公开(公告)号：EP1784754A2

公开(公告)日：2007-05-16

申请号：EP05785616.3

申请日：2005-08-12

申请人： HARVARD UNIVERSITY ,  Meller, Amit ,  Mathe, Jerome ,  Eid, John S.

发明人： MELLER, Amit ,  MATHE, Jerome ,  EID, John S.

IPC分类号： G06F19/00

CPC分类号： C12Q1/6827 ,  C12Q1/6869 ,  G01N33/48721 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333 ,  C12Q2565/631 ,  C12Q2535/131 ,  C12Q2525/301

摘要： Described herein are methods for analyzing polymer molecules. These methods are employed for the high throughput readout of DNA and RNA molecules with single molecule sensitivity. The method of the present invention comprises (1) the electrically controlled unzipping of DNA (or RNA) double strands, and (2) the readout of the molecule's identity (or code) using one or more molecule signal detection.