公开(公告)号：EP2968575A1

公开(公告)日：2016-01-20

申请号：EP14717377.7

申请日：2014-03-17

申请人： Dr. Reddy's Laboratories Ltd. ,  Okumu, Franklin ,  Chen, Andrew X. ,  Chen, Hailiang

发明人： OKUMU, Franklin ,  CHEN, Andrew X. ,  CHEN, Hailiang

IPC分类号： A61K47/24 ,  A61K9/107 ,  A61K31/196

CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K31/196 ,  A61K45/06 ,  A61K47/24 ,  A61K47/26 ,  A61K47/44 ,  A61K2300/00

摘要： The present application provides parenteral compositions of diclofenac or its pharmaceutically acceptable salt and methods for making and using such compositions. Some of the compositions of the present application has one or more following properties: (1) ready to be injectable, (2) in the form of an oil-water emulsion, (3) stable under appropriate storage conditions, (4) containing therapeutically effective amount of diclofenac or its pharmaceutically acceptable salt, (5) sterilizable by filtration (6) containing components acceptable by regulatory agencies (e.g. the FDA), (7) containing low oil content and thus not exacerbating hyperlipidemia, and (8) is neither hypoallergenic nor vein irritating.

公开(公告)号：EP2605751A1

公开(公告)日：2013-06-26

申请号：EP10795596.5

申请日：2010-12-17

申请人： Dr. Reddy's Laboratories, Ltd.

发明人： CHEN, Hailiang ,  CHEN, Andrew, Xian ,  SURAKANTI, Dushyanth ,  OKUMU, Franklin

IPC分类号： A61K9/00 ,  A61K9/107 ,  A61K9/14 ,  A61K9/16 ,  A61K31/7036 ,  A61K38/14

CPC分类号： A61K9/107 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/1075 ,  A61K9/145 ,  A61K9/16 ,  A61K9/1617 ,  A61K9/1682 ,  A61K31/7036 ,  A61K38/14 ,  A61K47/10 ,  A61K47/24 ,  A61K47/44

摘要： The present invention provides a clear depot comprising at least one hydrophilic water-soluble pharmaceutically active agent selected from the group consisting of vancomycin, gentamicin, a pharmaceutically acceptable salt thereof and a mixture thereof, water, a phospholipid, an oil, optionally a pH adjusting agent, and a viscosity modifying agent selected from the group consisting of ethanol, isopropanol, and a mixture thereof, wherein the water present in the depot is no more than about 4 wt % relative to the total weight of the depot and the depot has a pH of between about 3 and about 6, method of making and administering same.

摘要翻译： 本发明提供了包含至少一种选自万古霉素，庆大霉素，其药学上可接受的盐及其混合物，水，磷脂，油，任选的pH调节剂的亲水性水溶性药物活性剂的透明储库 试剂和选自乙醇，异丙醇及其混合物的粘度调节剂，其中储库中存在的水相对于储库和储库的总重量不大于约（4）wt％ 具有在约（3）和约（6）之间的pH，制备和施用它们的方法。