公开(公告)号：EP1573325A1

公开(公告)日：2005-09-14

申请号：EP03780374.9

申请日：2003-12-11

申请人： Dynal Biotech ASA

发明人： FONNUM, Geir ,  MODAHL, Grete, Irene ,  STENE, Torkel ,  MOLTEBERG, Astrid, Evenrod ,  FINNE, Erling, Sigurd

IPC分类号： G01N33/543 ,  H01F1/00

CPC分类号： C09K11/06 ,  B82Y25/00 ,  B82Y40/00 ,  C08F220/18 ,  C09K11/025 ,  G01N33/5434 ,  H01F1/0018 ,  H01F1/01 ,  H01F1/26 ,  H01F41/00 ,  Y10T428/2991 ,  Y10T428/2998

摘要： A coated magnetic particle comprising an optionally porous magnetic polymer particle of a matrix polymer, said polymer particle having on a surface and/or in the pores thereof superparamagnetic crystals, said coated particle having a coat formed of a coating polymer, wherein said coated magnetic particle is essentially non-autofluorescent.

公开(公告)号：EP1468116A2

公开(公告)日：2004-10-20

申请号：EP03700880.2

申请日：2003-01-16

申请人： Dynal Biotech ASA

发明人： BOSNES, Marie

IPC分类号： C12Q1/68

CPC分类号： G01N33/6842 ,  G01N33/54306 ,  G01N33/68

摘要： The present invention comprises a method of isolating nucleic acid and protein from the same sample with solid supports, wherein nucleic acid and protein components contained in the sample become bound to distinct solid supports. The invention also allows for kits for isolating nucleic acid and protein from the same sample and for use of the method of isolating nucleic acid and protein for the analysis and/or comparison of mRNA and/or protein expression and/or their correlation to genomic information.

公开(公告)号：EP1268563A1

公开(公告)日：2003-01-02

申请号：EP01914034.2

申请日：2001-03-22

申请人： Dynal Biotech ASA

发明人： FONNUM, Geir ,  WENG, Ellen ,  AKSNES, Elin, Marie ,  NORDAL, Rolf ,  M RK, Preben, Cato ,  T GERSEN, Svein ,  COCKBAIN, Julian

IPC分类号： C08F2/18 ,  C08F257/00 ,  C08F112/08 ,  C08F285/00

CPC分类号： C08F8/32 ,  C08F212/14 ,  C08F257/02 ,  C08F285/00 ,  C08F291/00

摘要： The invention provides a process for the preparation of amine-functionalised vinyl polymer particles which process comprises suspension polymerizing aminostyrene together with at least one other vinylic monomer and optionally a crosslinking agent.

公开(公告)号：EP1729880A1

公开(公告)日：2006-12-13

申请号：EP05718043.2

申请日：2005-03-17

申请人： Dynal Biotech ASA

发明人： SONGE, Pal

IPC分类号： B01J20/26

CPC分类号： B01J20/26 ,  B01J20/265 ,  B01J20/28009 ,  B01J20/3242 ,  B01J20/3265 ,  B01J45/00

摘要： A process for covalently binding a tagged protein to a polymer particle comprising: contacting a tagged protein with a chelating agent-polymer particle conjugate wherein said tag comprises at least two histidine residues and at least two lysine residues and said chelating agent is tridentate, tetradentate or pentadentate and comprises at least two carboxyl groups and is coordinated by Co2+ ions, to form particle-chelating agent Co2+ complex: contacting said complex with a carbodiimide; and optionally removing the Co2+ ions.

公开(公告)号：EP0928342B1

公开(公告)日：2005-02-02

申请号：EP97942121.1

申请日：1997-09-26

申请人： Dynal Biotech ASA

发明人： LUNDEBERG, Joakim, Royal Institute of Technology ,  UHLEN, Mathias, Royal Institute of Technology

IPC分类号： C12Q1/68

CPC分类号： C12Q1/707 ,  C12Q1/6832 ,  C12Q2537/162 ,  C12Q2525/185

公开(公告)号：EP1240516A2

公开(公告)日：2002-09-18

申请号：EP00973029.2

申请日：2000-11-03

申请人： Dynal Biotech ASA

发明人： RANDEN, Ingrid

IPC分类号： G01N33/543

CPC分类号： G01N33/54306 ,  G01N33/54393 ,  G01N33/56972

摘要： The present invention provides a method of reversal of a linkage between an antibody and its target ligand comprising reacting said antibody-target ligand linkage with a B-cell superantigen, or a fragment thereof, which acts to reverse said linkage. The present invention further provides the use of this method in various isolation and purification methods, including cell detachment procedures, together with kits for carrying out such methods.

公开(公告)号：EP1693387A3

公开(公告)日：2007-04-11

申请号：EP06007361.6

申请日：2004-04-28

申请人： Dynal Biotech ASA

发明人： Fonnum, Geir ,  Hofsløkken, Nini Kjus ,  Aksnes, Elin ,  Kilaas, Lars ,  Stenstad, Per ,  Schmid, Ruth ,  Bjørgum, Jon Olav ,  Nilsen, Tom-Nils ,  Berge, Arvid Trygve

IPC分类号： G01N33/543 ,  C12Q1/68 ,  C08F220/32 ,  C08F8/30

CPC分类号： C08F8/30 ,  H01F1/0063

摘要： A process for the preparation of coated polymer particles containing superparamagnetic crystals, said process comprising reacting porous, surface-functionalized, superparamagnetic crystal-containing polymer particles of diameter 0.5 to 1.8 µm with at least one epoxide.

公开(公告)号：EP1268563B1

公开(公告)日：2006-11-22

申请号：EP01914034.2

申请日：2001-03-22

申请人： Dynal Biotech ASA

发明人： FONNUM, Geir ,  WENG, Ellen ,  AKSNES, Elin, Marie ,  NORDAL, Rolf ,  MORK, Preben, Cato ,  TOGERSEN, Svein

IPC分类号： C08F2/18 ,  C08F257/00 ,  C08F112/08 ,  C08F285/00

CPC分类号： C08F8/32 ,  C08F212/14 ,  C08F257/02 ,  C08F285/00 ,  C08F291/00

摘要： The invention provides a process for the preparation of amine-functionalised vinyl polymer particles which process comprises suspension polymerizing aminostyrene together with at least one other vinylic monomer and optionally a crosslinking agent.

公开(公告)号：EP1649284A1

公开(公告)日：2006-04-26

申请号：EP04729912.8

申请日：2004-04-28

申请人： Dynal Biotech ASA

发明人： FONNUM, Geir ,  HOFSLÖKKEN, Nini, Kjus ,  AKSNES, Elin ,  KILAAS, Lars ,  STENSTAD, Per ,  SCHMID, Ruth ,  BJÖRGUM, Jon, Olav ,  NILSEN, Tom-Nils ,  BERGE, Arvid, Trygve

IPC分类号： G01N33/543 ,  C12Q1/68 ,  C08F220/32

CPC分类号： H01F1/0045 ,  B82Y25/00 ,  C08F8/30 ,  G01N33/5434 ,  Y10T428/29 ,  Y10T428/2991 ,  Y10T428/2998 ,  Y10T428/31511 ,  Y10T428/31551

摘要： A process for the preparation of coated polymer particles containing superparamagnetic crystals, said process comprising reacting porous, surface functionalized, superparamagnetic crystal-containing polymer particles of diameter 0.5 to 1.8 µm with at least one polyisocyanate and at least one diol or at least one epoxide.

公开(公告)号：EP1638662A2

公开(公告)日：2006-03-29

申请号：EP04743113.5

申请日：2004-06-28

申请人： Dynal Biotech ASA

发明人： SONGE, Pal ,  FONNUM, Geir ,  KJUS, Nini Hofslokken ,  SANDBERG, Marcel Synthetica AS ,  NORDSTRAND, Solveig Synthetica AS ,  AUKRUST, Inger, Reidun Synthetica AS

IPC分类号： B01D15/08 ,  B01J20/32 ,  C07K1/22 ,  G01N30/02 ,  C08F8/32

CPC分类号： C07K1/22 ,  B01D15/3828 ,  B01J20/28009 ,  B01J20/3242 ,  B01J20/3251 ,  B01J20/3265 ,  B01J45/00 ,  C08F8/00 ,  C08F8/42 ,  H01F1/42

摘要： A conjugate comprising a magnetic polymer particle bound to a carboxymethylated aspartate chelating ligand, optionally chelating a metal ion.