公开(公告)号：EP2968575A1

公开(公告)日：2016-01-20

申请号：EP14717377.7

申请日：2014-03-17

申请人： Dr. Reddy's Laboratories Ltd. ,  Okumu, Franklin ,  Chen, Andrew X. ,  Chen, Hailiang

发明人： OKUMU, Franklin ,  CHEN, Andrew X. ,  CHEN, Hailiang

IPC分类号： A61K47/24 ,  A61K9/107 ,  A61K31/196

CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K31/196 ,  A61K45/06 ,  A61K47/24 ,  A61K47/26 ,  A61K47/44 ,  A61K2300/00

摘要： The present application provides parenteral compositions of diclofenac or its pharmaceutically acceptable salt and methods for making and using such compositions. Some of the compositions of the present application has one or more following properties: (1) ready to be injectable, (2) in the form of an oil-water emulsion, (3) stable under appropriate storage conditions, (4) containing therapeutically effective amount of diclofenac or its pharmaceutically acceptable salt, (5) sterilizable by filtration (6) containing components acceptable by regulatory agencies (e.g. the FDA), (7) containing low oil content and thus not exacerbating hyperlipidemia, and (8) is neither hypoallergenic nor vein irritating.

公开(公告)号：EP3104840A1

公开(公告)日：2016-12-21

申请号：EP15706617.6

申请日：2015-02-11

申请人： Dr. Reddy's Laboratories Ltd. ,  Okumu, Franklin ,  Chu, Jan-jon ,  Webb, Julie Ann ,  Sabino, Rafael Anthony ,  Chen, Andrew X.

发明人： OKUMU, Franklin ,  CHU, Jan-Jon ,  WEBB, Julie Ann ,  SABINO, Rafael Anthony ,  CHEN, Andrew Xian

IPC分类号： A61K9/107 ,  A61K31/415

CPC分类号： A61K31/635 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/1075 ,  A61K31/415 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/44

摘要： Parenteral (injectable) celecoxib emulsions and nanoemulsions are disclosed as are their use to treat pain in patients so afflicted. The emulsions are generally oil in water emulsions often comprised of an oil phase including an oil and a lecithin wherein the mean droplet size of the discontinuous oil phase is about 200 nanometers or less.