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    METAL ION SENSORS AND METHODS OF DETECTING METAL IONS
    1.
    发明公开
    METAL ION SENSORS AND METHODS OF DETECTING METAL IONS 有权
    METALLIONENSENSOREN UND VERFAHREN ZUR DETEKTION VON METALLIONEN

    公开(公告)号：EP3030898A4

    公开(公告)日：2017-03-29

    申请号：EP14834333

    申请日：2014-08-06

    申请人： UNIV GEORGIA STATE RES FOUND INC

    发明人： YANG JENNY JIE ,  TANG SHEN ,  ZHUO YOU JOY

    IPC分类号： G01N33/20 ,  C07K16/18 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/52 ,  G01N33/58 ,  G01N33/68

    CPC分类号： G01N33/84 ,  C07K14/43595 ,  C07K14/4728 ,  C07K2319/04 ,  C07K2319/60 ,  G01N21/6428 ,  G01N33/582 ,  G01N2021/6441

    摘要： A method for constructing an metal ion binding motif by identifying an metal ion binding peptide that binds an metal ion with specificity, ascertaining at least a portion of a nucleic acid sequence encoding the metal ion binding peptide, tailoring the nucleic acid sequence encoding the metal ion binding peptide into an metal ion binding site, identifying a host protein and a relevant portion of the nucleic acid sequence of the host protein, operatively linking the tailored nucleic acid sequence encoding the metal ion binding peptide and the host protein nucleic acid sequence into an metal ion binding motif sequence, and expressing metal ion binding motif sequence, in which the nucleic acid sequence encoding the metal ion binding peptide is tailored so as to achieve the metal ion binding motif with a desired specificity for the metal ion. Also, the proteins encoded by the metal ion binding motif sequence as constructed by the method.

    摘要翻译： 一种金属离子结合基序的构建方法，通过鉴定金属离子结合肽，其特异性结合金属离子，确定至少一部分编码金属离子结合肽的核酸序列，调节编码金属离子的核酸序列 将结合肽结合到金属离子结合位点，鉴定宿主蛋白和宿主蛋白的核酸序列的相关部分，将编码金属离子结合肽的定制核酸序列与宿主蛋白核酸序列可操作地连接到金属 离子结合基序序列和表达金属离子结合基序序列，其中编码金属离子结合肽的核酸序列被定制以便实现具有金属离子所需特异性的金属离子结合基序。 此外，由该方法构建的由金属离子结合基序序列编码的蛋白质。

    CARBOCYANINES FOR G-QUADRUPLEX DNA STABILIZATION AND TELOMERASE INHIBITION
    5.
    发明公开
    CARBOCYANINES FOR G-QUADRUPLEX DNA STABILIZATION AND TELOMERASE INHIBITION 审中-公开
    用于G-四聚体DNA稳定化和端粒酶抑制的羰基

    公开(公告)号：EP2734645A4

    公开(公告)日：2014-12-17

    申请号：EP12815580

    申请日：2012-07-18

    申请人： UNIV GEORGIA STATE RES FOUND

    发明人： HENARY MAGED ,  WILSON W DAVID

    IPC分类号： C12Q1/68

    CPC分类号： C09B23/06 ,  C07D209/14 ,  C07D403/06

    摘要： Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.

    摘要翻译： 本文描述了选择性结合G-四链体DNA复合物，特别是在癌细胞中表达的四链体的花青苷及其制备和使用方法。 花青可以是对称或不对称的链花青，半花青，闭环花青或其组合。 花青优选被一个或多个使花青聚集和/或抑制花青与双链DNA结合的聚集或阻止聚集的基团取代。 一种或多种花青可以与一种或多种药物赋形剂和/或载体一起配制，以制备适于给予患者，特别是人类患者的药物组合物。 本文所述的化合物和组合物可用于治疗特征在于表达G-四链体DNA（例如癌症）的疾病或病症。

    METHODS OF INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA AND COMPOUNDS USEFUL THEREFOR
    10.
    发明公开
    METHODS OF INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA AND COMPOUNDS USEFUL THEREFOR 失效
    治疗PNEUMOCYTIS卡里尼方法会造成肺炎和合适的连接

    公开(公告)号：EP0831813A4

    公开(公告)日：2001-09-19

    申请号：EP96919040

    申请日：1996-06-03

    申请人： UNIV NORTH CAROLINA ,  UNIV GEORGIA STATE RES FOUND

    发明人： TIDWELL RICHARD R ,  HALL JAMES E ,  BOYKIN DAVID W

    IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/505 ,  A61P11/00 ,  A61P31/00 ,  C07D209/86 ,  C07D209/88 ,  C07D403/14

    CPC分类号： C07D403/14 ,  A61K31/403 ,  A61K31/4178 ,  C07D209/88

    摘要： The present invention provides methods for treating Pneumocystis carinii pneumonia. The method comprises administering to the subject a compound of Formula I: (I) wherein: X is located in the para or meta positions and is loweralkyl, loweralkoxy, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, alkylaryl, halogen, or wherein: each R2 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl or two R2 groups together represent C2-C10 alkylene, or two R2 groups together represent wherein m is from 1-3 and R4 is H, or -CONHR5NR6R7, wherein R5 is loweralkyl, R6 and R7 are each independently selected from the group consisting of H and lower alkyl; each R8 is independently selected from the group consisting of H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl, or two R8 groups together represent C2-C10 alkylene; R9 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl; R3 is H, hydroxy, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, or alkylaryl; R1 is H, loweralkyl, alkoxyalkyl, hydroxyalkyl, aminoalkyl, alkylaminoalkyl, cycloalkyl, aryl, alkylaryl, or halogen; or a pharmaceutically acceptable salt thereof.