公开(公告)号：EP0871620A4

公开(公告)日：1999-10-27

申请号：EP96935810

申请日：1996-09-11

申请人： ENZYMED INC

发明人： DORDICK JONATHAN S ,  CLARK DOUGLAS S ,  MICHELS PETER C ,  KHMELNITSKY YURI L

IPC分类号： C07D305/14 ,  C07D493/04 ,  C07H13/06 ,  C07H13/08 ,  C07H13/10 ,  C07H15/18 ,  C07H15/26 ,  C07H17/04 ,  C07H17/08 ,  C07H19/16 ,  C07D305/00 ,  C07D311/02

CPC分类号： C07D493/04 ,  C07D305/14 ,  C07H13/06 ,  C07H13/08 ,  C07H13/10 ,  C07H15/18 ,  C07H15/26 ,  C07H17/04 ,  C07H17/08 ,  C07H19/16

摘要： The invention is in the field of biologically active compounds such as taxol-2'-adipate derivatives, derivatives of bergenin and erythromycin derivatives. Taxol-2'-adipate derivatives have anti-cancer activity analogous to taxol. Bergenin derivatives have angiotensin converting enzyme inhibiting activity, and are therefore useful in the treatment of hypertension. Erythromycin derivatives are useful as antibiotics.

公开(公告)号：EP0871620A1

公开(公告)日：1998-10-21

申请号：EP96935810.0

申请日：1996-09-11

申请人： ENZYMED, Inc.

发明人： Dordick, Jonathan S. ,  Clark, Douglas S. ,  Michels, Peter C. ,  Khmelnitsky, Yuri L.

IPC分类号： C07D305 ,  C07D493 ,  C07H13 ,  C07H15 ,  C07H17 ,  C07H19

CPC分类号： C07D493/04 ,  C07D305/14 ,  C07H13/06 ,  C07H13/08 ,  C07H13/10 ,  C07H15/18 ,  C07H15/26 ,  C07H17/04 ,  C07H17/08 ,  C07H19/16

摘要： The invention is in the field of biologically active compounds such as taxol-2'-adipate derivatives, derivatives of bergenin and erythromycin derivatives. Taxol-2'-adipate derivatives have anti-cancer activity analogous to taxol. Bergenin derivatives have angiotensin converting enzyme inhibiting activity, and are therefore useful in the treatment of hypertension. Erythromycin derivatives are useful as antibiotics.

公开(公告)号：EP0713533A1

公开(公告)日：1996-05-29

申请号：EP94925870.0

申请日：1994-08-12

申请人： ENZYMED, Inc.

发明人： FOX, J. Wesley ,  DORDICK, Jonathan S. ,  CLARK, Douglas S.

IPC分类号： G01N33 ,  B01J19 ,  C07K1 ,  C12P1 ,  G01N35

CPC分类号： C07K1/047 ,  B01J19/0046 ,  B01J2219/00691 ,  G01N33/94 ,  G01N35/0099

摘要： This invention encompasses methods for producing a library of modified starting compounds by use of biocatalytic reactions on a starting compound and identifying the modified starting compound with the optimum desired activity. The invention encompasses starting compounds and modified compounds that are free in solution. The method is useful in producing modified pharmaceutical compounds with desired specific activity.