G06F19/00

CPC分类号： G06K9/0014 ,  G06K9/6207 ,  G06T7/0012 ,  G06T7/12 ,  G06T7/143 ,  G06T7/149 ,  G06T2207/10056 ,  G06T2207/30012 ,  G06T2207/30024

摘要： A method of segmentation of cell nuclei is described that uses an active contours approach based on a Viterbi search algorithm. Also disclosed is an initialisation technique that maximises the probability of a correct segmentation. The invention also includes a method to classify cell nuclei according to the difficulty of correct segmentation. Nuclei that are difficult to segment can be rejected to minimise the probability of false positives. The probability of false positives can be driven close to 0 %.

摘要翻译： 描述了使用基于维特比搜索算法的主动轮廓方法的细胞核分割方法。 还公开了使正确分割的概率最大化的初始化技术。 本发明还包括根据正确分割的难度对细胞核进行分类的方法。 难以分裂的核可以被拒绝以最小化误报的可能性。 假阳性的概率可以接近0％。

公开(公告)号：EP1309944B1

公开(公告)日：2009-12-16

申请号：EP01944759.8

申请日：2001-06-28

申请人： University of Adelaide ,  Compaq Computer Australia Pty Ltd ,  RLM Systems Pty Ltd ,  CEA Technologies Inc. ,  The Commonwealth of Australia Represented by DSTO ,  UNIVERSITY OF SOUTH AUSTRALIA

发明人： JACKWAY, Paul, University of Queensland ,  BAMFORD, Pascal University of Queensland

IPC分类号： G06T7/00

CPC分类号： G06K9/00134 ,  G06T7/11 ,  G06T7/155 ,  G06T2207/10056 ,  G06T2207/20152 ,  G06T2207/30024

摘要： A method of segmenting objects in an image is described. The method applies a Top Hat algorithm to the image then constructs inner and outer markers for application to the original image in a Watershed algorithm. The inner marker is constructed using binary erosion. The outer marker is constructed using binary dilation and perimeterisation. The method finds particular application for first level segmentation of a cell nucleus prior to detailed analysis.

公开(公告)号：EP1171845B1

公开(公告)日：2007-05-02

申请号：EP00906078.1

申请日：2000-03-01

申请人： The University of Adelaide ,  UNIVERSITY OF SOUTH AUSTRALIA ,  The University of Melbourne ,  Flinders University ,  THE UNIVERSITY OF QUEENSLAND ,  COMMONWEALTH OF AUSTRALIA ,  TELSTRA CORPORATION LIMITED ,  Compaq Computer Australia Pty Ltd ,  RLM Systems Pty Ltd ,  CEA Technologies Inc.

发明人： JACKWAY, Paul ,  JONES, Damian

IPC分类号： G06T7/40

CPC分类号： G06T7/44

摘要： A method and apparatus for image texture analysis in which the image is mapped into a first set of binary representation by a monotonically varying operator, such as a threshold operator. Each binary representation in the first set of binary representations is mapped to a further set of binary representations using a second monotonically varying operator, such as a spatial operator. The result of the two mappings is a matrix of binary image representations. Each binary image representation is allocated a scalar value to form an array of scalar values which may be analysed to identify defined texture characteristics.

摘要翻译： 一种用于图像纹理分析的方法和装置，其中通过单调变化的运算符（诸如阈值运算符）将图像映射到第二组二进制表示。 第二组二进制表示中的每个二进制表示使用第二单调变化运算符（例如空间运算符）映射到另一组二进制表示。 两个映射的结果是二进制图像表示的矩阵。 每个二进制图像表示被分配标量值以形成标量值的数组，其可以被分析以识别定义的纹理特征。

公开(公告)号：EP1171845A1

公开(公告)日：2002-01-16

申请号：EP00906078.1

申请日：2000-03-01

申请人： The University of Adelaide ,  UNIVERSITY OF SOUTH AUSTRALIA ,  The University of Melbourne ,  Flinders University ,  THE UNIVERSITY OF QUEENSLAND ,  Commonwealth of Australia ,  Telstra Corporation Limited ,  Compaq Computer Australia Pty Ltd ,  RLM Systems Pty Ltd ,  CEA Technologies Inc.

发明人： JACKWAY, Paul ,  JONES, Damian

IPC分类号： G06T7/40

CPC分类号： G06T7/44

摘要： A method and apparatus for image texture analysis in which the image is mapped into a first set of binary representation by a monotonically varying operator, such as a threshold operator. Each binary representation in the first set of binary representations is mapped to a further set of binary representations using a second monotonically varying operator, such as a spatial operator. The result of the two mappings is a matrix of binary image representations. Each binary image representation is allocated a scalar value to form an array of scalar values which may be analysed to identify defined texture characteristics.

公开(公告)号：EP1309944A1

公开(公告)日：2003-05-14

申请号：EP01944759.8

申请日：2001-06-28

申请人： University of Adelaide ,  Compaq Computer Australia Pty Ltd ,  RLM Systems Pty Ltd ,  CEA Technologies Inc. ,  The Commonwealth of Australia Represented by DSTO ,  UNIVERSITY OF SOUTH AUSTRALIA

发明人： JACKWAY, Paul,University of Queensland ,  BAMFORD, PascalUniversity of Queensland

IPC分类号： G06T7/00

CPC分类号： G06K9/00134 ,  G06T7/11 ,  G06T7/155 ,  G06T2207/10056 ,  G06T2207/20152 ,  G06T2207/30024

摘要： A method of segmenting objects in an image is described. The method applies a Top Hat algorithm to the image then constructs inner and outer markers for application to the original image in a Watershed algorithm. The inner marker is constructed using binary erosion. The outer marker is constructed using binary dilation and perimeterisation. The method finds particular application for first level segmentation of a cell nucleus prior to detailed analysis.

摘要翻译： 描述了分割图像中的对象的方法。 该方法将Top Hat算法应用于图像，然后构建内部和外部标记，以便在Watershed算法中应用于原始图像。 内部标记是使用二元侵蚀构建的。 外部标记是使用二元扩张和周边化构建的。 该方法在详细分析之前对细胞核的一级分割具有特殊应用。