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公开(公告)号:EP3565842A1
公开(公告)日:2019-11-13
申请号:EP18700245.6
申请日:2018-01-08
发明人: EDWARDS, Carolyn , LEGG, James , LEWANDOWSKA, Martyna , JOHNSTON, Colette , ROSSANT, Christine , TENG, Yumin
IPC分类号: C07K16/28
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2.
公开(公告)号:EP4259165A1
公开(公告)日:2023-10-18
申请号:EP21851973.4
申请日:2021-12-09
发明人: SHAPIRO, Gary , HE, Xingyue , NG, Mei, Rosa , THOMPSON, Lorraine , DE JUAN FRANCO, Elena , VANCE, Steven
IPC分类号: A61K35/17 , A61K39/00 , A61P35/00 , C07K14/725 , C07K16/40
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公开(公告)号:EP3969474A1
公开(公告)日:2022-03-23
申请号:EP20728166.8
申请日:2020-05-15
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公开(公告)号:EP3880703A1
公开(公告)日:2021-09-22
申请号:EP19809554.9
申请日:2019-11-13
发明人: EDWARDS, Bryan , PINTO, Debora
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公开(公告)号:EP3209698A1
公开(公告)日:2017-08-30
申请号:EP14790686.1
申请日:2014-10-22
CPC分类号: C07K16/00 , A01K67/0278 , A01K2217/052 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/46 , C07K2317/569 , C07K2317/92 , C12N15/8509 , C12N2800/206 , C12N2830/30
摘要: The invention relates to nucleic acid constructs for expression in mice for the production of heavy chain only antibodies and VH domains, transgenic mice, related methods and uses.
摘要翻译: 本发明涉及用于在小鼠中表达以产生仅有重链的抗体和VH结构域的核酸构建体,转基因小鼠,相关方法和用途。
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公开(公告)号:EP3710478A1
公开(公告)日:2020-09-23
申请号:EP18808058.4
申请日:2018-11-13
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公开(公告)号:EP3402825A1
公开(公告)日:2018-11-21
申请号:EP17701006.3
申请日:2017-01-12
发明人: BALLOI, Eleanora , GOODWIN, Normann , MCGUINNESS, Brian , ROSSANT, Chris , SANDAL, Thomas , THOMPSON, Lorraine
CPC分类号: C07K16/3069 , A61K47/6811 , A61K47/6869 , A61K47/6889 , C07K2317/21 , C07K2317/35 , C07K2317/569 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/57434
摘要: The disclosure relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
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8.ANTI-IL-17RA IMMUNOGLOBULIN SINGLE HEAVY VARIABLE DOMAIN ANTIBODIES 审中-公开
标题翻译: 抗IL-17RA免疫球蛋白重链可变区抗体公开(公告)号:EP3247726A1
公开(公告)日:2017-11-29
申请号:EP16702191.4
申请日:2016-01-12
发明人: EDWARDS, Bryan , LASHMAR, Ulla , MCGUINNESS, Brian , ROMANOS, Mike , SANDAL, Thomas , YOUNG, Joyce
IPC分类号: C07K16/28 , A01K67/027 , C12N15/85
CPC分类号: C07K16/2866 , A01K67/0278 , A01K2217/07 , A01K2217/15 , A01K2267/03 , C07K2317/21 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
摘要: Binding molecules that bind specifically to IL-17RA. The binding molecules are useful in the treatment of disease,for example psoriasis.
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公开(公告)号:EP3247724A1
公开(公告)日:2017-11-29
申请号:EP16700518.0
申请日:2016-01-12
发明人: EDWARDS, Bryan , LASHMAR, Ulla , MCGUINNESS, Brian , ROMANOS, Mike , SANDAL, Thomas , TENG, Yumin
IPC分类号: C07K16/24
CPC分类号: C07K16/244 , A01K67/0278 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K2039/505 , A61P31/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07K2317/565 , C07K2317/569 , C07K2317/92 , G01N33/6869 , G01N2333/54
摘要: Binding molecules to IL-17A. The binding molecules are useful in the treatment of disorders, for example psoriasis.
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公开(公告)号:EP3245226A1
公开(公告)日:2017-11-22
申请号:EP16703351.3
申请日:2016-01-12
发明人: EDWARDS, Bryan , TENG, Yumin
CPC分类号: C07K16/005 , C07K16/00 , C07K16/244 , C07K16/2866 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/92 , C12N15/1037 , C12N15/1082
摘要: The invention relates to a method of designing an immunoglobulin library for optimisation of a biological property of a first lead immunoglobulin and libraries of optimised immunoglobulins produced by such methods.
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