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公开(公告)号：EP1389445B1
公开(公告)日：2008-07-23
申请号：EP03255045.1
申请日：2003-08-14
IPC分类号： A61B10/00
CPC分类号： A61B10/0051 , A61B10/0045 , A61B10/0096
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公开(公告)号：EP1825262A1
公开(公告)日：2007-08-29
申请号：EP05754731.7
申请日：2005-07-01
CPC分类号： G01N33/5008 , G01N33/50 , G01N33/5038 , G01N33/526 , G01N33/94 , G01N33/948
摘要： The invention provides competitive immunoassay techniques for high sensitivity detection of delta-9-tetrahydrocannabinol (cannabis; THC) employing a carrier conjugate of an intermediate in the biosynthesis of cannabis, more particularly 5-pentylresorcinol conjugated to a macromolecular carrier via its hydroxyl groups. By employing such a conjugate with anti-THC antibody in a lateral flow immunochromtography test device convenient on-site testing for low levels of cannabis in liquid samples may be achieved. Such testing is particularly favoured for roadside testing for cannabis in oral fluid samples.
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公开(公告)号：EP1756575B1
公开(公告)日：2008-10-22
申请号：EP05748983.3
申请日：2005-06-10
IPC分类号： G01N33/558 , A61K47/48 , G01N33/94
CPC分类号： G01N33/558 , G01N33/946 , Y10S436/808 , Y10S436/81 , Y10S436/815 , Y10S436/816
摘要： The present invention provides immunoassays which are highly specific for detection in biological samples of methamphetamine and other drugs of abuse of the methamphetamine group such as ecstasy and other ecstasy class drugs. More particularly, competitive assays are provided comprising: (a) contacting said sample with (i) a pseudoephedrine/carrier conjugate in which pseudoephedrine is linked via its hydroxyl group to the carrier and (ii) an antibody which is capable of binding both one or more drugs of the methamphetamine group and said conjugate; and (b) determining whether the binding of said antibody to said conjugate is reduced by the presence of said sample, a reduction in binding being indicative that the sample contains a methamphetamine group drug.
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公开(公告)号：EP1825262B1
公开(公告)日：2008-09-17
申请号：EP05754731.7
申请日：2005-07-01
CPC分类号： G01N33/5008 , G01N33/50 , G01N33/5038 , G01N33/526 , G01N33/94 , G01N33/948
摘要： The invention provides competitive immunoassay techniques for high sensitivity detection of delta-9-tetrahydrocannabinol (cannabis; THC) employing a carrier conjugate of an intermediate in the biosynthesis of cannabis, more particularly 5-pentylresorcinol conjugated to a macromolecular carrier via its hydroxyl groups. By employing such a conjugate with anti-THC antibody in a lateral flow immunochromtography test device convenient on-site testing for low levels of cannabis in liquid samples may be achieved. Such testing is particularly favoured for roadside testing for cannabis in oral fluid samples.
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公开(公告)号：EP1095270B2
公开(公告)日：2010-11-24
申请号：EP99933037.6
申请日：1999-07-14
发明人： JONES, Osborn, P.-Snowdonia Busi. Inno. Cent. Lim. , SPIVEY, Robin, James-Cozart Bioscience Limited , HAND, Christopher, William-Cozart Bioscience Limit , BALDWIN, Dene-Cozart Bioscience Limited
CPC分类号： G01N33/54366 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805
摘要： Immunoassay tests run on samples of body fluid may be screened in the screening device and the lines formed by the immunoassay testing are interpreted to detect the presence of particular compounds such as drugs in the body. Light from an LED 44 is shone onto the window of an immunoassay test cartridge 10 illuminating a test membrane. Light reflected from the membrane 24 is reflected by a mirror 40 into the field of view of a charge coupled device 34. The image is digitised and outputted by video data interface to a CPU 80 for data processing. The digitised data is segmented according to preset data defining control regions test regions and background regions on the test membrane. The segmented data for the test region is compared to the data from the control region and the background regions to determine whether the test data exhibits any significant results compared to the control region and background regions. The results of the comparison are outputted to a liquid crystal display. The results may be displayed as either positive or negative for any particular substance or the concentration of the particular substance may be displayed. The screening device incorporates a timer which is activated when an immunoassay test cartridge is inserted into the device to ensure that an appropriate delay occurs to allow the immunoassay test to run correctly.
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公开(公告)号：EP1845857A1
公开(公告)日：2007-10-24
申请号：EP05818444.1
申请日：2005-12-13
IPC分类号： A61B10/00
CPC分类号： A61B10/0045 , A61B10/0051 , A61B10/0064
摘要： An analyte collection apparatus (1) is provided, comprising a gripper (3); and a compressible analyte collecting portion (5) releasably gripped (3) by the gripper (3), wherein the gripper exerts a force to grip and compress the analyte collecting portion (5). The analyte collecting portion (5) can be immersed in a buffer solution whilst in the partially compressed state, and allowed to expand therein, reducing the time required for non-specific binding of analytes to the analyte collecting portion. The analyte collection device (1) facilitates indirect handling of the collected analyte, preventing cross-contamination, and also allows for quick on-site testing.
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公开(公告)号：EP1389445A2
公开(公告)日：2004-02-18
申请号：EP03255045.1
申请日：2003-08-14
IPC分类号： A61B10/00
CPC分类号： A61B10/0051 , A61B10/0045 , A61B10/0096
摘要： An oral fluid collection and transfer device comprises a collection device (10) and a test cartridge (100). The collection device includes a frame or chassis (14), and an absorbing pad (12) for absorbing oral fluid and which is secured around part of the frame with part of the frame protruding from the pad. A collapsible cover (16) covers the absorbing means and has apertures (68) forthe ingress of oral fluid into contact with the absorbing pad. Acap (18) covers the part of the frame protruding from the absorbing pad. The cap and the cover latch together to surround the frame and the absorbing pad. The device also includes a fluid adequacy indicator (20) in the form of an electrical circuit with an LED (66) which is completed when the absorbing means has absorbed a predetermined volume of oral fluid. The test cartridge (100) has a collection chamber (110) to allow insertion of the collection device into the test cartridge. A test strip (150) is used to for test the oral fluid for the presence of analytes. The collection device (10) is located at a fixed location relative to the test cartridge (100) within the collection chamber(110), in which location the absorbing pad (12) undergoes a controlled degree of compression, thereby transferring a predetermined volume of oral fluid from the absorbing pad to the test strip. A transportation vial may also be provided for the secure transportation of a sample of oral fluid to a laboratory for test verification. After initial testing, the collection device (10) is inserted into a transportation vial (180) wherein the remaining oral fluid contained within the collection device (10) is transferred to a sample vial (190) containing a preservative substance to prevent degradation of the sample during transportation. The collection device (10) and transportation vial (180) are repackaged and sealed with a tamper proof seal before being returned to a laboratory for confirmation or further tests.
摘要翻译： 口腔液收集和转移装置包括收集装置（10）和测试盒（100）。 收集装置包括框架或底座（14）和用于吸收口腔流体的吸收垫（12），并且该吸收垫被固定在框架的一部分周围，其中框架的一部分从垫突出。 可折叠盖（16）覆盖吸收装置并且具有用于使口腔流体进入与吸收垫接触的孔（68）。 Acap（18）覆盖从吸收垫突出的框架部分。 盖子和盖子锁在一起以围绕框架和吸收垫。 该装置还包括具有LED（66）的电路形式的流体充足指示器（20），当吸收装置已经吸收了预定体积的口腔流体时，该LED（66）完成。 测试盒（100）具有收集室（110）以允许收集装置插入到测试盒中。 使用测试条（150）来测试口腔液体中是否存在分析物。 收集装置（10）位于收集腔室（110）内相对于测试盒（100）的固定位置处，吸收垫（12）经受受控程度的压缩，从而将预定体积的 从吸收垫到测试条的口液。 还可以提供运输小瓶用于将唾液样本安全运送到实验室进行测试验证。 在初始测试之后，将收集装置（10）插入运输小瓶（180）中，其中收集装置（10）内容纳的剩余口腔液被转移至含有防腐剂物质的样品瓶（190）以防止 运输过程中的样品 收集装置（10）和运输小瓶（180）在返回实验室进行确认或进一步测试之前，用防篡改密封件重新包装并密封。
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公开(公告)号：EP2408377A1
公开(公告)日：2012-01-25
申请号：EP10709208.2
申请日：2010-03-16
发明人： JOWETT, Gordon , WOODHEAD, Andrew
IPC分类号： A61B10/00
CPC分类号： A61B10/0051 , Y10T29/49826
摘要： According to a first aspect of the present invention there is provided an oral fluid collection device (1). The oral fluid collection device (1) comprises a handle (2), a swab holder (4), and a swab (3). The swab (3) is in the form of a hollow tube of absorbent material coaxially located about the swab holder (4), such that the swab (3) is supported by the swab holder (4) along the entire length of the swab (3).
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公开(公告)号：EP2181333A1
公开(公告)日：2010-05-05
申请号：EP08789360.8
申请日：2008-07-18
发明人： DE THEIJE, Femke, K. , VAN DER WIJK, Thea , IMMINK, Albert, H., J. , PELSSERS, Eduard, G., M. , HARDEMAN, Wilhelmina, M. , MARLIN, Sandra , JOWETT, Gordon, T.
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N27/745 , Y10T29/49885
摘要： A system and method is described wherein components of the reagent (4), e.g. labelled antibodies, are separated from the biologically active sensor surface (5) by depositing the reagent (4) on a carrier surface (3) distinct from the sensor surface (5) in the detection region (2), e.g. detection chamber. In this way, a high assay reproducibility is obtained. By allowing a short, well-defined and controlled, pre-incubation time between the particles of interest, e.g. drugs, in the sample fluid (20) and the reagent (4), the reproducibility will be increased, whereas the speed of the assay is guaranteed by having all components in one detection region (2), e.g. detection chamber.
摘要翻译： 描述了一种系统和方法，其中试剂（4）的组分例如。 通过将试剂（4）沉积在与检测区域（2）中的传感器表面（5）不同的载体表面（3）上，例如将标记的抗体与生物活性传感器表面（5）分离。 检测室。 以这种方式，可以获得高测定重现性。 通过允许感兴趣的颗粒之间的短的，明确的和受控的预孵育时间，例如， 药物在样品液体（20）和试剂（4）中的重现性将会增加，而测定速度则通过将检测区域（2）中的所有成分（例如， 检测室。
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公开(公告)号：EP1756575A2
公开(公告)日：2007-02-28
申请号：EP05748983.3
申请日：2005-06-10
IPC分类号： G01N33/558 , A61K47/48 , G01N33/94
CPC分类号： G01N33/558 , G01N33/946 , Y10S436/808 , Y10S436/81 , Y10S436/815 , Y10S436/816
摘要： The present invention provides immunoassays which are highly specific for detection in biological samples of methamphetamine and other drugs of abuse of the methamphetamine group such as ecstasy and other ecstasy class drugs. More particularly, competitive assays are provided comprising: (a) contacting said sample with (i) a pseudoephedrine/carrier conjugate in which pseudoephedrine is linked via its hydroxyl group to the carrier and (ii) an antibody which is capable of binding both one or more drugs of the methamphetamine group and said conjugate; and (b) determining whether the binding of said antibody to said conjugate is reduced by the presence of said sample, a reduction in binding being indicative that the sample contains a methamphetamine group drug.
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