公开(公告)号：EP2735616A4

公开(公告)日：2015-05-20

申请号：EP12802461

申请日：2012-06-12

申请人： CALPIS CO LTD

发明人： UCHIDA NAOTO ,  GOTO HIROAKI ,  OHSAWA KAZUHITO ,  OHKI KOHJI

IPC分类号： C12P21/02 ,  A23L1/305 ,  A61K38/00 ,  A61P25/28 ,  C07K7/08 ,  C07K14/47 ,  C12N1/20

CPC分类号： C07K14/4732 ,  A23L33/17 ,  A23L33/18 ,  A23L33/19 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C12P21/06

公开(公告)号：EP2789340A1

公开(公告)日：2014-10-15

申请号：EP12855562.0

申请日：2012-12-06

申请人： Calpis Co., Ltd.

发明人： The designation of the inventor has not yet been filed

IPC分类号： A61K35/74 ,  A23L1/30 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P43/00 ,  C12N1/20

CPC分类号： A61K35/747 ,  A23L2/52 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/05 ,  A23Y2220/37 ,  A61K35/745 ,  C12N1/20 ,  C12R1/225 ,  A23V2200/326 ,  A23V2200/328 ,  A23V2200/332

摘要： This invention provides the use of a microorganism capable of improving both lipid metabolism and sugar metabolism. Specifically, the invention relates to: a lipid metabolism and/or sugar metabolism improver comprising, as an active ingredient, a bacterial cell selected from bacteria belonging to the genus Lactobacillus and the genus Bifidobacterium, a treated product of the bacterial cell, or a mixture thereof, having dual-agonistic activities to peroxisome proliferator activated receptor (PPAR)α and peroxisome proliferator activated receptor (PPAR)γ; to a food or a beverage comprising the improver; and to a pharmaceutical composition comprising the improver.

摘要翻译： 本发明提供能够改善脂质代谢和糖代谢的微生物的用途。 具体而言，本发明涉及：脂质代谢和/或糖代谢改善剂，其包含选自属于乳杆菌属和双歧杆菌属的细菌的细菌细胞作为活性成分，细菌细胞的处理产物或混合物 其具有过氧化物酶体增殖物激活受体（PPAR）±和过氧化物酶体增殖物激活受体（PPAR）3的双重激动活性; 包括改良剂的食品或饮料; 以及包含改良剂的药物组合物。

公开(公告)号：EP2735616A1

公开(公告)日：2014-05-28

申请号：EP12802461.9

申请日：2012-06-12

申请人： Calpis Co., Ltd.

发明人： UCHIDA Naoto ,  GOTO Hiroaki ,  OHSAWA Kazuhito ,  OHKI Kohji

IPC分类号： C12P21/02 ,  A23L1/305 ,  C07K7/08 ,  C07K14/47 ,  C12N1/20 ,  A61K38/00 ,  A61P25/28

CPC分类号： C07K14/4732 ,  A23L33/17 ,  A23L33/18 ,  A23L33/19 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C12P21/06

摘要： The present invention provides a simple and efficient method for preparing safer compounds which prevent and ameliorate conditions and diseases caused by reduction in brain function and are suitable for use in medicines and food products. Specifically, the present invention provides: a method for preparing peptides each consisting of an amino acid sequence shown in any of SEQ ID NOs: 1-4 or 16, said method being characterized in that mammalian milk or milk protein is fermented using at least one lactic acid bacterium and/or a processed product thereof, and then the peptides are collected from the resultant fermented milk.

摘要翻译： 本发明提供了一种制备更安全化合物的简单而有效的方法，其预防和改善由脑功能降低引起的病症和疾病，并且适用于药物和食品。 具体地说，本发明提供了一种肽的制备方法，其各自由SEQ ID NO：1-4或16中任一项所示的氨基酸序列组成，所述方法的特征在于，哺乳动物乳或乳蛋白使用至少一种 乳酸菌和/或其加工产物，然后从所得发酵乳中收集肽。

公开(公告)号：EP2130546B1

公开(公告)日：2013-02-27

申请号：EP08722459.8

申请日：2008-03-19

申请人： Calpis Co., Ltd.

发明人： HIROTA, Tatsuhiko ,  OHKI, Kohji ,  NAKAMURA, Teppei ,  TAKANO, Toshiaki

IPC分类号： A61K38/00 ,  A61K38/06 ,  A23L1/305 ,  A61P9/00 ,  A61P9/04

CPC分类号： A61K38/06 ,  A23L33/18 ,  A23V2002/00 ,  A23V2200/326 ,  A23V2250/0654 ,  A23V2250/064 ,  A23V2200/32 ,  A23V2250/0626

公开(公告)号：EP2338503B1

公开(公告)日：2012-08-22

申请号：EP10252062.4

申请日：2010-12-06

申请人： Calpis Co., Ltd.

发明人： Ohsawa, Kazuhito ,  Uchida, Naoto ,  Ohki, Kohji

IPC分类号： A61K38/10 ,  A61K38/17 ,  A61P25/28

CPC分类号： A61K38/10 ,  A61K38/1703 ,  C07K7/08

公开(公告)号：EP2123291B1

公开(公告)日：2012-05-30

申请号：EP07850807.4

申请日：2007-12-18

申请人： Calpis Co., Ltd.

发明人： HACHIMURA, Satoshi ,  KANZATO, Hiroki ,  FUJIWARA, Shigeru

IPC分类号： A61K35/74 ,  A61P37/04 ,  C12N1/20 ,  A61P37/08 ,  A61P1/02

CPC分类号： C12R1/225 ,  A61K35/747 ,  C12N1/20

摘要： The present invention provides Lactobacillus bacteria which enhance the functional of Peyer's patch and promote IgA production and which have a characteristics of localizing on human intestine as well as an agent for promoting IgA production. The present invention is directed to an agent for promoting IgA production containing Lactobacillus amylovorus cells, especially Lactobacillus amylovorus CP1750 (FERM BP-10532) as an active ingredient,

公开(公告)号：EP1698320B1

公开(公告)日：2011-02-09

申请号：EP04807687.1

申请日：2004-12-24

申请人： Calpis Co., Ltd.

发明人： YOSIMURA, Chiaki Calpis Co., Ltd. ,  MASUYAMA, Akihiro Calpis Co., Ltd.

IPC分类号： A61K8/98 ,  A61K35/20 ,  A61K35/74 ,  A61P17/16 ,  A23C21/02 ,  A23L1/30

CPC分类号： A61K35/20 ,  A23C21/026 ,  A23L33/19 ,  A23V2002/00 ,  A23Y2220/39 ,  A61K8/986 ,  A61K2800/85 ,  A61K2800/92 ,  A61Q19/00 ,  A23V2200/318 ,  A23V2250/54252

摘要： It is intended to provide functional foods and drinks which can exhibit an effect of moisturizing the skin when orally taken, have a high safety and can be continuously taken; a skin moisturizing agent to be used in these functional foods and drinks and so on; and utilization of the same. Namely, a skin moisturizing agent containing fermented milk whey, which is obtained by fermenting milk with the use of Lactobacillus helveticus, as the active ingredient;and functional foods and drinks containing the moisturizing agent and having an effect of moisturizing the skin.

公开(公告)号：EP1894478A4

公开(公告)日：2011-02-02

申请号：EP06766513

申请日：2006-06-09

申请人： CALPIS CO LTD

发明人： SHINOZAKI SATOSHI ,  HIGUCHI TOSHIMASA ,  ISHIKAWA RYOKO

IPC分类号： A23L2/44 ,  A23L1/302 ,  A23L1/305

CPC分类号： A23L2/66 ,  A23L2/44 ,  A23L2/52 ,  A23L2/68 ,  A23L33/15 ,  A23L33/175 ,  A23L33/18 ,  A23V2002/00 ,  A23V2250/7044 ,  A23V2250/708 ,  A23V2250/06 ,  A23V2250/54246

公开(公告)号：EP1142481B2

公开(公告)日：2009-09-02

申请号：EP00900164.5

申请日：2000-01-11

申请人： Calpis Co., Ltd.

发明人： KITAMURA, Shuji ,  UEYAMA, Takashi

IPC分类号： A23C9/123 ,  A23C20/02 ,  A23C11/10 ,  A23C21/02

CPC分类号： A23C21/026 ,  A23C9/123 ,  A23C9/1234 ,  A23C19/045 ,  A23C19/05 ,  A23C21/00 ,  A23C2260/05 ,  A23L33/18 ,  A23V2002/00 ,  A23Y2220/39 ,  A23V2200/326 ,  A23V2250/5424

摘要： Processes for producing fermented milk and milk serum whereby fermented milk and milk serum containing an ACEI peptide at a high content, which have high safety and are usable as drugs, funtional foods, health foods, etc., can be efficiently obtained at a high yield. A process for preparing fermented milk containing curd pieces and milk serum containing an angiotensin converting enzyme inhibitory peptide which involves the step of mixing and stirring a milk-containing material with lactic acid bacteria to give a mixed material, and the step of fermenting the mixed material under stirring so as to form the milk serum containing the angiotensin converting enzyme inhibitory peptide; and a process for producing milk serum further involving the step of centrifuging and/or compression-filtering the fermented milk obtained above to thereby separate and collect the milk serum.

公开(公告)号：EP1354592B1

公开(公告)日：2008-06-25

申请号：EP01994994.0

申请日：2001-12-25

申请人： Calpis Co., Ltd.

发明人： YAMAMOTO, Naoyuki Calpis Co., Ltd. ,  MASUDA, Osamu c/o Calpis Co., Ltd. ,  KANEKO, Kyoko c/o Calpis Co., Ltd. ,  IKEDA, Nagisa Calpis Co., Ltd. ,  ISHIDA, Yuu Calpis Co., Ltd. ,  KUSUDA, Daisuke c/o Calpis Co., Ltd. ,  SHINODA, Tadashi Calpis Co., Ltd.

IPC分类号： A61K35/74 ,  A61P1/14

CPC分类号： A61K35/20 ,  A61K35/747 ,  Y10S514/892 ,  A61K2300/00

摘要： Medicines for relieving intestinal disorders which contain viable cells of a strain belonging to Lactobacillus helveticus. This strain is preferably characterized by a resistance to a specific bile acid, adhesiveness to intestinal epithelial cells, etc. A method of controlling intestinal functions which involves the step of administering such a medicine to a subject with a need for the control of intestinal functions. When administered to humans or the like, these medicines exert effects of elevating stool frequency, etc., thereby efficaciously improving the intestinal environment.